소셜미디어에서 관찰되는 Helicobacter pylori에 대한 정보의 특성 및 전달방식 분석

방창석,백광호 대한상부위장관ㆍ헬리코박터학회 2016 Korean Journal of Helicobacter Upper Gastrointesti Vol.16 No.4

Background/Aims: Current production of knowledge and distribution of data is frequently mediated by social media in the form of unstructured text data rather than classical newspaper or journal format. Management of Helicobacter pylori infection is an important issue in Korea. However, there has been no study on the characteristics of information regarding H. pylori consumed and distributed in the social media by general population. Materials and Methods: This study evaluated characteristics of social media data regarding H. pylori in Korea using semantic network analysis with Textom and NodeXL Pro (2015.8.11∼2016.8.11, Naver, Daum, Youtube, and Twitter searching). Results: Total collected data in the Textom analysis about '헬리코박터' was 10,061. TF-IDF (term frequency × inverse document frequency) was as follows: ‘위암’, ‘위’, ‘감염’, ‘윌’, ‘균’, ‘치료’, ‘위궤양’, ‘원인’, ‘프로젝트’, ‘음식’, ‘세균’, ‘검사’, ‘예방’, ‘증상’, ‘건강’, ‘약’, ‘효과’. In the Twitter analysis, 96 nodes and 120 edges, and 86 unique edges were detected, suggesting low distribution of data. Misinformed data such as ‘헬리코박터-파이로리’, ‘라는-바이러스때문에’, ‘헬리코박터-프로젝트’, ‘위궤양이나-위’, ‘점막-출혈을’, ‘비 롯하여-각종’, ‘부종을-억제하고’, ‘치료하는데-효과가’, ‘있습니다-또한’, ‘장티푸스-이질’, ‘등-전염성’, ‘세균이나-장’, ‘속의-세균 을’, ‘억제하는-효과가’, ‘프로젝트-윌’ were found. The most viewed movie in the Youtube analysis was ‘한국야쿠르트 헬리코박터 프로젝 트 윌 그 한입을 경계하라_15초’ (210,577). Conclusions: Relative insufficiency, low distribution, and some misinformed data were found in some part of social media. Participation of healthcare professional is warranted to solve these issues

무증상 환자에서 상부위장관 내시경으로 우연히 발견된 바터팽대부의 소세포 신경내분비암종 1예

주종석,김주석,신해진,김기대,문희석,강선형,성재규,정현용,김경희,송인상 대한상부위장관ㆍ헬리코박터학회 2015 Korean Journal of Helicobacter Upper Gastrointesti Vol.15 No.3

바터팽대부의 소세포 신경내분비암종은 매우 드문 질환으로 국내에서는 3예가 보고되었다. 이전에 보고된 3예의 경우 황달이나 복통으로 내원하여 내시경적 역행성 담췌관 조영술을 통한 조직검사로 소세포 신경내분비암종이 확진되어 수술적 치료를 시행하였다. 최근 저자들은 무증상 환자에서 검진 목적으로 시행한 상부위장관 내시경에서 바터팽대부의 궤양성 병변이 관찰되어 시행한 조직검사에서 소세포 신경내분비암종으로 진단된 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Small cell neuroendocrine carcinoma in the ampulla of Vater is a rare disease and there have only been three cases reported in Korea. In these three cases, the patients had symptoms of abdominal pain and jaundice. A biopsy via endoscopic retrograde cholangiopancreatography confirmed a small cell neuroendocrine carcinoma; thus, each patient underwent surgical treatment. Recently, we experienced a case of small cell neuroendocrine carcinoma in an asymptomatic patient. An ulcerative lesion was identified during screening gastroduodenoscopy. Here, we report this case and review the relevant literature.

헬리코박터 파일로리 제균 치료와 위암 예방

박찬혁 대한상부위장관ㆍ헬리코박터학회 2021 Korean Journal of Helicobacter Upper Gastrointesti Vol.21 No.4

Since Warren and Marshall demonstrated Helicobacter pylori (H. pylori) as a cause of gastritis in the early 1980s, H. pylori has been associated with various gastric diseases, including gastric ulcer, gastric mucosa-associated lymphoid tissue (MALT) lymphoma, gastric adenoma, gastric adenocarcinoma, and hyperplastic gastric polyps. H. pylori eradication therapy can treat some associated diseases, including low-grade gastric MALT lymphoma, and significantly reduce the risk of peptic ulcer recurrence or progression of atrophic gastritis and intestinal metaplasia. In East Asia, where H. pylori and gastric cancer are prevalent, several studies have been conducted to prove whether the risk of gastric cancer development is reduced through H. pylori eradication therapy. Early studies failed to show the benefits of H. pylori eradication therapy in gastric cancer prevention. However, recent studies with extended follow-up periods have reported reduced risks of gastric cancer after treatment of H. pylori infection. H. pylori eradication therapy effectively prevents gastric cancer even in patients who were treated for early gastric cancer, and can be used in treating hyperplastic gastric polyps. Herein, we reviewed current evidence supporting the benefits of H. pylori eradication therapy to help clinicians understand its impact on gastric cancer prevention and hyperplastic polyp treatment.

