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Kim, Gwang-Won,Jeong, Gwang-Woo Rapid Communications of Oxford Ltd 2014 NEUROREPORT - Vol.25 No.12
<P>Residential environments are important in the daily lives of individuals, especially in terms of cognitive psychophysiology. This study compared the neural responses to two extreme residential environments: comfortable versus uncomfortable. Thirteen healthy individuals underwent a 3.0-T functional MRI while viewing images representing comfortable and uncomfortable residential environments. During exposure to the comfortable scenery, significant activation was observed in the calcarine gyrus selectively, whereas the uncomfortable scenery induced significant activation in the ventrolateral prefrontal cortex and anterior cingulate cortex, which are related to cognitive control, as well as in the medial prefrontal cortex, hippocampus, parahippocampal gyrus, amygdala, and insula, which are involved in the regulation and expression of emotion. Such differential brain activation patterns may reflect the neural networks mediating cognitive and emotional responses to residential environments. These findings would be helpful for understanding the neural mechanism associated with human comfortability for their residential environments.</P>
Association of colorectal adenoma with components of metabolic syndrome.
Kim, Byung Chang,Shin, Aesun,Hong, Chang Won,Sohn, Dae Kyung,Han, Kyung Su,Ryu, Kum Hei,Park, Bum Joon,Nam, Ji Hyung,Park, Ji Won,Chang, Hee Jin,Choi, Hyo Seong,Kim, Jeongseon,Oh, Jae Hwan Rapid Communications of Oxford Ltd ; Kluwer Academ 2012 Cancer causes & control Vol.23 No.5
<P>Recently, some studies have shown that diabetes mellitus and metabolic syndrome increase the risk of colorectal neoplasms. Although the mechanism is not known, those have been proposed to contribute to this phenomenon, including insulin resistance, oxidative stress, and adipokine production. The objective of this study was to assess the association between metabolic risk factors and colorectal neoplasm.</P>
Oh, Chung-Hun,Shin, Jang-In,Mo, Sang Joon,Yun, Sung-Jo,Kim, Sung-Hoon,Rhee, Yun-Hee Rapid Communications of Oxford Ltd 2013 Blood coagulation & fibrinolysis Vol.24 No.5
<P>L-sulforaphane was identified as an anticarcinogen that could produce quinine reductase and a phase II detoxification enzyme. In recent decades, multi-effects of L-sulforaphane may have been investigated, but, to the authors' knowledge, the antiplatelet activation of L-sulforaphane has not been studied yet.In this study, 2 μg/ml of collagen, 50 μg/ml of ADP and 5 μg/ml of thrombin were used for platelet aggregations with or without L-sulforaphane. L-sulforaphane inhibited the platelet aggregation dose-dependently. Among these platelet activators, collagen was most inhibited by L-sulforaphane, which markedly decreased collagen-induced glycoprotein IIb/IIIa activation and thromboxane A2 (TxA2) formation in vitro. L-sulforaphane also reduced the collagen and epinephrine-induced pulmonary embolism, but did not affect prothrombin time (PT) in vivo. This finding demonstrated that L-sulforaphane inhibited the platelet activation through an intrinsic pathway.L-sulforaphane had a beneficial effect on various pathophysiological pathways of the collagen-induced platelet aggregation and thrombus formation as a selective inhibition of cyclooxygenase and glycoprotein IIb/IIIa antagonist. Thus, we recommend L-sulforaphane as a potential antithrombotic drug.</P>
Kim, Byung-Su,Bae, Eunkyung,Kim, Young-Ju,Ahn, Kwang-Sung,Park, Juwon,Rhee, Ji young,Lee, Young Yiul,Kim, Youngsoo,Lee, Dongsoon,Kim, Byoung Kook,Yoon, Sung-Soo RAPID COMMUNICATIONS OF OXFORD LTD 2007 ANTICANCER DRUGS Vol.18 No.6
Although STI571 still plays a key role in the treatment of chronic myeloid leukemia, emergence of resistance to STI571 is a major obstacle to successful outcome. Therefore, new agents that increase the sensitivity of chronic myeloid leukemia cells to STI571 are urgently required. SK-7041 is a novel hybrid synthetic histone deacetylase inhibitor derived from the hydroxamic acid of trichostatin A and pyridyl ring of MS-275. Its cytotoxic effects were examined both as a single agent and in combination with STI571 in acute and chronic myeloid leukemia. SK-7041 exhibited growth inhibition of leukemia cells by downregulation of CDK4, cyclin E and cyclin B1 expression, and by upregulation of p21 expression with subsequent activation of the mitochondria-mediated caspase pathway. SK-7041 showed synergism on growth inhibition, cell cycle arrest and induction of apoptosis in chronic myeloid leukemia (K562) when combined with STI571. The synergistic effect was mediated through the same mechanism as in SK-7041 alone, involving reduction of cyclin D1 and induction of p21. Taken together, our findings suggest that SK-7041 is active against leukemia and offers new prospects for overcoming STI571 resistance in chronic myeloid leukemia.
