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인후두 역류증에 대한 초치료로서 양성자 펌프 억제제4주 단기 치료의 효과
정만기,민진영,오재원,정한신,백정환,손영익 대한이비인후과학회 2005 대한이비인후과학회지 두경부외과학 Vol.48 No.6
Background and Objectives:Proton pump inhibitors (PPIs) can improve the symptoms of laryngopharyngeal reflux (LPR)if used for more than 8 weeks, but little information is available on the effects of short-term PPI therapy as an initial treatmentfor LPR. We aimed to evaluate the efficacy of 4-week short-term PPI medication as an initial treatment for LPR and to identifyspecific symptoms which can predict the outcome of treatment. Subjects and Method:Among the patients complaining ofmore than 3 typical LPR symptoms for over 3 months, 62 patients with LPR symptom scores over 8 points were enrolled for thestudy. The patients were randomly subjected either to the 4 weeks of prokinetics (n=31) or PPI (n=31) medication. Changesin subjective symptoms and objective findings were assessed at first visit and 4 weeks after the medication. Results:Treatmentwith prokinetics or PPI resulted in more than 50% reduction of LPR symptom scores in 9.6% or 29% of the patientsrespectively and 25-50% reduction in 54.8% or 70.9% of them. Objective reflux findings didn’t get improved in either group.Analyses of the obtained reflux symptom scores failed to predict the treatment outcome of PPI medication. Conclusion:ShorttermPPI therapy is highly effective for the reduction of LPR symptoms in selected patients, which may validate the use of PPIas an initial treatment regimen for the patients with LPR. However, further studies are required to assess the long-term effects of4-week PPI therapy as an initial treatment regimen.
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