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RISS 인기검색어
- 검색키워드
- 발행기관 : Faculdade de Odontologia de Bauru da Universidade (검색결과 3 건)
- 무료
- 기관 내 무료
- 유료
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Validating of the pre-clinical mouse model for metastatic breast cancer to the mandible
HWANG, Young Sun,HAN, Sang-Sun,KIM, Ki-Rim,Ye-Jin, LEE,Sun-Kyung, LEE,Kwang-Kyun, PARK,Won-Yoon, CHUNG Faculdade de Odontologia de Bauru da Universidade 2015 Journal of applied oral science Vol.23 No.1
<P>Metastatic breast carcinoma has a great tendency to spread to the mandible. It is concomitantly associated with bone destruction, food intake disorder, and a poorer prognosis. Appropriate animal models need to be developed for a better understanding of the mechanisms underlying the metastatic process of breast cancer cells to mandible and to test the effects of potential lead compounds. Here, we assessed the metastasis model of intracardiac injection using luciferase-transfected metastatic breast cancer cells (MDA-MB-231<SUP>Luc+</SUP>) by determining the incidences of metastasis, mCT images, and histopathological results. A high bioluminescence signal mainly detected mandibular lesions with less frequent distal femora and proximal tibiae lesions. Extensive mandibular bone destruction occurred in nude mice grafted with metastatic breast cancer cells. This type of animal model might be a useful tool in assessing therapeutic implications and the efficacy of anti-cancer drugs for osteolytic cancers.</P>
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Dong-Ae, KIM,Hany, ABO-MOSALLAM,Hye-Young, LEE,Jung-Hwan, LEE,Hae-Won, KIM,Hae-Hyoung, LEE Faculdade de Odontologia de Bauru da Universidade 2015 Journal of applied oral science Vol.23 No.4
<P>Some weaknesses of conventional glass ionomer cement (GIC) as dental materials, for instance the lack of bioactive potential and poor mechanical properties, remain unsolved. </P><P><B>Objective</B></P><P> The purpose of this study was to investigate the effects of the partial replacement of CaO with MgO or ZnO on the mechanical and biological properties of the experimental glass ionomer cements.</P><P><B>Material and Methods</B></P><P> Calcium fluoro-alumino-silicate glass was prepared for an experimental glass ionomer cement by melt quenching technique. The glass composition was modified by partial replacement (10 mol%) of CaO with MgO or ZnO. Net setting time, compressive and flexural properties, and <I>in vitro </I>rat dental pulp stem cells (rDPSCs) viability were examined for the prepared GICs and compared to a commercial GIC.</P><P><B>Results</B></P><P> The experimental GICs set more slowly than the commercial product, but their extended setting times are still within the maximum limit (8 min) specified in ISO 9917-1. Compressive strength of the experimental GIC was not increased by the partial substitution of CaO with either MgO or ZnO, but was comparable to the commercial control. For flexural properties, although there was no significance between the base and the modified glass, all prepared GICs marked a statistically higher flexural strength (p<0.05) and comparable modulus to control. The modified cements showed increased cell viability for rDPSCs.</P><P><B>Conclusions</B></P><P> The experimental GICs modified with MgO or ZnO can be considered bioactive dental materials.</P>
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Differential expression of immunologic proteins in gingiva after socket preservation in mini pigs
JUNG, Seunggon,YANG, Hee-Young,LEE, Tae-Hoon Faculdade de Odontologia de Bauru da Universidade 2015 Journal of applied oral science Vol.23 No.2
<P>During healing following tooth extraction, inflammation and the immune response within the extraction socket are related to bone resorption. </P><P><B>Objective</B></P><P>: We sought to identify how the alloplastic material used for socket preservation affects the immune responses and osteoclastic activity within extraction sockets.</P><P><B>Material and Methods</B></P><P> : Using a porcine model, we extracted teeth and grafted biphasic calcium phosphate into the extraction sockets. We then performed a peptide analysis with samples of gingival tissue from adjacent to the sockets and compared the extraction only (EO) and extraction with socket preservation (SP) groups. We also used real-time polymerase chain reaction (PCR) to evaluate the expression level of immunoglobulins, chemokines and other factors related to osteoclastogenesis. Differences between the groups were analyzed for statistical significance using paired t tests.</P><P><B>Results</B></P><P> : Levels of IgM, IgG and IGL expression were higher in the EO group than in the SP group 1 week post-extraction, as were the levels of CCL3, CCL5, CXCL2, IFN-γ and TNF-α expression (p<0.05). In addition, receptor activator of nuclear factor kappa-B ligand (RANKL) was also significantly upregulated in the EO group (p<0.05), as were IL-1β, IL-6 and IL-8 (p<0.05).</P><P><B>Conclusions</B></P><P> : These results suggest that the beneficial effect of socket preservation can be explained by suppression of immune responses and inflammation.</P>
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