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      • Prostatic urethral length as a predictive factor for surgical treatment of benign prostatic hyperplasia: a prospective, multiinstitutional study

        Kim, Bum Soo,Ko, Young Hwii,Song, Phil Hyun,Kim, Tae-Hwan,Kim, Ki Ho,Kim, Byung Hoon Asian Pacific Prostate Society 2019 Prostate international Vol.7 No.1

        <P><B>Background</B></P><P>We hypothesized that prostatic anatomical factors may affect the progression of benign prostatic hyperplasia (BPH) and analyzed whether prostatic anatomical factors could be predictive of the risk of surgery.</P><P><B>Materials and methods</B></P><P>From February to October 2014, 679 men older than 40 years who had lower urinary tract symptoms and enlarged prostates were enrolled from five medical centers. Patients' medical characteristics, serum prostate-specific antigen levels, transrectal ultrasound (TRUS) results, and uroflowmetry were analyzed. Using TRUS in all patients, the total prostate volume, transitional zone volume, prostatic urethral length, transitional zone urethral length, intravesical prostatic protrusion, and prostatic urethral angle were measured. Logistic regression analysis was used to determine factors associated with the risk of surgery. Receiver operating characteristic curves were used to determine cutoff values for significant variables.</P><P><B>Results</B></P><P>Of 679 patients, 37 (5.4%) underwent BPH-related surgery. Prostatic urethral length and transitional zone urethral length were independently associated with the risk of surgery. Age, serum prostate-specific antigen levels, peak flow rate, postvoid residual urine, and other anatomical factors determined by TRUS were not statistically significant with respect to the risk of surgery. Using receiver operating characteristic curve–based predictions, the best cutoff values for prostatic and transitional zone urethral length were 4.53 cm (sensitivity: 83.3%, specificity: 61.6%) and 3.35 cm (sensitivity: 83.3%, specificity: 77.9%), respectively.</P><P><B>Conclusions</B></P><P>This study showed that patients with BPH with longer prostatic and transitional zone urethral lengths had a higher risk of surgery. Prostatic and transitional zone urethral length may be useful predictive factors for medical treatment failure in patients with BPH.</P>

      • Asia prostate cancer study (A-CaP Study) launch symposium

        Akaza, Hideyuki,Hirao, Yoshihiko,Kim, Choung-Soo,Oya, Mototsugu,Ozono, Seiichiro,Ye, Dingwei,Cooperberg, Matthew,Hinotsu, Shiro,Lee, Ji Youl,Zhu, Gang,Namiki, Mikio,Horie, Shigeo,Chung, Byung Ha,Chen, Asian Pacific Prostate Society 2016 Prostate international Vol.4 No.3

        <P>The Asian Prostate Cancer (A-CaP) Study is an Asia-wide initiative that has been developed over the course of 2 years. The A-CaP Study is scheduled to begin in 2016, when each participating country or region will begin registration of newly diagnosed prostate cancer patients and conduct prognosis investigations. From the data gathered, common research themes will be identified, such as comparisons among Asian countries of background factors in newly diagnosed prostate cancer patients. This is the first Asia-wide study of prostate cancer and has developed from single country research efforts in this field, including in Japan and Korea. The inaugural Board Meeting of A-CaP was held on December 11, 2015 at the Research Center for Advanced Science and Technology, The University of Tokyo, attended by representatives of all participating countries and regions, who signed a memorandum of understanding concerning registration for A-CaP. Following the Board Meeting an A-CaP Launch Symposium was held. The symposium was attended by representatives of countries and regions participating in A-CaP, who gave presentations. Presentations and a keynote address were also delivered by representatives of the University of California San Francisco, USA, and the Peter MacCallum Cancer Centre, Australia, who provided insight and experience on similar databases compiled in their respective countries.</P>

      • Report of the Second Asian Prostate Cancer (A-CaP) Study Meeting

        Kim, Choung-Soo,Lee, Ji Youl,Chung, Byung Ha,Kim, Wun-Jae,Fai, Ng Chi,Hakim, Lukman,Umbas, Rainy,Ong, Teng Aik,Lim, Jasmine,Letran, Jason L.,Chiong, Edmund,Wu, Tong-lin,Lojanapiwat, Bannakij,,rk Asian Pacific Prostate Society 2017 Prostate international Vol.5 No.3

        <P>The Asian Prostate Cancer (A-CaP) Study is an Asia-wide initiative that has been developed over the course of 2 years. The study was launched in December 2015 in Tokyo, Japan, and the participating countries and regions engaged in preparations for the study during the course of 2016, including patient registration and creation of databases for the purpose of the study. The Second A-CaP Meeting was held on September 8, 2016 in Seoul, Korea, with the participation of members and collaborators from 12 countries and regions. Under the study, each participating country or region will begin registration of newly diagnosed prostate cancer patients and conduct prognostic investigations. From the data gathered, common research themes will be identified, such as comparisons among Asian countries of background factors in newly diagnosed prostate cancer patients. This is the first Asia-wide study of prostate cancer and has developed from single country research efforts in this field, including in Japan and Korea. At the Second Meeting, participating countries and regions discussed the status of preparations and discussed various issues that are being faced. These issues include technical challenges in creating databases, promoting participation in each country or region, clarifying issues relating to data input, addressing institutional issues such as institutional review board requirements, and the need for dedicated data managers. The meeting was positioned as an opportunity to share information and address outstanding issues prior to the initiation of the study. In addition to A-CaP-specific discussions, a series of special lectures was also delivered as a means of providing international perspectives on the latest developments in prostate cancer and the use of databases and registration studies around the world.</P>

      • Development of prostate cancer research database with the clinical data warehouse technology for direct linkage with electronic medical record system

        Choi, In Young,Park, Seungho,Park, Bumjoon,Chung, Byung Ha,Kim, Choung-Soo,Lee, Hyun Moo,Byun, Seok-Soo,Lee, Ji Youl Asian Pacific Prostate Society (APPS) 2013 Prostate international Vol.1 No.2

        <P><B>Purpose:</B></P><P>In spite of increased prostate cancer patients, little is known about the impact of treatments for prostate cancer patients and outcome of different treatments based on nationwide data. In order to obtain more comprehensive information for Korean prostate cancer patients, many professionals urged to have national system to monitor the quality of prostate cancer care. To gain its objective, the prostate cancer database system was planned and cautiously accommodated different views from various professions.</P><P><B>Methods:</B></P><P>This prostate cancer research database system incorporates information about a prostate cancer research including demographics, medical history, operation information, laboratory, and quality of life surveys. And, this system includes three different ways of clinical data collection to produce a comprehensive data base; direct data extraction from electronic medical record (EMR) system, manual data entry after linking EMR documents like magnetic resonance imaging findings and paper-based data collection for survey from patients.</P><P><B>Results:</B></P><P>We implemented clinical data warehouse technology to test direct EMR link method with St. Mary’s Hospital system. Using this method, total number of eligible patients were 2,300 from 1997 until 2012. Among them, 538 patients conducted surgery and others have different treatments.</P><P><B>Conclusions:</B></P><P>Our database system could provide the infrastructure for collecting error free data to support various retrospective and prospective studies.</P>

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