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Kim, Seong-Jang,Song, Sang Heon,Kim, Ji Hoon,Kwak, Ihm Soo Japanese Society of Nuclear Medicine 2008 Annals of nuclear medicine Vol.22 No.3
Objective The aim of this study is to investigate the relationship between regional cerebral blood flow (rCBF) and symptom clusters of depressive mood in pre-dialytic chronic kidney disease (CKD). Methods Twenty-seven patients with stage 4?5 CKD were subjected to statistical parametric mapping analysis of brain single-photon emission computed tomography. Correlation analyses between separate symptom clusters of depressive mood and rCBF were done. Results The first factor (depressive mood) was negatively correlated with rCBF in the right insula, posterior cingulate gyrus, and left superior temporal gyrus, and positively correlated with rCBF in the left fusiform gyrus. The second factor (insomnia) was negatively correlated with rCBF in the right middle frontal gyrus, bilateral cingulate gyri, right insula, right putamen, and right inferior parietal lobule, and positively correlated with rCBF in left fusiform gyrus and bilateral cerebellar tonsils. The third factor (anxiety and psychomotor aspects) was negatively correlated with rCBF in the left inferior frontal gyrus, right superior frontal gyrus, right middle temporal gyrus, right superior temporal gyrus, and left superior frontal gyrus, and positively correlated with rCBF in the right ligual gyrus and right parahippocampal gyrus. Conclusions In this study, the separate symptom clusters were correlated with specific rCBF patterns similar to those in major depressive disorder patients without CKD. However, some areas with discordant rCBF patterns were also noted when compared with major depressive disorder patients. Further larger scale investigations are needed.
MIN, Jung-Joon,AHN, Youngkeun,MOON, Sungmin,Sook KIM, Yong,Eun PARK, Jong,Mi KIM, Sung,N. LE, Uyenchi,C. WU, Joseph,Yeon JOO, Soo,Hwa HONG, Moon,Hwan YANG, Deok,Ho JEONG, Myung,Hun SONG, Chang,Hyeok J Japanese Society of Nuclear Medicine 2006 Annals of nuclear medicine Vol.20 No.3
<P>Objective: The conventional method for the analysis of myocardial cell transplantation depends on postmortem histology. Here, we have sought to demonstrate the feasibility of a longitudinal monitoring of transplanted cell survival in living animals, accomplished with optical imaging techniques and pharmacological interventions. Methods: Human cord blood (50 ml) was donated with parental consent. After getting cord blood derived mesenchymal stem cells (CBMSCs), cellswere transfected (MOI = 100) overnight with adenovirus encoding firefly luciferase gene (Ad- CMV-Fluc). Our experimental Sprague-Dawley rats (n = 12) were given intramyocardial injections containing 1 × <TEX>$10^6$</TEX> CBMSCs, which had been made to express the firefly luciferase (Fluc) reporter gene. Optical bioluminescence imaging was then conducted using a cooled charged-coupled device (CCD) camera (Xenogen), beginning on the day after the transplantation (day 1). Groups of mice were intraperitoneally injected with cyclosporine (5 mg/kg) or tacrolimus (1 mg/kg), in an attempt to determine the degree to which cell survival had been prolonged, and these values were then compared with the cell survival values of the negative control group. The presence of transplantedCBMSCs on in vivo images confirmed by in situ hybridization for human specific Alu in the myocardium. Results: Cardiac bioluminescence signals were determined to be present for 6 days after transplantation: day 1 (97000 ± 9100 × 105 p/s/㎠/sr), day 3 (9600 ± 1110 p/s/㎠/sr), and day 5 (3200 ± 550 p/s/㎠/sr). The six mice that received either cyclosporine or tacrolimus displayed cardiac bioluminescence signals for a period of 8 days after transplantation. We observed significant differences between the treated group and the non-treated group, beginning on day 3 (tacrolimus;26500 ± 4340 p/s/㎠/sr, cyclosporine;27200 ± 3340 p/s/㎠/sr, non-treated;9630 ± 1180 p/s/㎠/sr, p < 0.01), and persisting until