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培養 脊髓 運動神經細胞에서 메틸수은에 對한 Vitamin E의 影響에 關한 硏究
李建穆,趙廷九,金仁淑,朴承澤,洪起年,螢根寧,李廷憲,徐銀俄,石勝瀚,趙光皓,崔珉圭,李昊燮,田炳薰,禹元洪,李康昌 대한동의병리학회 2000 동의생리병리학회지 Vol.14 No.1
메틸수은의 신경독성을 조사하기 의하여 생쥐의 배양 척수 운동신경세포를 여러 농도의 메틸수은에서 24시간 동안 배양한 후 MTT 분석법과 신경세사효소면역분석법으로 세독성을 분석하였으며, 또한 메틸수은에 신경세포에 대한 항산화제인 vitamin E의 방어효과를 조사하였다. 메틸수은은 처리한 농도와 시간에 비례하여 척수 운동세포의 생존율을 현저히 감소시켰다. 항산화제의 방어효과에 있어서는 vitamin E가 메틸수은에 의해서 유도된 신경독성을 방어하였다. 위의 결과로부터 메틸수은은 생쥐의 배양 척수 운동신경세포에 신경독성을 나타냈으며 vitamin E와 같은 선택적인 항산화제가 메틸수은의 독성을 방어하는데 매우 효과적이다. In order to evaluate the neurotoxic effect of methylmercuric chloride(MMC) on cultured mouse spinal motor neurons. cytotoxic effect was measured by MTT assay and neurofilament enzymeimmunoassay(EIA) after cultured mouse spinal motor neurons were incubated with various concentrations of MMC for 24 hours. The neuroprotective effect of antioxidant, vitamin E against MMC-mediated nurotoxicity was also examined in these cultures. MMC decreased cell viability of cultured mouse spinal motor neurons remarkably in a dose-and time-dependent manners. In protective effect of antioxidant, vitamin E was remarkably effective in blocking the neurotoxicity induced by MMC in MTT assay and neurofilament enzymeimmunoassay. From these results, it is regarded that MMC induce neurotoxicity, and the selective antioxidant such as vitamin E is very effective in blocking MMC-mediated neurotoxicity on cultured mouse spinal motor neurons
김재현 동덕여자대학교 2003 생활과학연구 Vol.8 No.-
Mercury contamination in the ecosystem is one of the most important issue in the environmental and health problems. Currently, no human consumption of sport fish is recommended due to high Hg levels in fish tissues in some area of USA. The alkylmercury(methyl-and ethylmercury) has been regulated under the several environmental laws in Korea but not clear in fish consumption even if all Hg contained in edible fish is MeHg. A understanding of the environmental processes and monitoring, controlling the environmental fate of MeHg, is requisite to making responsible ecosystem management decisions, and research strategies. Information necessary to learn aquatic fate includes, the consistent monitoring and rates of MeHg cycle, terrestrial and aquatic factors(such as water chemistry) that either exacerbate or mitigate MeHg production, and food-web bioaccumulation pathways.
흰쥐의 감각신경절세포에 대한 Methylmercuric chloride의 독성효과
鄭榮吉,白承和,韓斗錫,柳道坤,朴承澤 한국전통의학연구소 1998 한국전통의학지 Vol.8 No.1
흰쥐의 배양 척수감각신경절세포에 대한 methylmercuric chloride(MMC)의 세포독성을 조사하기 위하여 여러 농도의 MMC가 포함된 배앙액에서 24시간 동안 배양한 후 MTI assay법에 의하여 세포의 생존율을 조사하였다. MMC는 농도에 비례하여 세포의 생존율을 감소시켰다. 또한 여러 농도의 MMC가 포함된 배앙액에서 흰쥐의 척수 감각신경절(dorsal root ganglion, DRG) 세포를 24시간 동안 처리한 결과 MTI_(50) 값이 25μM MMC에서 나타났다. MMC는 Borenfreund등(1988)의 독성판정기준에 의하여 흰쥐의 배앙 DRG 세포에 고독성인 것으로 나타났다. 이상의 결과는 MMC가 흰쥐의 배양 척수감각신경절세포에 강한 신경독성 효과가 있음을 제시하였으며 또한 배양신경세포는 약제의 효과를 검색하는데 효과적이었다. To examine the cytotoxic effect of methyl mercuric chloride(MMC) on the cultured rat spinal dorsal root ganglion(ORG) neurons, cell viability was measured by MTT assay after rat spinal ORG neurons were incubated with media containing various concentrations of MMC for 24 hours The results were as follows ; 1. MMC decresed cell viability of rat spinal ORG neurons in a dose-dependent manner. 2. MIT_(950) value was a 25uM MMC after spinal ORG neurons were cultured for 24 hours at various concentrations of MMC. 3. MMC was heighly toxic on the cultured ORG neurons by the toxic criteria of Borenfreund et al.(1988). From above the results, it is suggested that methylmercury involves in neurotoxicity by the decrease of cell viability in cultured rat spinal DRG neurons, and cultured neurons are effective in screening the putative agents.