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      주제어 : Anti-vascular Endothelial Growth Factor Drug (검색결과 2 건)
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      • KCI등재SCOPUS

        류마티스 활막세포에서 비스테로이드성 항염제에 의한 Vascular Endothelial Growth Factor 생성의 억제

        김용주 ( Yong Ju Kim ),박종서 ( Jong Seo Park ),최진정 ( Jin Jung Choi ),민소연 ( So Youn Min ),조미라 ( Mi La Cho ),김완욱 ( Wan Uk Kim ),박성환 ( Sung Hwan Park ),조철수 ( Chul Soo Cho ),김호연 ( Ho Youn Kim ) 대한류마티스학회 2001 대한류마티스학회지 Vol.8 No.4

        Objective: Vascular endothelial growth factor (VEGF), a potent angiogenic, permeability-enhancing cytokine plays an important role in chronic inflammatory process of rheumatoid arthritis (RA). Nonsteroidal anti-inflammatory drugs (NSAIDs) are the most widely used drugs for the treatment of RA. However, the effect of NSAIDs on angiogenesis in rheumatoid synovium is unclear. In this study, we investigated the effects of NSAIDs such as indomethacin (IDC) on TGF-β-induced VEGF production in rheumatoid synoviocytes. Methods: Fibroblast-like synoviocytes (FLS) from RA were stimulated with TGF-β (10 ng/ml) for 24hr in the presence of the various concentrations of IDC. The levels of VEGF were measured in culture supernatant by ELISA. In addition, COX-2 and VEGF mRNA expression of cultured FLS were evaluated by RT-PCR. Results: VEGF production from FLS was significantly increased in the presence of TGF-β. IDC exerted a dose-dependent inhibitory effect on the production of VEGF induced by TGF-β. RT-PCR analysis showed that IDC also inhibited TGF-β-induced COX-2 and VEGF mRNA expression in cultured FLS by a dose-dependent manner. Conclusion: Our results demonstrate that NSAIDs inhibit VEGF production and the expression of its mRNA and COX-2 mRNA in synovial cells of RA patients. These findings suggest that NSAIDs may suppress progression and perpetuation of rheumatoid synovitis by anti-angiogenic activity.

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        Real-World Treatment Intensity and Patterns in Patients With Myopic Choroidal Neovascularization: Common Data Model in Ophthalmology

        Bui Manh-Hung,Lee Da Yun,Park Sang Jun,Park Kyu Hyung 대한의학회 2023 Journal of Korean medical science Vol.38 No.23

        Background: A paucity of data addressing real-world treatment of myopic choroidal neovascularization (mCNV) in the era of anti-vascular endothelial growth factor (VEGF) drugs led us to investigate real-world treatment intensity and treatment patterns in patients with mCNV. Methods: This is a retrospective, observational study using the Observational Medical Outcomes Partnership-Common Data Model database of treatment-naïve patients with mCNV over the 18-year study period (2003–2020). Outcomes were treatment intensity (time trends of total/average number of prescriptions, mean number of prescriptions in the first year and the second year after initiating treatment, proportion of patients with no treatment in the second year) and treatment patterns (subsequent patterns of treatment according to the initial treatment). Results: Our final cohort included 94 patients with at-least 1-year observation period. Overall, 96.8% of patients received anti-VEGF drugs as first-line treatment, with most of injections from bevacizumab. The number of anti-VEGF injections in each calendar year showed an increasing trend over time; however, there was a drop in the mean number of injections in the second year compared to the first year from 2.09 to 0.47. About 77% of patients did not receive any treatment in their second year of treatment regardless of drugs. Most of patients (86.2%) followed non-switching monotherapy only and bevacizumab was the most popular choice either in the first-line (68.1%) or in the second-line (53.8%) of treatment. Aflibercept was increasingly used as the first-line treatment for patients with mCNV. Conclusion: Anti-VEGF drugs have become the treatment of choice and second-line treatment for mCNV over the past decade. Anti-VEGF drugs are effective for the treatment of mCNV as the non-switching monotherapy is the main treatment regimen in most cases and the number of treatments decreases significantly in the second year of treatment.

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