day 7 (tacrolimus;12500 ± 2946 p/s/㎠/sr, cyclosporine;7310 ± 1258 p/s/㎠/sr, non-treated;2460 ± 160 p/s/㎠/sr, p < 0.01). The humanderived CBMSCs were detected in the myocardium 3 days after transplantation by in situ hybridization. Conclusions: The locations, magnitude, and survival duration of the CBMSCs were noninvasively monitored with a bioluminescence optical imaging system. We determined that optical molecular imaging expedites the fast throughput screening of pharmaceutical agents, allowing for the noninvasive tracking of cell survival within animals. In rat cardiac CBMSC transplant models, transient immunosuppressive treatment with tacrolimus or yclosporine was shown to improve donor cell survival."</P>
Ahn, Sung Jun,Park, Mi-Suk,Lee, Jong Doo,Kang, Won Jun Japanese Society of Nuclear Medicine 2014 Annals of nuclear medicine Vol.28 No.5
<P>The histopathological grade of differentiation is one of the significant prognostic factors in pancreatic adenocarcinoma. Especially in the patients with unresectable pancreatic cancer, it is important to obtain the prognostic information non-invasively to avoid unnecessary invasive procedure. The aim of the study was to correlate (18)F-fluorodeoxyglucose (FDG) uptake with pathologic grade of pancreatic cancer, furthermore, to evaluate prognostic value of standardized uptake value (SUV).</P>
Pharmacokinetics and biodistribution of a small radioiodine labeled nerve growth factor fragment
JUNG, Kyung-Ho,KIM, Dong-Hyun,PAIK, Jin-Yung,KO, Bong-Ho,BAE, Jun-Sang,Seong CHOE, Yearn,LEE, Kyung-Han,KIM, Byung-Tae Japanese Society of Nuclear Medicine 2006 Annals of nuclear medicine Vol.20 No.8
<P>Nerve growth factor (NGF) exerts various actions on neuronal and non-neuronal tissues and has potential therapeutic utility, but difficulties in using the whole protein have stimulated interest in small NGF fragments. We radioiodinated a small cyclic peptide derived from NGF using the Bolton-Hunter method [<TEX>$^{125}I$</TEX>-C(92-96)], and confirmed binding to high affinity NGF receptors by cross-linkage analysis. Pharmacokinetic characteristics in intravenously injected mice were T1/2α 5.2 min, T1/2β 121.3 min, clearance 11.8 ± 0.5 ml/min, and volume of distribution 69.7 ± 4.6 ml. Dose-proportionate increases in areas-under-curve and peak-concentrations indicated linear pharmacokinetics. Biodistribution data revealed that clinically relevant doses allowed C(92-96) accumulation sufficient to elicit biological responses in receptor expressing organs including the lungs, liver, spleen, and pancreas.</P>
Jun, Sungmin,Lee, Jong Jin,Park, Seol Hoon,Kim, Tae Yong,Kim, Won Bae,Shong, Young Kee,Ryu, Jin-Sook Japanese Society of Nuclear Medicine 2015 Annals of nuclear medicine Vol.29 No.7
<P>Objective A diffuse hepatic uptake (DHU) on radioiodine whole-body scans (WBS) after I-131 therapy is caused by I-131-labeled iodoproteins, particularly I-131-labeled thyroglobulin (Tg). We hypothesized that the DHU intensity after I-131 therapy might correlate with subsequent serum Tg reduction, suggesting that DHU reflects destruction of functioning thyroid tissue as measured by serum Tg. Materials and Methods We retrospectively reviewed the medical records and I-131 WBSs of 47 patients treated with I-131 therapy for distant metastasis from differentiated thyroid cancer (M:F = 15:32, median age 45 years, range 11-74 years). All patients received post-ablative I-131 scans (PAWBS) at first I-131 ablation after total thyroidectomy and post-therapy I-131 scan (PTWBS) at second I-131 therapy. The DHU intensities of the PAWBS and PTWBS were classified into 3 grades: 1, faint; 2, modest; and 3, intense. Serum thyroid-stimulating hormone-stimulated Tg (sTg) levels were measured at the time of each therapy and 1 year after the second I-131 therapy. Results One year after the second I-131 therapy, 10 patients (21.3 %) were in remission and 37 (78.7 %) had persistent disease. The DHU intensity on PAWBS correlated with the percentage sTg reduction at the next follow-up point (sigma = 0.466, p = 