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Woo, In Sook,Hong, Sook Hee,Byun, Jae Ho,Kang, Jin-Hyung,Jeon, Hae-Myung,Choi, Myung Gyu Marcel Dekker 2008 Cancer investigation Vol.26 No.3
<P>This study was conducted to investigate the value of the pretreatment circulating stromal cell derived factor-1alpha(SDF-1alpha) in patients with gastric carcinoma. We measured SDF-1alpha serum concentrations and evaluated the relationship between serum SDF-1alpha and serum vascular endothelial growth factor (VEGF) levels and clinical factors in 107 gastric cancer patients. Serum levels of SDF-1alpha and VEGF levels were higher in gastric cancer patients than in controls (p < 0.001). Serum SDF-1alpha levels were higher in metastatic patients than non-metastatic patients (p < 0.001). SDF-1alpha levels were correlated with the presence of distant metastases (r = 0.528; p < 0.001) and correlated with VEGF levels (r = 0.789; p < 0.001). SDF-1alpha might serve as a possible marker for predicting or monitoring distant metastasis in gastric carcinoma.</P>
WDNM1 is associated with differentiation and apoptosis of mammary epithelial cells.
Kho, Yoonjung,Kim, Sungchan,Yoon, Byung Sun,Moon, Jai-Hee,Kwak, Sungwook,Park, Gyuman,Woo, Junghee,Oh, Sejong,Hong, Kichang,Kim, Saehun,Kim, Hyunggee,You, Seungkwon,Choi, Yunjaie Marcel Dekker 2008 Animal biotechnology Vol.19 No.2
<P>In this study, we show that expression of the Westmead DMBA8 nonmetastatic cDNA 1 (WDNM1) gene was increased upon SFM and/or TNFalpha treatment, with a corresponding increase in apoptotic cells, and gradually decreased following re-stimulation with serum in HC11 mammary epithelial cells. TNFalpha induced WDNM1 expression showed the NFkappaB-dependent mechanism since it's expression was abrogated in IkappaBalphaM (super-repressor of NFkappaB)-transfected cells, but not those transfected with control vector. Furthermore, overexpression of WDNM1 suppressed growth and differentiation, and accelerated apoptosis of HC11 cells. Thus, our results demonstrate that WDNM1 gene expression, regulated by the TNFalpha-NFkappaB signal pathway, is associated with HC11 cell apoptosis.</P>
Bio-dissolution of Ni, V and Mo from spent petroleum catalyst using iron oxidizing bacteria.
Pradhan, Debabrata,Kim, Dong J,Roychaudhury, Gautam,Lee, Seoung W Marcel Dekker 2010 Journal of Environmental Science and Health. Part Vol.45 No.4
<P>Bioleaching studies of spent petroleum catalyst containing Ni, V and Mo were carried out using iron oxidizing bacteria. Various leaching parameters such as Fe(II) concentration, pulp density, pH, temperature and particle size were studied to evaluate their effects on the leaching efficiency as well as the kinetics of dissolution. The percentage of leaching of Ni and V were higher than Mo. The leaching process followed a diffusion controlled model and the product layer was observed to be impervious due to formation of ammonium jarosite (NH(4))Fe(3)(SO(4))(2)(OH)(6). Apart from this, the lower leaching efficiency of Mo was due to a hydrophobic coating of elemental sulfur over Mo matrix in the spent catalyst. The diffusivities of the attacking species for Ni, V and Mo were also calculated.</P>
Lee, Hong-Seok,Park, Yong-Moon,Kwon, Hyuk-Sang,Lee, Jin-Hee,Park, Young Joon,Lim, Sun Young,Lee, Seung-Hwan,Yoon, Kun-Ho,Son, Ho-Young,Kim, Dong Suk,Yim, Hyeon Woo,Lee, Won-Chul Marcel Dekker, Inc 2010 Clinical and experimental hypertension Vol.32 No.3
<P>The present study was aimed to assess the prevalence, awareness, treatment, control of hypertension, and the related risk factors in a Korean population. A cross-sectional study was conducted in a rural area of South Korea from 2005 to 2006. Subjects (n = 6388) were selected from individuals aged 40 years or older by stratified random cluster sampling. The age-adjusted prevalence of hypertension was 43.8 % (43.1 % in men, 44.9 % in women). The awareness, treatment, and control of hypertension were 60.1%, 91.7%, and 27.2%, respectively. In men, old age (>/= 60 years old) and low waist circumference (< 90 cm) were positively associated with higher awareness and treatment, whereas body mass index (BMI) was negatively associated with blood pressure (BP) control. Women aged 60 years or older were more aware of their condition, more treated, and more in control of their BP as well. In women, high BMI and a family history of diabetes mellitus were positively associated with higher awareness and treatment, whereas low waist circumference (< 80 cm) was negatively associated with BP control. Our findings indicate that appropriate health care should be given to hypertensive subjects on the basis of these risk factors and according to their sex.</P>