헬리코박터의 제균 치료 후 과증식 위용종 환자에서 용종의 크기 변화: 전향적 연구

유아영,박종재,주문경,이범재,전훈재,이상우 대한상부위장관ㆍ헬리코박터학회 2019 Korean Journal of Helicobacter Upper Gastrointesti Vol.19 No.4

Background/Aims: Helicobacter pylori (H. pylori) eradication is known to be effective for reducing the size of gastric hyperplastic polyps (HPPs). This study investigated the change in size of gastric HPPs after H. pylori eradication. Materials and Methods: This was a prospective study that enrolled 25 H. pylori-positive patients diagnosed as having HPPs at Korea University Guro Hospital between July 2015 and July 2016. If the patient wanted to receive eradication therapy, medication was given. If the patients refused eradication, only clinical follow-up was performed. All patients were subsequently followed up with endoscopic examination to determine any change in polyp size. Results: Eighteen of the 25 H. pylori-positive patients diagnosed as having HPPs were given an eradication regimen, and 17 were confirmed to have achieved successful eradication. Twelve (70.8%) of the 17 patients in the eradication group showed ≥50% reduction in size, while two (25.0%) of the eight patients in the non-eradication group showed 50% reduction. The polyp regression rate was significantly higher in the eradication group (P=0.03). A multivariate analysis revealed that H. pylori eradication (OR, 40.047; 95% CI, 1.112~1442.767; P=0.044) and female sex (OR, 12.947; 95% CI, 1.038~161.503; P=0.047) were significant predictive factors of HPP regression. Conclusions: H. pylori eradication is an effective therapeutic modality for gastric HPP regression.

한국인에서 흔한 위 상피하 종양들

유대곤,최철웅 대한상부위장관ㆍ헬리코박터학회 2022 Korean Journal of Helicobacter Upper Gastrointesti Vol.22 No.1

Gastric subepithelial tumors (SETs) are often discovered incidentally and are usually benign. Their subepithelial location complicates accurate diagnosis; however, most lesions can be differentiated using either endoscopy or endoscopic ultrasonography. Gastric SETs location, color, surface change, size, consistency, and movability are evaluated during endoscopy. Endoscopic ultrasound assesses their originating layer, echogenicity, and homogeneity. Common gastric SETs in Koreans include ectopic pancreas, lipoma, leiomyoma, other benign lesions, neuroendocrine tumors, and gastrointestinal stromal tumors with malignant potential. Furthermore, extraluminal compression by normal organs or benign lesions as well as other malignant tumors may have a similar appearance to gastric SET. Understanding the endoscopic and endoscopic ultrasound characteristics of common gastric subepithelial lesions can reduce the rate of unnecessary examinations and excessive treatment. In this article, these characteristics are reviewed through various images that are common in the Korean population.

위 종양의 내시경 점막하 박리술 후 발생하는 궤양 반흔에 대해 조직검사가 필요한가?

Do Hoon Kim 대한상부위장관ㆍ헬리코박터학회 2021 Korean Journal of Helicobacter Upper Gastrointesti Vol.21 No.1

위장관 운동 촉진제

송효엽,정성원,김용성 대한상부위장관ㆍ헬리코박터학회 2022 Korean Journal of Helicobacter Upper Gastrointesti Vol.22 No.2

