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DNA methylation-specific multiplex assays for body fluid identification.
An, Ja Hyun,Choi, Ajin,Shin, Kyoung-Jin,Yang, Woo Ick,Lee, Hwan Young Springer International ; Springer 2013 International journal of legal medicine Vol.127 No.1
<P>Recent advances in whole-genome epigenetic analysis indicate that chromosome segments called tissue-specific differentially methylated regions (tDMRs) show different DNA methylation profiles according to cell or tissue type. Therefore, body fluid-specific differential DNA methylation is a promising indicator for body fluid identification. However, DNA methylation patterns are susceptible to change in response to environmental factors and aging. Therefore, we investigated age-related methylation changes in semen-specific tDMRs using body fluids from young and elderly men. After confirming the stability of the body fluid-specific DNA methylation profile over time, two different multiplex PCR systems were constructed using methylation-sensitive restriction enzyme PCR and methylation SNaPshot, in order to analyze the methylation status of specific CpG sites from the USP49, DACT1, PRMT2, and PFN3 tDMRs. Both multiplex systems could successfully identify semen with spermatozoa and could differentiate menstrual blood and vaginal fluids from blood and saliva. Although including more markers for body fluid identification might be necessary, this study adds to the support that body fluid identification by DNA methylation profiles could be a valuable tool for forensic analysis of body fluids.</P>
Park, Sang Min,Son, Ki Young,Park, Jae-Hyun,Cho, Belong Springer International ; Springer 2012 SUPPORTIVE CARE IN CANCER Vol.20 No.5
<P>This study was conducted in order to determine whether a gap exists between cancer patients with disabilities and those without disabilities with regard to short-term and long-term all-cause mortality in Korea.</P>
Lee, Jong Hoon,Kim, Sung Hwan,Jang, Hong Seok,Chung, Hyuk Jun,Oh, Seong Taek,Lee, Doo Seok,Kim, Jun-Gi Springer International ; Springer-Verlag, distribu 2013 International journal of colorectal disease Vol.28 No.4
<P>This study was conducted to evaluate the significance of carcinoembryonic antigen (CEA) level as a predictor for tumor response to chemoradiotherapy (CRT) and a prognosticator for survival in Asian patients with advanced rectal cancer.</P>
Ahn, Chul Won,Kwon, Do Young,Jun, Doo Sung,Lee, Yoo Min,Kim, Young Chul Springer-Verlag ; Springer 2015 Amino acids Vol.47 No.6
<P>We determined the alterations in metabolic conversion of cysteine into glutathione and taurine in liver of rats treated with ethanol acutely. Ethanol treatment reduced cysteine as well as glutathione levels in liver for 24 h. However, cysteine dioxygenase was up-regulated rapidly, and hypotaurine/taurine levels were significantly higher than those found in the saline-treated rats. It is therefore suggested that enhancement of cysteine catabolism into taurine contributes to the depletion of hepatic glutathione, which could exacerbate the ethanol-induced oxidative liver injury.</P>
Jung, Hee-Won,Kim, Jin Won,Kim, Ji-Yeon,Kim, Sun-Wook,Yang, Hyun Kyung,Lee, Joon Woo,Lee, Keun-Wook,Kim, Duck-Woo,Kang, Sung-Bum,Kim, Kwang-Il,Kim, Cheol-Ho,Kim, Jee Hyun Springer International ; Springer 2015 SUPPORTIVE CARE IN CANCER Vol.23 No.3
<P>The purpose of this study was to elucidate the effect of decreased muscle mass on the toxicity and survival of patients with colon cancer treated with adjuvant chemotherapy after surgery.</P>
Hwang, In Cheol,Ahn, Hong Yup,Park, Sang Min,Shim, Jae Yong,Kim, Kyoung Kon Springer International ; Springer 2013 Supportive Care in Cancer Vol.21 No.3
<P>There is scant research concerning the prediction of imminent death, and current studies simply list events 'that have already occurred' around 48 h of the death. We sought to determine what events herald the onset of dying process using the length of time from 'any change' to death.</P>
