양수 알파태아단백과 태아핵형과의 상관관계

고경심,오보훈 단국대학교 1998 論文集 Vol.33 No.-

Amniotic fluid alpha-fetoprotein measurement is widely used to detect not only open neural tube defects but also other congenital anomalies. Our aim is to anlayse the relationship of amniotic fluid alpha-fetoprotein and fetal karyotyping. We include 1536 midtrimester pregnant women undergoing amniocentesis to detect fetal chromosomal abnormality in the cytogenetic laboratory at Dr. Oh’s genetic clinic and at Dankook University Hospital from February 1996 to December 1997. The most common indication for amniocentesis was abnormal triple makers. Overall incidence of chromosomal aberration was 28.0:1000(43/1536). Among chromosomal aberration, these were 31 cases of numerical aberration, 11 cases of structural aberration and one case of mosaicism. Amniotic fluid alpha-fetoprotein declined by 15 weeks gestation and upper and lower cut-of values was estimated by the suggestion of U.K. Collaborative Study91979). Amniotic fluid alpha-fetoprotein concentration of the group of chormosomal aberration was within normal limit according to the corresponding gestational age. We could no find any relationship between the amniotic fluid alpha-fetoprotein and the chromosomal aberration.

간문맥 혈전을 동반한 Alpha-Fetoprotein 분비 췌장 선암 1예

이오영,한동수,손주현,윤병철,고병회,함준수,박문향,이민호,이동후 大韓消化器病學會 1997 大韓消化器病學會誌 Vol.29 No.5

간세포암 진단에 있어서 Lens Culinaris Agglutinin-A에 반응하는 Alpha-fetoprotein 분획 ( L3 ) 측정의 임상적 의의

서동진(Dong Jin Suh),김연수(Yun Soo Kim),정영화(Young hwa Chung),이영상(Young Sang Lee) 대한소화기학회 1995 대한소화기학회지 Vol.27 No.6

N/A Background/Aims: Although alpha-fetoprotein(AFP) has been widely used as a tumor marker for hepatocellular carcinoma(HCC), it can be elevated in benign liver diseases as well and there is wide overlap between the two groups. Lens culinaris agglutinin-A(LCA-A) reactive AFP-L3 increases only in HCC and has been suggested to be a more specific diagnostic index for HCC than total AFP. We studied the diagnostic significance of AFP-L3 in patients with HCC and those with liver cirrhosis with high AFP concentrations()20ng/ml). Methods: Sera from 23 patients with HCC and 19 with liver cirrhosis were tested for AFP-L3 by lectin-affinity electrophoresis, coupled with antibody-affinity blotting by alpha-fetoprotein differentiation kit L(Wako Pure Chemical Industries, Osaka, Japan). Results: The positive rate of AFP L3 in HCC and LC was 96% and 42% respectively. AFP L3 fraction over 24.4% was found in 65.2% of HCC and 5% of LC. The sensitivity and the specificity of AFP L3 in HCC was 65.2% and 95% respectively. The percentage of AFP L3 in HCC was independent of the total serum level of AFP. Conclusion: It is suggested that measurement of AFP L3 is a more sensitive indicator than AFP for the diagnosis of HCC. AFP L3 is useful for the differential diagnosis of HCC and chronic benign liver diseases with high AFP and regular measurements of AFP-L3 would be helpful for the early detection of HCC in cirrhotic patients. (Korean J Gastroenterol 1995;27:672 678)

Alpha-fetoprotein 생산성 담낭암종 -1 증례 보고-

오영하,강행지,이헝근,홍은경,김용일,이중달 대한병리학회 1996 Journal of Pathology and Translational Medicine Vol.30 No.5

Alpha-fetoprotein 상승을 동반한 위암의 음낭 내 전이: 증례 보고

조영준,정재준,유정식,김주희,김대중,안지현,조은석 대한영상의학회 2010 대한영상의학회지 Vol.63 No.5

An alpha-fetoprotein-producing gastric cancer is rare, making up only about 3% of all gastric cancers. Further, gastric cancer with metastasis to the scrotum via a transperitoneal route is extremely rare. We report a case of metastatic scrotal mass in a 68-year-old man who had undergone a subtotal gastrectomy and gastroduodenostomy due to signet ring cell type gastric cancer with a description focusing on the radiologic findings. Alpha-fetoprotein (AFP)을 생산하는 위암은 전체 위암의 3% 정도로 드물며, 또한 위암이 경복막 전이에 의해 음낭에 전이성 병변을 형성하는 경우는 매우 드물다. 저자들은 AFP의 상승을 동반한 인환세포형 조기위암에서 수술 후 음낭 내로 전이된 전이성 종양 1예를 68세 남자에서 경험하였기에 CT 및 초음파 검사 소견과 함께 보고하는 바이다.

