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무통분만을 위한 경막외 진통에서 Fentanyl의 용량에 따른 0.2% Ropivacaine의 작용발현시간과 작용지속시간
방은치,신지현,이현숙,강용인,조경숙,김수연 대한마취통증의학회 2010 Anesthesia and pain medicine Vol.5 No.3
Background:The purpose of this study was to identify the effect of fentanyl dose on the onset and duration of 0.2% ropivacaine. Methods:Sixty-one nulliparous women with singleton vertex pregnancy who requested epidural labor analgesia were enrolled.Patients were administered randomly 0, 50, 100μg of fentanyl with 10 ml of 0.2% ropivacaine (Group F0, F50 and F100, respectively).VAS pain scores were recorded 0, 5, 10, 15 min after epidural injection, after which they were recorded every 15 min.The onset and duration of analgesia were measured.Side effects such as, pruritus, motor blockade, and hypotension were recorded.Satisfaction scores, type of delivery, and neonatal outcomes were recorded. Results:The onset of analgesia was at 8.5 ± 3.4 min in Group F100, compared with 13.7 ± 7.2 min in Group F0 and 13.6 ± 5.3 min in Group F50 (P = 0.009).The duration of analgesia was 122.6 ± 20 min in Group F100, compared with 72.3 ± 21.2 min in Group F0 and 97.8 ± 22.4 min in Group F50 (P = 0.000).There were significant differences in VAS pain scores and satisfaction scores among the three groups. There were no differences in the incidences of maternal side effects and operative delivery or neonatal outcomes. Conclusion:Fentanyl 100μg was the most appropriate dose when combined with 0.2% ropivacaine due to the rapid onset and long duration of epidural labor analgesia.
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