Seol, Hyun-Joo,Oh, Min-Jeong,Yeo, Min-Koo,Kim, Aeree,Lee, Eung-Seok,Kim, Hai-Joong Marcel Dekker, Inc 2010 Hypertension in pregnancy Vol.29 No.3
<P>Objective. The aim of this study was to evaluate serum resistin levels in women with preeclampsia compared to those in normal pregnant women and normal non-pregnant women, and to examine placental resistin expression. Methods. Serum resistin levels were measured by enzyme-linked immunosorbent assay and placental resistin expression was determined by immunohistochemistry. Results. Serum resistin levels were significantly elevated in women with preeclampsia compared to normal pregnant women and non-pregnant women. There was no significant difference in placental resistin expression. Conclusion. The placenta may not be the origin of the resistin that contributes to increased serum levels in women with preeclampsia.</P>
Lee, Bomi,Trinh, Hien Trung,Jung, Kangsik,Han, Sang-Jun,Kim, Dong-Hyun Marcel Dekker 2010 IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY Vol.32 No.3
<P>To investigate the antiallergic effect of the rhizome of Anemarrhena asphodeloides (AA, family Liliaceae), which was found to inhibit the mouse passive cutaneous anaphylaxis (PCA) reaction induced by the antigen-immunoglobulin E (IgE) complex in preliminary experiments, main steroidal saponins, timosaponins AIII, BIII, and D, were isolated and their inhibitory effects against PCA reaction and scratching behaviors investigated in mice. Oral administration of three main steroidal sapogenins blocked the PCA reaction and scratching behaviors, timosaponin AIII was the most potent. However, intraperitoneal administration of timosaponin AIII showed weak inhibition. To understand its metabolism and antiallergic mechanism, timosaponin AIII was anaerobically incubated with human intestinal microflora to afford a main metabolite, sarsasapogenin. Intraperitoneal administration of sarsasapogenin inhibited allergic reaction more potently than timosaponin AIII. In addition, sarsasapogenin more potently inhibited degranulation and IL-4 protein expression of RBL-2H3 cells induced by IgE-antigen complex than timosaponin AIII. On the basis of these findings, antiallergic effect of AA may be due to those of its steroidal constituents, and that of timosaponin AIII may be activated by using intestinal microflora.</P>
Choi, Hye-Min,Veriansyah, Bambang,Kim, Jaehoon,Kim, Jae-Duck,Lee, Youn-Woo Marcel Dekker 2009 Journal of Environmental Science and Health. Part Vol.44 No.5
<P>Catalytic hydrodechlorination of polychlorinated biphenyls (PCBs) in the presence of transformer oil was carried out in a batch mode to detoxify PCBs and to recycle the treated oil. Various metal supported catalysts, including 0.98 wt% Pt, 0.79 wt% Pd and 12.8 wt% Ni on gamma -alumina (gamma -Al(2)O(3)) support, and 57.6 wt% Ni on silicon oxide-aluminum oxide (SiO(2)-Al(2)O(3)) support were used for the hydrodechlorination. Metal particle size of the Pt catalyst was 2.0 nm and metal particle sizes of the Pd and Ni catalysts were in the range of 6.4-6.9 nm. Various supercritical fluids, supercritical carbon dioxide (scCO(2)), supercritical propane (scPropane), supercritical dimethyl ether (scDME) and supercritical isobutane (scIsobutane) were used as reaction media. PCBs conversion, dechlorination degree of PCBs, was measured using gas chromatograph (GC) with an electron capture detector (ECD). The hydrodechorination degree increased in the order Ni > Pd > Pt, possibly due to higher metal loading and larger metal size of the Ni catalysts. At temperatures below 175 degrees C, scCO(2) was effective as the reaction media for the catalytic hydrodechlorination of PCBs in the presence of the transformer oil. However, PCBs conversion decreased significantly when the hydrodechlorination was carried out in a homogeneous phase with using scPropane, scDME or scIsobutane as a reaction medium. This was attributed to dilution effect of the supercritical fluids. Molecular weights of the transformer oils before and after the catalytic hydrodechlorination were analyzed using high-performance size exclusion chromatography (HPSEC). The molecular weight of the treated oil with 100 % PCBs conversion did not change after the catalytic hydrodechlorination at 200 degrees C. This process has proven to be effective to detoxify PCBs containing transformer oil and to recycle the treated oil.</P>
Toxic effects of mercuric sulfide on immune organs in mice.
