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Park, J. M.,Choi, M.-G.,Kim, S. W.,Chung, I.-S.,Yang, C. W.,Kim, Y. S.,Jung, C. K.,Lee, K. Y.,Kang, J.-H. Wiley (Blackwell Publishing) 2010 American journal of transplantation Vol.10 No.9
<P>This study was to evaluate the frequency of colorectal neoplasia in renal transplant recipients and to investigate the association with Epstein-Barr virus (EBV) and cytomegalovirus (CMV) infection. We compared the frequency of colorectal neoplasia among renal transplant recipients with that of the healthy subjects. Specimens of colorectal neoplasia were examined for EBV and CMV using in situ hybridization and immunohistochemistry, respectively. Of 796 renal transplantation cohorts, 315 were enrolled. The frequency of colorectal neoplasia among the patients was 22.9%. Compared with the healthy subjects, the odds ratio (OR) for advanced adenoma was 3.32 (95% CI, 1.81-6.10). The frequency of cancer among the patients was 1.9% (OR, 12.0; 95% CI, 1.45-99.7). A long interval between transplantation and colonoscopy was a significant factor in the development of advanced colorectal neoplasia. EBV positivity was detected in 30.6% of colorectal neoplasia specimens from renal transplant recipients, which was higher than that for the controls (p = 0.002). CMV was not detected in any lesions of patients or controls. In conclusion, renal transplant recipients have a significantly increased risk of advanced colorectal neoplasia. EBV was more frequently found in specimens of advanced colorectal neoplasm obtained from the renal transplant recipients.</P>
Choi, Yun-Seok,Youn, Ho-Joong,Park, Chul-Soo,Oh, Yong-Seog,Chung, Wook-Sung,Kim, Jae-Hyung Wiley (Blackwell Publishing) 2009 Echocardiography Vol.26 No.2
<P>BACKGROUND: Detection of subclinical, nonobstructive coronary artery disease will require the evaluation of coronary arterial walls and external coronary diameter in order to detect increases in arterial wall thickness and compensatory remodeling before luminal narrowing. We assessed the meaning of high echogenic thickening (HET) on transthoracic coronary echogram of proximal coronary arteries and evaluated whether HET predicts the severity of coronary artery disease on angiogram. METHODS: Ninety-seven patients (M:F = 61:36, mean age = 61+/-8 years) referred for coronary angiography were included in this study. We detected proximal coronary artery using transthoracic coronary echogram. We defined that HET is more than 1.5 mm in thickness with high echogenicity and persistence. Of these patients, 29 vessels were examined by IVUS (intravascular ultrasound). RESULTS: (1) HET on coronary echogram had a sensitivity of 44.4% and specificity of 95% for identifying calcification on IVUS. (2) HET had a sensitivity of 73.5% and specificity of 85.7% for identifying the significant stenosis of proximal left coronary artery. (3) HET was observed more frequently in three-vessel diseases and more complex lesion compared to normal and one- or two-vessel diseases (P < 0.05, respectively). CONCLUSION: HET may be related to the presence of calcification and predicts far advanced coronary atherosclerosis.</P>
Suh, Soon Yong,Kim, Eung Ju,Choi, Cheol Ung,Na, Jin Oh,Kim, Sung Hea,Kim, Hyun Joong,Han, Seong Woo,Chung, Sang Man,Ryu, Kyu Hyung,Park, Chang Gyu,Seo, Hong Seog,Oh, Dong Joo Wiley (Blackwell Publishing) 2009 Echocardiography Vol.26 No.9
<P>BACKGROUND: Aortic stiffening contributes to the left ventricular (LV) afterload, hypertrophy, and substrate for diastolic dysfunction. It is also known that aortic elastic properties could be investigated with color tissue Doppler imaging (TDI) in aortic upper wall. The purpose of this study is to evaluate the relation of aortic upper wall TDI and aortic stiffness and other parameters of LV diastolic function. METHODS: We examined aortic upper wall by TDI at the 3 cm above the aortic valves because of patient's chest discomfort or dyspnea. We excluded the patient with arterial hypertension or reduced left ventricular ejection fraction (LVEF) or significant valvular heart disease. So a total of 126 (mean age 53.8 +/- 13.9 years, male 49.2%) patients were enrolled in this study and divided normal LV filling group (N = 31) and abnormal LV filling group (N = 95). RESULTS: Aortic upper wall early systolic velocity and late diastolic velocity were not different between the two groups. Only aortic upper wall early diastolic velocity (AWEDV) was related to aortic stiffness index (r =-0.25, P = 0.008), distensibility (r = 0.28, P = 0.003), early diastolic (Em) (r = 0.45, P = 0.001), E/Em (r =-0.26, P = 0.003), and significantly reduced in abnormal LV filling group (6.19 +/- 2.50 vs 8.18 +/- 2.87, P = 0.001). CONCLUSIONS: AWEDV is decreased significantly in abnormal LV filling patients. It is statistically related to aortic stiffness, distensibility and parameters of abnormal LV filling, Em, E/Em. TDI velocity of the aortic upper wall can be a helpful tool for evaluating aortic stiffness, distensibility, and diastolic function.</P>
