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- 검색키워드
- 주제어 : 4-Dichlorobutane (검색결과 5 건)
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1,4-Dichlorobutane 생식능 및 차세대영향시험
정용현 ( Yong Hyun Chung ),김종규 ( Jong Kyu Kim ),유욱준 ( Wook Joon Yu ) 한국산업위생학회 2013 한국산업보건학회지 Vol.23 No.3
Objectives: The present study was conducted in order to investigate the reproductive toxicity in rats exposed to 1,4-dichlorobutane. Methods: The test chemical was administered orally at 0, 8.3, 50 and 300 mg/kg/day. Males were administered daily for 10 weeks prior to the mating period. Females were administered from between two weeks before mating to the 21stday of lactation. Results: In both sexes, a decrease in body weight and an increase in the weights of the liver and kidneys were observed. In males, discoloration of the liver, hepatocyte hypertrophy and mineralization in the kidneys were observed. In females, animal deaths, dystocia and pup deaths due to maternal dysfunction were observed. In F1 animals of both sexes, a decrease in body weight was observed at 300 mg/kg/day. An increase in the weights of the liver in both sexes, mineralization in the kidneys of males, animal deaths, hepatocyte hypertrophy and pup deaths due to maternal dysfunction were observed at 50 mg/kg/day. Mineralization in the kidneys of males was observed at 8.3 mg/kg/day. Therefore, the no-observed-adverse-effect ROSs of 1,4- dichlorobutane were considered to be under 8.3 mg/kg/day for males, 8.3 mg/kg/day for females, more than 300 mg/kg/day for fertility in both sexes, 8.3 mg/kg/day for maternal functions and 50 mg/kg/day for F1 offspring. The absolute toxic dose was believed to be 8.3 mg/kg/day for males, 50 mg/kg/day for females, 50 mg/kg/day for maternal functions and 300 mg/kg/day for F1 offspring. However NOAEL for fertility could not be determined since there were no treatment-related changes. Conclusions: Under the present experimental conditions, 1,4-dichlorobutane is a Category 1B Reproductive Toxicant (presumed human reproductive or developmental toxicant).
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4-Week repeated oral dose toxicity study of 1,4-dichlorobutane in rats
Wook-Joon Yu,In-Chul Lee,Jinsoo Lee,Sang-Min Lee,Sung-Hwan Kim,Hyung-Seon Baek,Changjong Moon,Sung-Ho Kim,Yong-Hyun Chung,Jong-Choon Kim 한국실험동물학회 2013 Laboratory Animal Research Vol.29 No.1
The present study investigated the potential subacute toxicity of 1,4-dichlorobutane by a 4-week repeated oral dose in Sprague-Dawley rats. The test article was administered once daily by gavage to male rats at dose levels of 0, 100, 300, and 1,000 mg/kg/day for 4 weeks. All rats were sacrificed at the end of the treatment period. During the test period, clinical signs, mortality, body weight, hematology, serum biochemistry, gross findings, and organ weight were examined. At 1,000 mg/kg/day, an increase in the clinical signs and weights of the liver and kidneys was observed in the male rats. Serum biochemical investigations revealed an increase in alanine aminotransferase, alkaline phosphatase, total cholesterol, total bilirubin, phospholipids, blood urea nitrogen, and gamma glutamyl transferase levels. There were no treatment-related adverse effects in the low and middle-dose groups. In the present experimental conditions, the target organs were determined to be liver and kidney. The no-observed-adverse-effect level was considered to be 300 mg/kg/day in rats.