Lee, Kyunghoon,Kim, Ji-Eun,Kwon, Jihyun,Kim, Inho,Yoon, Sung-Soo,Park, Seonyang,Han, Kyou-Sup,Kim, Hyun Kyung Rapid Communications of Oxford Ltd 2014 Blood coagulation & fibrinolysis Vol.25 No.3
Overall assessment of the hemostatic system including procoagulant and anticoagulant changes may help assess the clinical status and prognosis of disseminated intravascular coagulation (DIC). The thrombin generation assay provides useful information about the global hemostatic status. Therefore, we measured several parameters of global hemostatic potential by the thrombin generation assay in patients suspected of having DIC. A total of 114 patients with suspected DIC were included. The thrombin generation assay was performed on the calibrated automated thrombogram using tissue factor with or without the addition of thrombomodulin, showing three parameters: lag time, endogenous thrombin potential (ETP), and peak thrombin. Both 1 and 5 pmol/l tissue factor-stimulated ETP and peak thrombin were well correlated with DIC severity. Interestingly, antithrombin level greatly affected ETP, whereas protein C influenced lag time. Prognostic analysis revealed that the area under the curve of peak thrombin stimulated by 1 pmol/l tissue factor was superior to that of D-dimer. Moreover, multivariate Cox analysis showed that the lag time and time to peak with both 1 and 5 pmol/l tissue factor were independent prognostic markers. ETP and peak thrombin well reflect DIC severity. Hypocoagulability manifesting as prolonged lag time and time to peak is expected to be an independent prognostic marker in DIC.
Kim, Hyun Kyung,Kim, Ji-Eun,Chung, Junho,Kim, Young Tae,Kang, Seong-Ho,Han, Kyou-Sup,Cho, Han-Ik Rapid Communications of Oxford Ltd 2007 Blood coagulation & fibrinolysis Vol.18 No.2
Thrombomodulin has a central role in the regulation of coagulation through its abilities to promote generation of the potent anticoagulant activated protein C. Because little is known about monocyte thrombomodulin expression and its regulatory mechanism by lipopolysaccharide, we investigated the effect of lipopolysaccharide on monocyte’s thrombomodulin expression. Lipopolysaccharide reduced the surface thrombomodulin expression of human peripheral blood monocytes in a dose-dependent and time-dependent manner, regardless of the addition of serum. The surface thrombomodulin activity was comparably decreased in monocytes incubated with lipopolysaccharide. Blocking nuclear factor-&kgr;B by MG132 or aurine tricarboxylic acid effectively inhibited the lipopolysaccharide-induced surface thrombomodulin down-regulation of monocytes. Lipopolysaccharide inactivation by polymyxin B in the supernatants from the lipopolysaccharide-stimulated cultures still reduced the surface thrombomodulin expression of monocytes, suggesting a role for soluble mediators in the down-regulation of thrombomodulin. The lipopolysaccharide-induced thrombomodulin surface expression and the mRNA levels of the monocytic leukemic cell line (THP-1) were decreased in serum-depleted culture, while they were increased in medium containing 10% serum. We conclude that lipopolysaccharide down-regulates the thrombomodulin expression of monocytes and that nuclear factor-&kgr;B is a critical mediator of the repression of thrombomodulin by lipopolysaccharide. Regulation of the THP-1 thrombomodulin expression by lipopolysaccharide depends on the presence of serum.
Lipoic acid rescues DBA mice from early-onset age-related hearing impairment.
Ahn, Joong Ho,Kang, Hun Hee,Kim, Tae Yong,Shin, Jung-Eun,Chung, Jong Woo Rapid Communications of Oxford Ltd 2008 NEUROREPORT - Vol.19 No.13
<P>We fed DBA mice with alpha-lipoic acid (100 mg/kg body weight/day), beginning 2, 4, or 8 weeks after birth. Hearing thresholds were measured weekly. At 12 weeks after birth, control mice not fed with alpha-lipoic acid showed significant hearing decreases at all frequencies. In contrast, mice fed with alpha-lipoic acid beginning at 2 weeks after birth showed significantly better hearing at all frequencies. Mice fed with alpha-lipoic acid beginning at 4 and 8 weeks after birth also showed significantly better hearing than control mice after they were fed with alpha-lipoic acid. The stria vascularis of mice fed with alpha-lipoic acid showed reduced 8-oxoguanine residues in DNA and cytoplasm compared with that of control mice. Western blotting showed that the level of hypoxia-inducible factor-1alpha was lower in mice fed with alpha-lipoic acid than in control mice. From these results, we suggest that alpha-lipoic acid prevented early-onset hearing impairment in DBA mice.</P>
Ecological study for refrigerator use, salt, vegetable, and fruit intakes, and gastric cancer.
Park, Boyoung,Shin, Aesun,Park, Sue K,Ko, Kwang-Pil,Ma, Seung Hyun,Lee, Eun-Ha,Gwack, Jin,Jung, En-Joo,Cho, Lisa Y,Yang, Jae Jeong,Yoo, Keun-Young Rapid Communications of Oxford Ltd ; Kluwer Academ 2011 Cancer causes & control Vol.22 No.11
<P>We used an ecological approach to determine the correlation between vegetable, fruit and salt intakes, refrigerator use, and gastric cancer mortality in Korean population. Information on fruit and vegetable intakes per capita from the National Health and Nutrition Survey, death certificate data from the National Statistical office, refrigerator per household data from Korean Statistical Information Service, and salt/sodium intake data from a cross-sectional survey were utilized. Correlation coefficients were calculated between vegetable and fruit intakes, refrigerator per household, and gastric cancer mortality and between salt and sodium intakes, and gastric cancer mortality and incidence in the four areas. With 5, 10, and 15?years lag time, refrigerator usage and fruit intake were negatively associated with gastric cancer mortality (p?<?0.01), but vegetable intake was not associated with gastric cancer mortality. When estimates of salt/sodium intake evaluated by 24-h urine collection in four areas of Korea were compared to the gastric cancer mortality and incidence in these regions, positive correlation was shown between salt/sodium intake, and gastric cancer incidence and mortality. Negative associations between refrigerator use, fruit intake, and gastric cancer mortality and positive associations between salt/sodium intake and gastric cancer mortality and incidence were suggested.</P>