Son, Hee-Young,Lee, Soyoung,Park, Seung-Bin,Kim, Mi-Sun,Choi, Eun-Ju,Singh, Thoudam S K,Bae, Yunju,Kwack, Seung Jun,Kang, Tae Seok,Shin, Hong-In,Baek, Moon-Chang,Kim, Sang-Hyun Marcel Dekker 2010 IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY Vol.32 No.2
<P>Mercuric sulfide (HgS) is a major component of cinnabar, which has been used as a sedative drug in China for more than 2000 years. Because its toxicological effects are still unclear, we attempted to verify the toxic effects of HgS, focused on liver and immune organs such as the spleen and thymus. Male ICR mice were administered HgS (0.02, 0.2, 2.0 g/kg/day) by gavage for 4 weeks. During the administration period, HgS-treated mice did not reveal overt signs of clinical toxicity. HgS had no significant effect on body weight, food consumption, water consumption, and organ weights. In spite of its known insolubility, HgS was absorbed by the gastrointestinal tract and accumulated in the liver, spleen and thymus in a dose-dependent manner. In the biochemical and histological examination, HgS did not cause hepatotoxicity. However, HgS significantly increased both CD8(+) T lymphocytes and CD4(+)CD8(+) lymphocyte populations in the spleen without changing in the thymus. In the histological evaluation, HgS induced enlargement with marked hyperplasia and increase of lymphoid follicles in the spleen. In addition, HgS induced the gene expression of pro-inflammatory cytokines in the spleen and thymus. Our results suggest that insoluble HgS was absorbed by the gastrointestinal tract, accumulated in the spleen and thymus, and thus could affect immune systems.</P>
Cho, Min-Chul,Lee, Sojung,Choi, Hee-Sook,Yang, Young,Tae Hong, Jin,Kim, Sun-Jong,Yoon, Do-Young Marcel Dekker 2009 IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY Vol.31 No.3
<P>Peroxisome proliferator-activated receptors (PPARs) are transcription factor which directly modulate gene expression by binding to specific agonists. It has been reported that PPARalpha controls lipid metabolism, inflammation, and atherosclerosis. PPARalpha activation by PPARalpha agonist can ultimately reduce the progression of atherosclerosis and decrease the incidence of coronary heart disease. In this study, we optimized enzyme-linked immunosorbent assay (ELISA) systems in order to screen putative PPARalpha agonists. These methods are based on the activation mechanism of PPARalpha where the ligand binding to PPARalpha induces the interaction of the receptor with transcriptional co-activators. Among co-activators such as SRC-1, TIF-2, and p300, although ligand-unbound PPARalpha had more strong binding with p300 at a lower concentrations of PPARalpha, ligand-bound PPARalpha had more specific and strong binding with SRC-1. We optimized and developed a novel and useful ELISA system to screen PPARalpha agonists. Wy14,643 and linoleic acid, the well-known PPARalpha ligands, increased the binding between PPARalpha and co-activators in a ligand dose-dependent manner. In this ELISA method to screen PPARalpha ligands, the use of specific anti-PPARalpha N-terminus antibody, full-length recombinant protein of human PPARalpha but not ligand-binding domain (LBD) of human PPARalpha, and his-tagged PPARalpha recombinant proteins but not GST-fused PPARalpha recombinant proteins is the critical factors. Development of this screening system may be useful in the discovery of PPARalpha ligands from various candidates such as chemical library and phytochemicals.</P>