한국 여성의 정상 단태 임신에 있어서 임신중기 양수 내 alpha-fetoprotein의 정상범위

김준형 ( Jun Hyung Kim ),변영지 ( Young Ji Byun ),박재선 ( Jai Sun Park ),박진영 ( Jin Young Park ),양정인 ( Jeong In Yang ),김행수 ( Haeng Soo Kim ),유희석 ( Hee Suk Ryu ) 대한산부인과학회 2007 Obstetrics & Gynecology Science Vol.50 No.12

Objective: To determine normal range of amniotic fluid alpha-fetoprotein (AFAFP) in midtrimester singleton Korean pregnant women whose pregnancy and neonatal outcomes were uneventful. Methods: AFAFP levels were measured in midtrimester pregnancy during amniocentesis from May 1995 to September 2006 at tertiary referral center. Normal ranges were obtained from 954 singleton pregnancies in which pregnancy and neonatal outcomes were normal. Results: Median values of AFAFP in midtrimester pregnancy were 15,800 ng/mL, 13,903.9 ng/mL, 11,408.7 ng/mL, 9,690.1 ng/mL, 6,923.4 ng/mL, 6,330.0 ng/mL, 5,295.3 ng/mL, 4,421.2 ng/mL, 3,162.5 ng/mL at 16 week, 17 week, 18 week, 19 week, 20 week, 21 week, 22 week, 23 week, and 24 week. Conclusion: The normal range of AFAFP level in each gestational week in Korean women could be a good reference for prenatal diagnosis of various disorders.

임신중기 원인불명 모체혈청 알파태아단백치 상승이 주산기 예후인자로서 가치

양윤석(YS Yang) 대한산부인과학회 1997 Obstetrics & Gynecology Science Vol.40 No.8

The aim of the study was to evaluate the significance of unexplained elevated mater- nal serum alpha-fetoprotein in singleton pregnancies as a prediction of fetal risk. The inclusion criteria for patents with unexplained MSAFP elevations were a MSAFP level 2.0 or greater multiples of the median ( MoM ) , a single gestation, a confirmed gestatio- nal age and no fetal malformation or death on ultrasonography. In this study , 991 woman who attended the antenatal clinic at Taejeon Eul Ji Hospital from March , 1996 to March , 1997 were reviewed and data from 79 women with elevated maternal serum alpha-fetoprotein levels were analysed. The 67 of 79 patients with elevated maternal serum alpha-fetoprotein levels had on unexplained elevated MSAFP level. 13 women could not follow up. 54 pregnant women with unexplained elevated MSAFP levels were classified as the index group of singleton pregn- ancy and were matched against a control group. 108 patients with MSAFP levels 0.5 to 2.0 MoM served as control group. The incidence of antepartum hemorrhage ( placental previa ) , preterm labor , intrauterine growth retardation ( IUGR ) , low birth weight and pregnancy induced hypertension ( PIH ) in two groups was analyzed and the results was subjected to Fisher`s Exact Test. None of the patients in the index group had chromosomal abnormalites or birth defect. IUGR occurred in 7 ( 12.96% ) of the index group babies but in only 3 ( 2.78% ) in the control group ( p<0.02 ). preterm labor occurred in 5 ( 9.26% ) in the index group compared with 2 ( 1.85% ) in the control group ( p<0.05 ). low birth weight occurred in 3 ( 5.5% ) of the index group babies and in 1 ( 0.9% ) in the control group ( p<0.1 ). This study suggests that patients with unexplained midtrimester elevations of MSAFP are increased risk for IUGR , preterm labor. But no significance differences were observed in the incidence of low birth weight , antepartum hemorrhage ( placental previa ) , PIH.

HBV : Serial Changes in Serum Alpha-Fetoprotein Levels before and after Entecavir Therapy in Nucleoside-Na?ve Patients with Chronic Hepatitis B

( Sung Wook Yang ),( Jung Wha Chung ),( Sang Soo Lee ),( Sukho Hong ),( Seong Min Chung ),( Eun Sun Jang ),( Jin Wook Kim ),( Sook Hyang Jeong ) 대한간학회 2013 춘·추계 학술대회 (KASL) Vol.2013 No.1

Background: Serum level of alpha-fetoprotein (AFP) can elevate in patients with chronic hepatitis B (CHB) without evidence of hepatocellular carcinoma. However, the response of AFP levels to oral nucleos(t)ide analog is not elucidated yet. In this study, we retrospectively assessed the prevalence of high serum AFP levels in CHB patients who were treated with entecavir (ETV), and patterns of AFP changes during the entecavir therapy. Methods: A total of 110 CHB patients who started ETV as an initial antiviral therapy were enrolled in this retrospective study. Pre-treatment clinical , biochemical and virologic parameters were evaluated in relation to the serial AFP levels. Results: The mean baseline AFP value was 41.2 ng/dL. Before ETV therapy (range: 1.3-840 ng/dL). Among the 110 patients, fourty-six (41.8%) showed high pre-treatment AFP values (>10 ng/dl). In the high AFP group, Aspartate transaminase (AST), Alkaline phosphatase (ALP), bilirubin, albumin and prothrombin time (PT) were significantly higher compared to normal AFP group (P=0.021, 0.005, 0.000, 0.001 and 0.004, respective). Only baseline albumin level was significant predictor of high AFP level in multivariate logistic regression analysis (P=0.043, HR=0.00). In high AFP group, The cumulative normalization rates of AFP levels were 26.1%, 73.9% and 91.3% at 18, 36 and 72 weeks, respectively. Serum DNA level was significantly correlated to the time to AFP normalization in a Kaplan-Meier analysis (P=0.039). Conclusions: AFP frequently elevates in CHB patients who undergoes oral nucleoside analog therapy, and baseline albumin level was significantly associated with high AFP level. Normalization of AFP is delayed and about 1/3 shows high AFP levels up to 3 years of ETV therapy. Baseline DNA level was associated with delayed AFP normalization after ETV therapy.