0.0016). The patients with intense DHU on PTWBS tended to have a higher percentage sTg reduction than the other patients, although statistical significances were marginal (Spearman's rank correlation: sigma = 0.304, p = 0.054; Kruskal-Wallis test: p = 0.067). In univariate analysis, the DHU grades on PAWBS and the initial sTg levels were significantly different between patients in remission and those with persistent disease (PAWBS: p = 0.022; initial sTg: p = 0.0059). In multivariate logistic regression analysis, after adjusting for initial sTg levels, a DHU grade of 3 on PAWBS was an independent predictor of remission (PAWBS: p = 0.028; initial sTg < 100 ng/ml: p = 0.043). Conclusions In patients with iodine-avid distant metastases, intensity of DHU on I-131 post-therapy scan correlated with subsequent percentage serum sTg reduction. Also, intense DHU could be one of the predictors of remission in these patients.</P>
Kim, Dae-Weung,Kim, Woo Hyoung,Kim, Myoung Hyoun,Kim, Chang Guhn,Oh, Chang-Sok,Min, Jung-Joon Japanese Society of Nuclear Medicine 2014 Annals of nuclear medicine Vol.28 No.5
<P>Glutathione (GSH) plays a critical role in detoxification reactions by reducing the levels of reactive oxygen species in cancer cells. This study aimed to develop technetium (Tc)-99m diethylenetriaminepentaacetic acid (DTPA)-GSH as a tumor imaging agent, and to evaluate the diagnostic performance of Tc-99m DTPA-GSH in terms of its ability to differentiate tumors from inflammatory lesions.</P>
Yoon, Hai-Jeon,Kim, Yemi,Chang, Kyu-Tae,Kim, Bom Sahn Japanese Society of Nuclear Medicine 2015 Annals of nuclear medicine Vol.29 No.7
<P>This study investigated the prognostic value of preoperative breast-specific gamma imaging (BSGI) uptake measured by a semi-quantitative method in invasive ductal carcinoma (IDC).</P>
Pak, Kyoungjune,Park, Sohyun,Cheon, Gi Jeong,Kang, Keon Wook,Kim, In-Joo,Lee, Dong Soo,Kim, E Edmund,Chung, June-Key Japanese Society of Nuclear Medicine 2015 Annals of nuclear medicine Vol.29 No.5
<P>Nowadays, the number of primary studies on fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) has been increasing rapidly. Thus, we updated meta-analysis to evaluate the test performance of FDG PET/CT for nodal staging in non-small cell lung cancer (NSCLC) including the most recent studies.</P>
Byun, Byung Hyun,Na, Im Il,Cheon, Gi Jeong,Kang, Hye Jin,Kim, Kyeong Min,Lee, Seung-Sook,Ryoo, Baek-Yeol,Choi, Chang Woon,Lim, Sang Moo,Yang, Sung Hyun Japanese Society of Nuclear Medicine 2008 Annals of nuclear medicine Vol.22 No.8
Objective This pilot study was launched to explore the utility of positron emission tomography scans, at the time of diagnosis, for clinical outcomes in patients with primary extranodal non-Hodgkin’s lymphoma (PENHL) in the head and neck, retrospectively. Methods Twenty-two patients with a diffuse large B cell lymphoma (DLBCL) among those with a PENHL were included. We retrospectively evaluated the clinical outcomes of patients according to the maximum standardized <SUP>18</SUP>F-fluoro-2-deoxy-glucose (<SUP>18</SUP>F-FDG) uptake value of the primary lesion (SUVp). The SUVp was initially analyzed as a continuous variable. The cut-offvalue of SUVp was obtained from receiver-operating characteristic analysis to predict event-free survival. Using this value, patients were divided into those with a low and high SUV. Results Seventeen patients (59%) were men and the median age was 50 years. Most primary sites were in Waldeyer’s ring (73%). The SUVp ranged from 3.3 to 23.7. The international prognostic index (IPI < 2 vs. ≥ 2) was associated with the SUVp (P = 0.014). Patients with low SUVp showed favorable survival (P = 0.015). After IPI scores were stratified, the survival difference remained significant (P = 0.029). Conclusions The results of this pilot investigation indicate that <SUP>18</SUP>F-FDG uptake of the primary lesion may be related with survival outcomes in patients with extranodal DLBCL in the head and neck. Further studies are needed to confirm and extend these results.