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      • KCI등재

        A Rare Case of Intramural Müllerian Adenosarcoma Arising from Adenomyosis of the Uterus

        이선재,박지영 대한병리학회 2017 Journal of Pathology and Translational Medicine Vol.51 No.4

        Müllerian adenosarcomas usually arise as polypoid masses in the endometrium of post-menopausal women. Occasionally, these tumors arise in the cervix, vagina, broad and round ligaments, ovaries and rarely in extragenital sites; these cases are generally associated with endometriosis. We experienced a rare case of extraendometrial, intramural adenosarcoma arising in a patient with adenomyosis. A 40-year-old woman presented with sudden-onset suprapubic pain. The imaging findings suggested leiomyoma with cystic degeneration in the uterine fundus. An ill-defined ovoid tumor with hemorrhagic degeneration, measuring 7.5 cm in diameter, was detected. The microscopic findings showed glandular cells without atypia and a sarcomatous component with pleomorphism and high mitotic rates. There was no evidence of endometrial origin. To recognize that adenosarcoma can, although rarely, arise from adenomyosis is important to avoid overstaging and inappropriate treatment.

      • KCI등재후보

        A Case of Solitary Brain Metastasis from Uterine Mullerian Adenosarcoma with Sarcomatous Overgrowth

        ( Suk Bo Hong ),( Min Jung Kim ),( Ji Yeon Kwon ),( Seok Jin Choi ),( Eun Young Kim ),( Joohan Lim ) 대한뇌종양학회·대한신경종양학회·대한소아뇌종양학회 2016 Brain Tumor Research and Treatment Vol.4 No.2

        Uterine adenosarcoma (AS) are rare tumors and have more favorable outcomes than the aggressive uterine carcinosarcomas. Uterine adenosarcoma with sarcomatous overgrowth (ASSO) is a variant form of AS and exhibits aggressive growth of tumor and the prognosis is relatively poor compared with typical AS. Usually patterns of metastasis have been known to behave like endometrial carcinoma and spread through the lymphatics. Brain metastasis from uterine AS is extremely rare. Herein, we report a case of successfully surgically removed solitary brain metastasis without any extracranial recurrence from uterine ASSO after 4 years of primary treatment.

      • KCI등재

        MR Findings of Extrauterine Mu ?llerian Adenosarcoma Associated with Deep Pelvic Endometriosis

        오대근,김찬교,박병관,김지영 대한영상의학회 2008 대한영상의학회지 Vol.58 No.2

        Extrauterine m¨ullerian adenosarcoma is a very rare tumor and it is characterized by a benign glandular component and a low-grade sarcomatous stromal component. These tumors have been reported to arise from ovarian or extraovarian endometriosis. However, there are scant reports on the MR findings of extrauterine mu ¨llerian adenosarcoma arising from deep pelvic endometriosis. We describe here a case of a large infiltrating extrauterine m¨ullerian adenosarcoma arising from recurrent deep pelvic endometriosis and we discuss its MR findings.

      • KCI등재후보

        A Case of Solitary Brain Metastasis from Uterine Mullerian Adenosarcoma with Sarcomatous Overgrowth

        홍석보,김민정,권지연,최석진,김은영,임주한 대한뇌종양학회 2016 Brain Tumor Research and Treatment Vol. No.

        Uterine adenosarcoma (AS) are rare tumors and have more favorable outcomes than the aggressive uterine carcinosarcomas. Uterine adenosarcoma with sarcomatous overgrowth (ASSO) is a variant form of AS and exhibits aggressive growth of tumor and the prognosis is relatively poor compared with typical AS. Usually patterns of metastasis have been known to behave like endometrial carcinoma and spread through the lymphatics. Brain metastasis from uterine AS is extremely rare. Herein, we report a case of successfully surgically removed solitary brain metastasis without any extracranial recurrence from uterine ASSO after 4 years of primary treatment.

      • KCI등재

        Safety of ovarian preservation in premenopausal women with stage I uterine sarcoma

        Dimitrios Nasioudis,Eloise Chapman-Davis,Melissa Frey,Kevin Holcomb 대한부인종양학회 2017 Journal of Gynecologic Oncology Vol.28 No.4

        Objective: To evaluate the oncologic safety of ovarian preservation (OP) in premenopausalwomen diagnosed with the International Federation of Gynecology and Obstetrics (FIGO)stage I uterine sarcoma. Methods: The National Cancer Institute's Surveillance, Epidemiology, and End Resultsdatabase was accessed and a cohort of women aged ≤50 diagnosed between 1988–2013 witha sarcoma limited to the uterus was drawn. Based on site-specific surgery codes, womenwho underwent hysterectomy with or without oophorectomy and did not receive radiationtherapy were selected for further analysis. Overall (OS) and cancer-specific (CSS) survivalwere determined following generation of Kaplan-Meier curves; comparisons were made withthe log-rank test. A Cox-proportional hazard model was constructed to control for possibleconfounders. Results: A total of 1,482 women were included in the analysis; 800 (54.0%) were diagnosedwith leiomyosarcoma (LMS), 520 (35.1%) with low-grade endometrial stromal sarcoma(LG-ESS), and 162 (10.9%) with adenosarcoma (AS). The OP group included 418 women(28.2%). Differences in the rate of OP were noted based on histology (p=0.014), year ofdiagnosis (p=0.001), patient age (p<0.001) and race (p=0.012). There was no difference in OS(p=0.220) or CSS (p=0.210) between women who had OP and those who did not. Multivariateanalysis confirmed that OP was not associated with a worse mortality. Conclusion: In this population-based cohort of women with sarcoma limited to the uterus,OP was not associated with worse oncologic outcomes. OP could be considered for womenwith LMS, sparing them from the morbidity associated with iatrogenic menopause. Noconclusions could be made for those with LG-ESS or AS.

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