Lee, Byung In,Yi, Sangdoe,Hong, Seung Bong,Kim, Myeong-Kyu,Lee, Sang Ahm,Lee, Sang Kun,Shin, Dong-Jin,Kim, Jae Moon,Song, Hong Ki,Heo, Kyoung,Lowe, Wing,Leon, Teresa Wiley (Blackwell Publishing) 2009 Epilepsia Vol.50 No.3
<P>To evaluate the efficacy and safety of pregabalin (PGB) as adjunctive therapy, using a flexible-dosing schedule in Korean patients with refractory partial-onset seizures.</P>
Seo, Sang Won,Cho, Sang Soo,Park, Aram,Chin, Juhee,Na, Duk L. Wiley (Blackwell Publishing) 2009 JOURNAL OF NEUROIMAGING Vol.19 No.3
<P>BACKGROUND AND PURPOSE: Most studies on mild cognitive impairment (MCI) have been focused on amnestic MCI (aMCI) that is the preclinical stage of Alzheimer's disease (AD). In contrast, only a few studies have involved patients in the preclinical stages of subcortical vascular dementia (subcortical vascular MCI, svMCI). We tried to compare the overall glucose metabolism in patients with svMCI with that of patients with aMCI. METHODS: We compared the regional metabolic patterns shown on 18 F-FDG (fluro deoxy glucose) positron emission tomography (PET) images from 18 patients with svMCI with those from 25 aMCI patients matched for age, sex, education, and mini-mental state examination (MMSE) score and with those from 35 healthy subjects using a voxel-wise analysis. SPM 2 was used for statistical analysis. RESULTS: Relative to normal controls, the hypometabolic regions in the aMCI patients were in the bilateral parahippocampal, bilateral posterior cingulate, left superior temporal gyri, left inferior parietal lobule, and right inferior frontal gyrus while those in the svMCI patients were located in the thalamus, insula, superior temporal gyrus, anterior cingulate gyrus, cingulum, right basal ganglia, cerebellum, and brainstem. A direct comparison of glucose metabolism between svMCI and aMCI showed that the glucose hypometabolism in patients with svMCI was more severe in the thalamus, brainstem, and cerebellum. CONCLUSION: Our study suggested that svMCI was distinct from aMCI in terms of neuropsychological and PET findings, which may explain their clinical manifestations.</P>
Kim, Hee-Jin,Sohn, Ju-Tae,Jeong, Young-Seok,Cho, Man Seok,Kim, Hye Jung,Chang, Ki Churl,Shin, Mi-Kyung,Park, Chang-Shin,Chung, Young-Kyun Wiley (Blackwell Publishing) 2009 Clinical and Experimental Pharmacology & Physiolog Vol.36 No.4
<P>1. The aims of the present in vitro study were to examine the roles of pathways associated with arachidonic acid metabolism in dexmedetomidine-induced contraction and to determine which endothelium-derived vasodilators are involved in the endothelium-dependent attenuation of vasoconstriction elicited by dexmedetomidine. 2. Dexmedetomidine (10(-9)-10(-6) mol/L) concentration-response curves were constructed in: (i) aortic rings with no drug pretreatment; (ii) endothelium-denuded aortic rings pretreated with either 2 x 10(-5) mol/L quinacrine dihydrochloride, 10(-5) mol/L nordihydroguaiaretic acid (NDGA), 3 x 10(-5) mol/L indomethacin or 10(-5) mol/L fluconazole; and (iii) endothelium-intact aortic rings pretreated with either 5 x 10(-5) mol/L N(G)-nitro-l-arginine methyl ester (l-NAME), 10(-5) mol/L fluconazole, 10(-5) mol/L indomethacin, 10(-5) mol/L glibenclamide, 5 x 10(-3) mol/L tetraethylammonium or 5 x 10(-5) mol/L l-NAME plus rauwolscine (10(-5), 10(-6) mol/L). The production of nitric oxide (NO) metabolites was determined in human umbilical vein endothelial cells treated with dexmedetomidine. 3. Quinacrine dihydrochloride, NDGA and indomethacin attenuated the dexmedetomidine-induced contraction of endothelium-denuded rings. Dexmedetomidine (10(-7)-10(-6) mol/L)-induced contractions of endothelium-denuded rings were enhanced compared with those of endothelium-intact rings, as were dexmedetomidine-induced contractions of endothelium-intact rings pretreated with l-NAME or tetraethylammonium. Rauwolscine attenuated dexmedetomidine-induced contractions in endothelium-intact rings pretreated with l-NAME. Dexmedetomidine (10(-6) mol/L) was found to activate NO production. 4. Taken together, the results indicate that dexmedetomidine-induced contraction of aortic rings involves activation of the lipoxygenase and cyclo-oxygenase pathways and is attenuated by increased NO production following stimulation of endothelial alpha(2)-adrenoceptors by dexmedetomidine.</P>