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In Vivo Micronucleus Test of Methylcyclopentane and 1,4-Dichlorobutane
( Kyung Taek Rim ),( Soo Jin Kim ),( Jong Kyu Kim ),( Yong Hyun Chung ),( Sang Yong Park ),( Jeong Sun Yang ) 한국환경분석학회 2011 환경분석과 독성보건 Vol.14 No.2
We investigated the genotoxicity of two chemicals, methylcyclopentane and 1,4-dichlorobutane with in vivo micronucleus test. Although these two chemicals have already been tested many times, a micronucleus test has not been conducted and the usage of these chemicals has been recently increased. 7 week male ICR mice were tested at dosages of 500, 1,000, and 2,000 mg/kg for methylcyclopentane and 500, 1,000, and 2,000 mg/kg for 1,4-dichlorobutane, respectively. After 24 hours of oral administration with the two chemicals, the mice were sacrificed and their bone marrow cells were prepared for smearing slides. As a result of counting the micronucleated polychromatic erythrocyte (MNPCE) of 2,000 polychromatic erythrocytes (PCE), all treated groups expressed no statistically significant increase of MNPCE compared to the negative control group. There were no clinical signs related with the oral exposure of these two chemicals. It was concluded that the two chemicals did not induce micronucleus in the bone marrow cells of ICR mice, and there was no direct proportion with dosage. These results indicate that the two chemicals have no mutagenic potential under each study condition.
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1,4-Dichlorobutane의 랫드 2주 반복경구투여독성시험
김종규 ( Jong Kyu Kim ),이인철 ( In Chul Lee ),김성환 ( Sung Hwan Kim ),백형선 ( Hyung Seon Baek ),배진숙 ( Jin Sook Bae ),송시환 ( Si Whan Song ),김종춘 ( Jong Choon Kim ),정용현 ( Yong Hyun Chung ) 한국산업위생학회 2013 한국산업보건학회지 Vol.23 No.1
OObbjjeeccttiivveess:: The present study investigated the potential subacute toxicity of 1,4-dichlorobutane (1,4-DCB) by a 2-week repeated oral dose in male Sprague-Dawley rats. MMaatteerriiaallss aanndd MMeetthhooddss:: The test chemical was administered once daily by gavage to male rats at dose levels of 0, 74, 222, 667, and 2000 mg/kg/day for 2 weeks. All rats were sacrificed at the end of treatment period. During the test period, clinical signs, mortality, body weights, food and water consumption, urinalysis, hematology, serum biochemistry, gross findings, and organ weights were examined. RReessuullttss:: At 2000 mg/kg/day, treatment-related clinical signs, as evidenced by hypothermia, decreased locomotor activity, piloerection, lying on side, and prone position were observed. All the rats were found dead on test day 2. At 667 mg/kg/day, polyuria, suppressed body weight gain, food consumption, and spleen and thymus weights, and increased adrenal gland and liver weights were observed.Hematological and serum biochemical investigations revealed increases in the alanine aminotransferase, alkaline phosphataseand total bilirubinand decreases in the serum Na+ level, white blood cell count and lymphocyte ratio. There were no treatment-related adverse effects in the 74 and 222 mg/kg/day groups. CCoonncclluussiioonnss:: In the present experimental conditions, target organs were determined to be spleen, thymus,and liver. The no-observed-adverse-effect level was considered to be 222 mg/kg/day in male rats.
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In Vivo Micronucleus Test of Methylcyclopentane and 1,4-Dichlorobutane
임경택,김수진,김종규,정용현,박상용,양정선 한국환경분석학회 2011 환경분석과 독성보건 Vol.14 No.2
We investigated the genotoxicity of two chemicals, methylcyclopentane and 1,4-dichlorobutane with in vivo micronucleus test. Although these two chemicals have already been tested many times, a micronucleus test has not been conducted and the usage of these chemicals has been recently increased. 7 week male ICR mice were tested at dosages of 500, 1,000, and 2,000 mg/kg for methylcyclopentane and 500, 1,000, and 2,000 mg/kg for 1,4-dichlorobutane, respectively. After 24 hours of oral administration with the two chemicals, the mice were sacrificed and their bone marrow cells were prepared for smearing slides. As a result of counting the micronucleated polychromatic erythrocyte (MNPCE) of 2,000 polychromatic erythrocytes (PCE), all treated groups expressed no statistically significant increase of MNPCE compared to the negative control group. There were no clinical signs related with the oral exposure of these two chemicals. It was concluded that the two chemicals did not induce micronucleus in the bone marrow cells of ICR mice, and there was no direct proportion with dosage. These results indicate that the two chemicals have no mutagenic potential under each study condition.
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