뇌 회백질 기저핵 부위의 흡연유무에 따른 확산텐서 비등방도 측정값 차이분석

곽종혁 ( Jong Hyeok Kwak ),정재범 ( Jae Beom Jeong ),손봉경 ( Bong Kyeong Son ),성순기 ( Soon Ki Sung ),김성진 ( Seong Jin Kim ),강동원 ( Dong Won Kang ),박찬혁 ( Chan Hyeok Park ),임현화 ( Hyeon Wha Im ),이유희 ( Yu Hui Lee ) 한국방사선학회 2018 한국방사선학회 논문지 Vol.12 No.2

흡연 유무의 남성을 대상으로 뇌 회백질의 손상 유무를 파악 할 수 있는 확산텐서영상을 검사하여 영상을 획득 한 후 Tract-Based Spatial Statics(TBSS)방법으로 뇌 회백질 부위의 기저핵 신경섬유로의 비등방도 FA(fractional anisotropy)값을 측정 분석한 결과 모든 영역에서 흡연자가 비흡연자보다 비등방성 측정값이 낮게 관찰되었으며 FA값은 통계적으로 유의하였다. 본 연구의 측정한 FA결과 값으로 추측하자면 즉, 흡연이 뇌 회백질 기저핵의 모든 해부학적 미세 구조성 변화에 크게 영향을 미치며 신경 섬유로를 손상시키고 이와 관련된 기능적 이상에 영향을 준다고 할 수 있다. The fractional anisotropy value of the basal ganglia fibers in the brain gray matter region was analyzed by Tract-Based Spatial Statics(TBSS) method after acquiring the diffusion tensor image to identify the presence or absence of brain white matter damage to smoking in male. As a result of measurement analysis, the fractional anisotropy measurement value was lower in smokers than non-smokers in all areas, and the FA value was statistically significant. smoking significantly affects all the anatomic micro structural changes in the brain gray matter and damages the nerve fiber tract. As a result, it can affects functional abnormalities related to the minute changes of the brain due to smoking.

Analysis of Differences in Fractional Anisotropy of Diffusion Tensor Images of Basal Ganglia in the Brain Gray Matter according to Smoking

Jong Hyeok Kwak(곽종혁),Jae Beom Jeong(정재범),Bong Kyeong Son(손봉경),Soon Ki Sung(성순기),Seong Jin Kim(김성진),Dong Won Kang(강동원),Chan Hyeok Park(박찬혁),Hyeon Wha Im(임현화),Yu Hui Lee(이유희),Bong Sang Lee(이상봉),Dong hye 한국방사선학회 2018 한국방사선학회 논문지 Vol.12 No.2

The fractional anisotropy value of the basal ganglia fibers in the brain gray matter region was analyzed by Tract-Based Spatial Statics(TBSS) method after acquiring the diffusion tensor image to identify the presence or absence of brain white matter damage to smoking in male. As a result of measurement analysis, the fractional anisotropy measurement value was lower in smokers than non–smokers in all areas, and the FA value was statistically significant. smoking significantly affects all the anatomic micro structural changes in the brain gray matter and damages the nerve fiber tract. As a result, it can affects functional abnormalities related to the minute changes of the brain due to smoking. 흡연 유무의 남성을 대상으로 뇌 회백질의 손상 유무를 파악 할 수 있는 확산텐서영상을 검사하여 영상을 획득 한 후 Tract-Based Spatial Statics(TBSS)방법으로 뇌 회백질 부위의 기저핵 신경섬유로의 비등방도 FA(fractional anisotropy)값을 측정 분석한 결과 모든 영역에서 흡연자가 비흡연자보다 비등방성 측정값이 낮게 관찰되었으며 FA값은 통계적으로 유의하였다. 본 연구의 측정한 FA결과 값으로 추측하자면 즉, 흡연이 뇌 회백질 기저핵의 모든 해부학적 미세 구조성 변화에 크게 영향을 미치며 신경섬유로를 손상시키고 이와 관련된 기능적 이상에 영향을 준다고 할 수 있다.