Decreased of Alpha-Fetoprotein Level Among Patients with Liver Cirrhosis that Related to HCV Treated with Combination Therapy with Ledipasvir and Sofosbuvir

( Batsukh Dashnyam ),( Bayarmaa Nyamaa ),( Nyam Biziya ),( Oyundelger Munkhtuvshin ) 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1

Aims: Hepatocellular carcinoma (HCC) is considered one of the most lethal cancers, with most of cases diagnosed at advanced stage. The prevalence of HCC is high in Mongolia with men 116.6 cases and women 74.8 cases per 100,000 person-years. The hepatitis C virus (HCV) infection is one of the major causes of chronic hepatitis and hepatocellular carcinoma (HCC) in Mongolia. Viral infection with HCV can cause fluctuations in AFP that makes it difficult to differentiate between underlying liver disease and the development of HCC. The lack of specificity has limited the role of serum alpha-fetoprotein (AFP) for hepatocellular carcinoma (HCC) screening among patients with cirrhosis related to hepatitis C virus (HCV) infection. Methods: Here we report 25 cases decreased of AFP level in patients with cirrhosis treated 24 weeks combination therapy with ledipasvir and sofosbuvir between 2017 to 2020 were referred to the Liver Unit, Dornod Medical center Mongolia. All patients had been tested for blood chemistries, liver function markers, such as alanine aminotransferase (ALT), total bilirubin, prothrombin, international normalized ratio (INR), creatinine, AFP and HCV-RNA. Results: Of all patients, fifteen were man and ten were woman. The average age of the testimonies was 53 (between 40 and 67 years). All patients had HCV genotype 1b and had HCV-RNA positive. The combination of the therapy with ledipasvir and sofosbuvir had significantly decreased level of HCV-RNA from 2172560 to not detected (P<0.05), ALT from 119.4 to 28.4 (P<0.05), AFP from 42.8 to 12.2 (P<0.05). Conclusions: In conclusion, the combination of the therapy with ledipasvir and sofosbuvir is decreased AFP level and improved liver function tests in HCV related liver Cirrhosis of those patients.

HCC : PE-045 ; Initial alpha-fetoprotein response as a predictor of intrahepatic recurrence of hepatitis B-related hepatocellular carcinoma after radiofrequency ablation therapy

( Jee Hye Kwon ),( Won Kim ),( Donghee Kim ),( Yong Jin Jung ) 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.1

Background: Initial alpha-fetoprotein (AFP) response might affect clinical outcomes after systemic chemotherapy for advanced HCC. In this study, we aimed to find the correlation between initial AFP response and intrahepatic recurrence of hepatitis B-related HCC after RFA. Methods: A total of 615 consecutive patients underwent RFA for HBV-related HCC at Seoul National University Hospital from January 2005 to June 2010. We retrospectively collected and reviewed clinical data from electronic medical records. Patients with no available AFP data at baseline or initial serum AFP <20 ng/mL were excluded from analysis. AFP response was defined as >50% decline from baseline 1 month after RFA. Results: A total of 255 patients undergoing RFA for HBVrelated HCC were included in this study. Mean age of study population was 56.8±8.7 years and 177 (70%) were males. Two hundred and forty-six had Child-Pugh class A and 9 had class B. One hundred and thirty-two had no previous history of HCC treatment, 29 received resection, 3 for RFA, 27 for percutaneous ethanol injection, and 64 for transarterial chemoembolization. The type of recurrence was as follows; local recurrence (33): remote recurrence (112): both local and remote recurrence (13). In multivariate analysis, AFP >50% decline (HR 0.507; 95% CI 0.348-0.738; p<0.001), previous history of TACE (HR 2.149; 95% CI 1.439-3.210; p<0.001), and male gender (HR 1.715; 95% CI 1.090-2.699; p=0.020) were independent predictors of remote recurrence. Conclusions: Biologic response such as initial serum AFP decline significantly predicted intrahepatic remote recurrence after RFA for locoregional HCC. Moreover, HCC patients with initial AFP decline ≤50% after RFA should be considered for further treatment modalities.