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A Case of Cutaneous Metastasis Originating from Thymic Carcinoma
Choi, Suk Jin,Rho, Nark Kyoung,Yang, Jun Mo,Lee, Eil Soo The Korean Dermatological Association 2002 Annals of Dermatology Vol.14 No.4
We report a case of cutaneous metastasis of thymic carcinoma in Korean. A 44-year-old female, who had been diagnosed as thymic carcinoma and treated with total thymectomy and postoperative radiation therapy, presented grouped erythematous papules on the left chest. CT scans revealed metastatic lesions in the left pleura and abdominal cavity. Histopathologic examination of skin biopsy showed extensive infiltration of malignant cells in dermis and subcutis. The morphology of infiltrating cells was similar to that of tumor cells from primary thymic carcinoma specimen. The results of immunohistochemical study for skin biopsy were consistent with the features of non-neuroendocrine thymic carcinoma. Histopathologic and immunohistopathologic similarity between cutaneous lesion and previous tumor suggested that malignant cells in the skin lesion could originate from progressing thymic carcinoma.
Acral-type Malignant Acanthosis Nigricans Associated with Gastric Adenocarcinoma
Lee, Sang-Sin,Jung, Nam-Ji,Im, Myung,Lee, Young,Seo, Young-Joon,Lee, Jeung-Hoon Korean Dermatological Association; The Korean Soci 2011 Annals of Dermatology Vol.23 No.suppl2
<P>Acanthosis nigricans is a symmetric eruption characterized by the presence of a hyperpigmented, velvety cutaneous thickening, that can develop on any part of the body, but characteristically affects the flexural areas of the body. The velvety hyperkeratotic lesions can be located on the dorsum of the hands and feet in dark-skinned people in the form of a variant of acanthosis nigricans called as acral acanthotic anomaly or acral type acanthosis nigricans. Although acanthosis nigricans is associated with malignant tumors, particularly gastric carcinoma, acral type acanthosis nigricans has never been reported to be associated with gastric adenocarcinoma. In our present study, we describe a case of 58-year-old man with acral type acanthosis nigricans and its association with carcinoma of the stomach; a marked improvement was seen in the skin condition of the patient with chemotherapy.</P>