기저핵 손상 환자에서 인지과제가 뇌파에 미치는 영향

이정원(Jeong Weon Lee),안시내(Si Nae Ahn),김영실(Young Sil Kim) 한국인지운동치료협회 2010 한국신경인지재활치료학회지 Vol.2 No.1

Objective : The purpose of this study was to determine the effects of performance of cognitive task on EEG and attentiveness by comparing alpha wave. Methods : Regarding 9 subjects who among patients with apparent change in basal ganglia due to stroke. According to the conditions of the research task, the relative power of alpha wave was collected by dividing it into background EEG, passive task EEG, and cognitive task EEG. With A1 and A2 as standard electrodes, comparison was held based on calculating the power spectrum such as delta wave(0~3Hz), theta wave(3~8Hz), alpha wave(8~13Hz), beta wave(13~30Hz), gamma wave(30~50Hz), and etc. And it was held through Fast Fourier Transform(FFT) regarding the values in the position of Fp1, Fp2, P3, P4, T3, T4, O1, O2. Results : Alpha wave of all conditions in descriptive statistics amount showed the lowest in left Parietal lobe. And, the total average of alpha wave showed the lowest order of background, passive, and cognitive relative power. Regarding the correlation of the three EEG they all showed high degree of correlation(r=.69~.90). Regarding alpha wave of background and passive brain waves in left Parietal lobe, background wave showed lower average of 3.54 than passive wave(p<.05). Regarding alpha wave of background and cognitive wave in the right Occipital lobe, cognitive wave showed lower average of 25.68 than background wave(p<.05). Conclusion : Viewing the results above, it showed significantly low alpha wave in left Parietal lobe for background and passive EEG, and in the right Occipital lobe for background and cognitive EEG. Therefore, the fact that it showed low alpha wave led to the fact that more attention is required when performing cognitive task. In future studies, studies on CBF or brain image are necessary.

장기저탄소발전전략(LEDS) 기반 부문별 이슈 분석을 통한 탄소중립 핵심기술 도출

배치혜(Chihye Bae),박민희(Minhee Park),김혜진(Hyejin Kim),정혜림(Hyelim Jeong) 한국에너지기후변화학회 2021 한국에너지기후변화학회 학술대회 Vol.2021 No.5

치매가 동반된 특발성 기저핵 석회화 1례

신희영,신일선,Shin, Hee-Young,Shin, Il-Seon 대한생물정신의학회 2006 생물정신의학 Vol.13 No.1

The case of a 66- year-old woman with coexisting idiopathic basal ganglia calcification(IBGC) and dementia was presented. The calcification was detected in bilateral basal ganglia, dentate nucleus, and thalamus by brain imaging. Serum calcium and phosphorus levels were normal. The underlying diseases of calcification of basal ganglia such as parathyroid dysfunction and other infectious, toxic, or metabolic illness were excluded. The patient had memory impairment and frontal executive dysfunction without aphasia, agnosia, apraxia, and visuospatial impairment in neuropsychological test. It suggested that the cognitive impairment might be due to the dysfunction of frontal-subcortical circuit.

기저핵 병변을 보이는 정신장애환자의 임상적 고찰

이길홍,이재우,이영식,나철 大韓神經精神醫學會 1992 신경정신의학 Vol.31 No.4

The neurophysiological basis of psychiatric disorders is, for the most part, unknown. Though the relationship between the dysfunction of basal ganglia and psychiatric disorders is also unknown, the possibility is confirmed by many researchers. The suggestion is that the basal ganglia, acting as an active sensory modulating station, maintain the normal flow of information processing. The dysfunction of the basal ganglia have been implicated in many psychiatric symptoms such as mood disturbance, delusion, hallucination, motor disorder and hypersensitivity. Recently many brain imaging studies, using Positron emission tomography(PET). Single photon emission computed tomography(SPECT) and Magnetic resonance imaging(MRI) are being done eagerly trying to confirm the functional and anatomical changes of various brain region including basal ganglia in vivo. The authors experienced two cases of psychiatric inpatients with basal ganglia lesion detected in computed tomography(CT) scan incidentaly. One showed major depression like symptoms and the other showed schizophrenia-like symptoms. The authors reported two cases with literature review related to basal banglia in psychiatry.