Coronary ostial stenosis after aortic valvuloplasty (comprehensive aortic root and valve repair)
Han, S.W.,Kim, H.J.,Kim, S.,Ryu, K.H. Springer International ; Springer-Verlag New York 2009 European journal of cardio-thoracic surgery Vol.35 No.6
Comprehensive aortic root and valve repair (CARVAR) surgery using specially designed aortic rings was introduced as a new surgical technique for aortic valve disease. We present five consecutive cases of iatrogenic coronary ostial stenosis after CARVAR surgery in patients with aortic stenosis. The preoperative coronary angiography confirmed that all the patients had normal coronary arteries. They underwent aortic valvuloplasty by aortic leaflet extension and insertion of specially designed inner and outer rings at the level of the sinotubular junction. Within 6 months after surgery, all the patients complained of resting chest pain and dyspnea with changes of electrocardiography. Repeated coronary angiography demonstrated right coronary artery (RCA) ostial stenosis in one patient and left main (LM) ostial stenosis in the other four patients. Intravascular ultrasonography demonstrated severe ostial stenosis and extensive echogenic tissue in the extravascular area. Four patients with LM ostial disease successfully underwent coronary bypass graft surgery, and percutaneous coronary intervention with stenting was performed in one case of RCA ostial stenosis. Because the mechanism of this complication is not fully confirmed, more clinical study is required to confirm the safety issues of CARVAR surgery.
Hwang, In-Chang,Kim, Yong-Jin,Kim, Kyung-Hee,Lee, Seung-Pyo,Kim, Hyung-Kwan,Sohn, Dae-Won,Oh, Byung-Hee,Park, Young-Bae Springer International ; Springer-Verlag New York 2013 European journal of cardio-thoracic surgery Vol.43 No.1
<P>The prognostic value of B-type natriuretic peptide (BNP) for surgical outcome in patients with mitral regurgitation (MR) has not been studied. The purpose of this study was to determine the prognostic value of BNP in patients with chronic severe MR, undergoing mitral valve surgery.</P>
Cho, K.R.,Choi, J.S.,Hahn, W.,Kim, D.S.,Park, J.S.,Lee, D.S.,Kim, K.B. Springer International ; Springer-Verlag New York 2008 European journal of cardio-thoracic surgery Vol.34 No.4
Objective: We evaluated the potency of therapeutic angiogenesis using intramyocardial injection of naked DNA expressing two isoforms of hepatocyte growth factor (pCK-HGF-X7) in a porcine myocardial infarction model. Methods: Four weeks after left anterior descending coronary artery ligation, 14 pigs were allocated to pCK-Null (negative control, n=7) or pCK-HGF-X7 (n=7) treatment groups. Gated myocardial single photon emission computed tomography was performed 4 and 8 weeks following coronary ligation. The effect of pCK-HGF-X7 on capillary density in the gene-injected myocardium was examined by histological analysis using alkaline phosphatase staining. Results: Segmental myocardial perfusion of the underperfused area (@?70%) from coronary ligation increased in the pCK-HGF-X7 group (p=0.051), without significant differences in changes over time between the two groups (p=0.54). Systolic wall thickening (p=0.001), left ventricular end-diastolic (p=0.045) and end-systolic volumes (p=0.009), and left ventricular ejection fraction (p=0.041) changed in both groups without significant differences in changes over time between the two groups. The increase in the left stoke volume was higher in the pCK-HGF-X7 group than in the pCK-Null group (p=0.008). Histological analysis showed that capillary density was significantly higher in the pCK-HGF-X7 group than the pCK-Null group (p<0.001). Conclusion: Intramyocardial injection of pCK-HGF-X7 induced significant angiogenesis at infarct-border zone, and increased the left ventricular stroke volume probably caused by reverse remodeling process.