Gastrointestinal (GI) prokinetic agents are drugs that increase GI motility and promote the movement of contents in the GI tract by amplifying and controlling the contraction of GI smooth muscle. Currently used prokinetics increase GI motility by acting as a dopamine D2 receptor antagonist (e.g., metoclopramide, domperidone, levosulpiride) and 5-HT4 receptor agonist (e.g., mosapride, prucalopride). Some prokinetics also have a cholinesterase inhibitory property (e.g., itopride), and herb-derived prokinetics (e.g., motilitone) affect multiple receptors. Depending on the type and distribution of receptors on which the prokinetics bind, the effect( s) may be regional or throughout the GI tract. Most prokinetics have been used for functional dyspepsia and gastroparesis because they mainly affect upper GI motility. However, prucalopride, a highly selective 5-HT4 receptor agonist, is used primarily to treat chronic constipation and pseudo-obstruction. Dopamine D2 receptor antagonists also inhibit the D2 receptor in the medulla oblongata chemoreceptor trigger zone; therefore, they can treat nausea and vomiting. However, short term use of dopamine D2 antagonists at an appropriate dose is recommended because of their potential for central nervous system side effects by penetrating the blood-brain barrier. It is necessary to know the mechanism of action, each clinical trial’s characteristics, and the side effects of prokinetics to obtain the best clinical outcomes. This article aims to summarize the results of clinical studies related to the impact of currently available prokinetic agents in Korea on GI motility.

장기간 양성자펌프억제제를 복용한 Helicobacter pylori 미감염자에서 발생한 위 체부의 비후와 출혈성 과형성 용종

정종현,이선영,한혜승 대한상부위장관ㆍ헬리코박터학회 2022 Korean Journal of Helicobacter Upper Gastrointesti Vol.22 No.1

A 22-year-old man presented with recurrent dizziness and melena. He had no remarkable medical history except for the reflux symptoms for which 18 months of proton pump inhibitor (PPI) intake was required. Gastroscopy revealed a 1-cm, blood-tinged polyp within the gastric rugae. A thickened gastric corpus was observed with a regular arrangement of collecting venules on its surface. Hyperplastic foveolar epithelium was observed in the biopsied specimens from the fundus and gastric rugae. The diagnosis after polypectomy was gastric hyperplastic polyp. Abdominal CT revealed hypertrophy only in the gastric corpus without antral involvement. Increased levels of serum pepsinogen I (>160 ng/mL), pepsinogen II (>50 ng/mL), chromogranin A (>1,800 ng/mL), and gastrin (534 pg/mL) were noted. Three months after PPI discontinuation, CT revealed improvement of the hypertrophic gastric corpus. Serum chromogranin A and gastrin levels decreased to 950.4 ng/mL and 517.0 pg/mL, respectively. Herein, we report a young, Helicobacter pylori-naive patient with prominent hyperplasia in the gastric corpus and a bleeding hyperplastic polyp after long-term PPI use.

프로바이오틱스는 헬리코박터 파일로리 제균 치료에 도움이 되는가?

심기남 대한상부위장관ㆍ헬리코박터학회 2023 Korean Journal of Helicobacter Upper Gastrointesti Vol.23 No.1

헬리코박터 파일로리균 감염에 대한 IMMULITE2000®의 GENEDIA®와의 정확성 비교

임선희,김나영,김성은,백광호,이주엽,박경식,신정은,송현주,명대성,최석채,김현진 대한상부위장관ㆍ헬리코박터학회 2020 Korean Journal of Helicobacter Upper Gastrointesti Vol.20 No.1

Background/Aims: In serological tests for Helicobacter pylori (H. pylori), an enzyme-linked immunosorbent assay (GENEDIA®) and a solid-phase, two-step chemiluminescent enzyme immunoassay (IMMULITE®), which are easy to perform, inexpensive, and widely available, are commonly used. However, local validation of the test performance of IMMULITE® is required. This study aimed to examine the performance of IMMULITE® in comparison with that of GENEDIA® in a Korean health checkup population. Materials and Methods: The sera of 300 subjects among those who underwent health checkup were analyzed using IMMULITE®, and results were compared with those of GENEDIA®. The two serological tests were compared for their ability to predict atrophic gastritis (AG) or intestinal metaplasia (IM) on endoscopy. Results: We found significant correlation (Pearson correlation coefficient=0.903, P<0.0001) and an almost perfect agreement (Cohen’s Kappa coefficient=0.987, P<0.0001) between the results of GENEDIA® and IMMULITE®. The area under the receiver operating characteristics curve (AUC) for AG using GENEDIA® and IMMULITE® were 0.590 and 0.604, respectively, and showed no statistically significant difference in predictive ability for AG (Z-statistics=-0.517, P=0.605). The AUC for IM by GENEDIA® and IMMULITE® were 0.578 and 0.593, respectively, with no statistically significant difference in predictive ability for IM between the two values (Z-statistics=-0.398, P=0.691). Conclusions: No statistically significant difference in diagnostic value for H. pylori infection was found between GENEDIA® and IMMULITE®.