알코올성 케톤산증 환자에서 보이는 대뇌 기저핵 손상 : Case Report

권용실,이해국,박정욱,이정태,이경욱 大韓神經精神醫學會 2004 신경정신의학 Vol.43 No.2

좌반구 뇌졸중후 우울증 환자에서 우반구 뇌경색이 수반된 급속 순환형 이차성 양극성장애 1례

장호균,이호택,백주희,이상연,Chang, Ho-Kyun,Yi, Ho-Taek,Paik, Ju-Hee,Lee, Sang-Yeon 한국정신신체의학회 1998 정신신체의학 Vol.6 No.1

저자들은 뇌졸중후 우울증보다 매우 드물게 발생하는 뇌졸중후 양극성장애 증례를 경험하여 보고하였다. 좌반구 기저핵 뇌경색이후 뇌졸중후 우울증을 앓아오던 환자에서 조증 에피소드가 발병하여 원인을 규명하는 과정에서 자기공명영상을 시행한 결과, 이차성 양극 성장애와 연관되는 것으로 보고되어온 우반구 기저핵의 새로운 뇌경색이 밝혀졌다. 한 환자에서 좌반구 뇌졸중이후 우울증, 우반구 뇌졸중이후 양극성장애의 발생이 시간적 연관성을 보였으며, 한편 뇌졸중후 우울증과 이차성 양극성장애 각각이 병변 위치와 특이한 연관성을 보여주고 있다. 문헌 고찰에 의하면, 이차성 조증이 주로 피질의 병변과 연관성을 보이는 반면, 양극성 장애는 피질하 병변에서 호발하는 것으로 보고되어왔으며, 이차성 조종의 위험인자로는 정신장애의 가족력과 경한 피질하 위축이 제시되었다. 이 증례에서도 우반구 피질하 병변과 경한 피질하 위축이 관찰되었다. 뇌졸중 병변위치와 기분장애의 상관성 및 위험인자에 대한 연구는, 일차성 기분장애의 신경생물학적 연구에 기여할 수 있을 것이며, 임상에서도 뇌졸중 환자의 정신증상 치료에서 조중 유발의 위험성을 인식하는데 도움이 될수 있을 것이다. Authors report a case of poststroke bipolar disorder that occurs much less frequently than poststroke depression(PSD). A MRI study performed to identify the etiology of a secondary manic episode in a patient with preceded PSD after left basal ganglia infarction revealed newly developed right basal ganglia infarction associated with poststroke bipolar disorder. It is interesting to note that (1) the temporal relationship was found between the occurrence of PSD after left hemisphere stroke and the occurrence of poststroke bipolar disorder following right hemisphere stroke, and that (2) the occurrence of PSD and the occurrence of poststroke bipolar disorder are associated with lesion location respectively. It has been reported that bipolar disorders were associated with subcortical lesions of the right hemisphere, whereas right-cortical lesions led to unipolar mania and that risk factors for mania included a family history of psychiatric disorders and mild subcortical atrophy. In this case, MR image shows subcortical lesions of the right hemisphere and mild subcortical atrophy. The investigation of the relationships among stroke lesion locations and potstroke mood disorders and risk factors for poststroke bipolar disorder may contribute to understanding the neurobiology of primary mood disorder. A clinical implication is that the risk of secondary bipolar disorder after cerebral infarction should be highlighted.

Tourette 장애 소년에서 자기공명영상을 이용한 기저핵의 용적 분석

선우영경,신용범,이명지,김지영,배재남,강민희,김철응,이정섭 大韓神經精神醫學會 2008 신경정신의학 Vol.47 No.4

Objectives : The purpose of this study was to investigate the regional differences of the basal ganglia volume between the boy subjects who have Tourette's disorder and the control group who don't have this disorder by using Brain MRI. Methods : Sixteen subjects who were diagnosed as Tourette's disorder using DSM-IV criteria, and sixteen healthy subjects were selected. For analysis the coronal slice images of the basal ganglia were collected and collected MR images were analyzed with NIH Image (version 6.1 ppc). Resuls : The total brain volume in the subjects with Tourette's disorder were smaller than control group by 6.2% (F=6.2, d.f.=1, P=0.019). The right putamen volume in boys with Tourette's disorder were significant smaller than control group statistically (F=3.2, d.f.=3, P=0.040). The asymmetry (1eft>right) in the globus pallidus decreased significantly in the boys with Tourette's disorder (p=0.06) were found from this experiment. Conclusion : These findings suggest that boys with Tourette's disorder may have neuropathological abnormalities in the basal ganglia. Moreover, the present findings point out the important role of basal ganglia, especially putamen, in Patho-physiology of Tourette's disorder. More studies about the structural and functional analysis of the basal ganglia in Tourette's disorder are highly required.

64 다중채널 검출기 전산화단층촬영에서 환자고정자 재질에 대한 영상평가

김기복,구은회 한국융합학회 2016 한국융합학회논문지 Vol.7 No.1

본 실험의 목적은 두부 팬텀 MDCT에서 5 종류의 환자고정자 패드를 이용하여 노이즈, 신호대 잡음비, 선량에 대하여 방사선감수성이 민감한 안와 와 기저핵 부위를 기준으로 영상의 질을 평가하고자 하였다. 영상의 노이즈는 AP가 가장 높게 나타났으며, 신호대 잡음비는 가장 낮게 나타났다. 환자고정자 재료 5(UP, RP, PP SP, AP) 종류 중 신호대 잡음비가 가장 높은 것은 UP 이었지만 RP, PP와 더불어 통계적 유의성이 없었고(p>0.05), UP, RP, PP와 SP, AP는 통계적 유의성이 있었다(p<0.05). 이러한 원인은 방사선을 입사했을 때 SOML의 기준선에 따른 검출기의 흡수선량정도와 각각의 재질의 성분에 따라 방사선 흡수선량이 다르기 때문에 노이즈 차이를 발생하게 된다. 안와 기저핵의 CTDIvol(mGy)와 DLP 값은 각각 56.95, 911.50로 환자고정자 재료에 따라 선량의 차이는 없었다. 결론적으로, 5 종류의 환자고정자 패드는 각각의 차이를 구별할 수 있었으며 SP, AP 보다 UP, RP, PP 사용은 임상적으로 유용한 정보를 제공할 수 있다. The purpose of this experiment intend to evaluate the quality of the image based on the orbit and basal ganglia with high radiosensitivity for the noise, SNR and dose using the five kinds patient fixing pad in brain phantom MDCT(Brilliance™ CT 64 slice, PHILIPS, Netherward). The noise had a higher values in AP than those of others, but the SNR was lower in AP than those of others. The SNR was higher in UP than those of RP, PP, SP and AP. The UP, RP and PP were no statistically significant(p>0.05), whereas it was significant difference between UP, RP, PP and SP, AP(p<0.05). This is causes of the noise difference is generated due to the differences in the radiation absorption dose in accordance with each the component of the absorbed dose level of the detector according to the reference line and each of SOML when the radiation exposured. The CTDIvol(mGy) and DLP of orbit and basal ganglia were 56.95, 911.50, respectively. There is no difference between both mean dose. In conclusion, it is possible to distinguish among a kind of 5 patient fixing pad by using brain phantom MDCT. Overall, patient fixing pad of UP, RP and PP based on a brain phantom MDCT can provide useful information.