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항코린에스테라제 독성에 대한 Histamine길항제의 효과
박은희,양근해,김오션 숙명여자대학교 약학연구소 1997 약학논문집-숙명여자대학교 Vol.13 No.-
This study was designed to examine the effects of antihistamines on the toxicity of neostigmine, a reversible cholinesterase inhibitor, in mice. Diphenhydramine and promethazine pretreatment increased the LD_(50) value of neostigmine by 2.15- and 3.65-fold, respectively. They also increased the onset times of toxic manifestations such as whole body tremor, loss of righting reflex and death. However, chlorcyclizine, chlorpromazine, i antazoline, chlorpheniramine and cimetidine pretreatment did not reduce the toxicities of neo-stigmine.
표명윤,유경미,최지선,오현정 숙명여자대학교 약학연구소 1993 약학논문집-숙명여자대학교 Vol.9 No.-
Effects of a new platinum complex, tetrachloro-[bis(2-chloroethyl) ethylenediamine-N,N']platinum(IV)[PtCl₄-2(CEen)] and cisplatin on the immune response were investigated. Male ICR mice were treated at the respective LD50(20% or 60% LD50) of cisplatin and PtCl₄-2(CEen). The results were as following : LD50 of PtCl₄-2(CEen) for male ICR mouse was 122.5mg/kg(i.p.) and higher than cisplatin(16.3mg/kg, i.p.). Body-, spleen-, thymus-, liver-weight, number of WBC and RBC were reduced dependently on the dose and day of administeration of cisplatin and PtCl₄-2(CEen). But these toxicities produced by PtC^-^CEen) appeared to be relatively less and to improve faster than by cisplatin. The titers of hemagglutinin and hemolysin to SRBC in mice received cisplatin and PtCl₄-2(CEen) were decreased significantly and independently on the day of antigen injection. Cisplatin and PtCl₄-2(CEen) stimulated significantly contact hypersensitivity to DNFB when administered prior to sensitization(DNFB), but suppressed slightly when administered after sensitization.
천연자원약물개발에 관한 연구 : 담쟁이덩굴이 흰쥐 신기능에 미치는 영향 Effect of Parthenocissus tricuspidata on rat kidney function
양기숙 숙명여자대학교 약학연구소 1996 약학논문집-숙명여자대학교 Vol.12 No.-
The Stem and the Radix of Parthenocissus tricuspidate (Vitaceae) have been used in arthrities laryngitis, jundice, neuralgia, renal insufficiency in folk remedies. In order to investigate the effects of their water extractums. on kidney function of normal and acute renal failure rats induced by the single s.c. injection of 2mg/kg HgCl_2, urinary volume, excretion rates of Na, K, Cl, serum chemical parameters were measured. The radix ex. 1.0g/kg showed significant diuretic action at 1-2hr. after administration. In renal failure group, the stem rather than the radix increase urin volume, electrolyte excretion at 2-5hr. after administration compared with 4-5hr. of furosemide and they didn't affect the level of serum parameters.
김태희,양기숙,류승옥 숙명여자대학교 약학연구소 1996 약학논문집-숙명여자대학교 Vol.12 No.-
Hemipteleae davidii(Ulmaceae) is a tree which is widely distributed in Korea and China. It has been used as treatment of cancer, diuretic, tuberculosis, anti-inflammatory agent in folk remedies. Lipid peroxide is associated with aging, diabetes, mutation and cancer. Therefore acute toxicity, carrageenin edema, anti-lipid peroxidation effect are examined. MeOH Ex. has none toxicity and show significant anticarrageenin action by dose dependence. Chloroform and ether fractions show potent inhibition of lipid peroxidation in vitro and in vivo. Butanol fraction in vitro, water fraction in vivo by does dependence had significant inhibition.
김태희,박지영 숙명여자대학교 약학연구소 1997 약학논문집-숙명여자대학교 Vol.13 No.-
Atherosclerotic cardiovascular dteeaaG(CAD) is the leading cause of death, and coronary artery disease is it5 major manifestation, Atherosclerosis is the end result of a multifactorial process that includes deposition of lipids, particularly cholesteryl ester, in (lie subintimal area of arteries Cichorium ifltybus (Compositae) has been os≪d for fevers, as a demulcent, for dy^p&psia, headache and jaundice, In order to approach pharmacotherapy of hyperlipidemia using a natural sources , Cichorium intybos was extracted with polar and nonpolar solvents, and we Avere examined protective activity on LDL oxidation, And also, electron donating effect by DPPH method was studied. The methanol and water extracts showed remarkable inhibition activity on hyperlipidemia. MeOH Ex. increased Electron donating ability according to concentration dependent.
Selenium이 마우스의 일차 체액성 면역반응과 접촉성 과민반응에 미치는 영향
최지선,표명윤 숙명여자대학교 약학연구소 2005 약학논문집-숙명여자대학교 Vol.22 No.-
Effects of Selenium (Se) on the primary humoral immune response and contact-delayed type hypersensitivity (CDTH) to 2,4-dinitro-l-fluorobenzene (DNFB) in normal and cyclophosphamide (CY)-treated mice. Se was orally administered via drinking water for 18 days (1ppm or 3ppm) or via intraperitoneal (i.p.) injection with a single dose of 0.05, 0.25, 0.5 mg/kg b.w. to normal and CY-treated mice. CY was i.p, injected to mice with a single dose of 10 or 50 mg/kg b.w. on the last day of Se-administration. When only Se was administered simultaneously with or after immunization, splenic IgM plaque forming cells (PFC) and hemmaglutinin-titer (HA-titer) in mice were not changed, however, decreased in the mice which were administered with high dose of Se before immunization. In addition, they were significantly increased in the concomitant treatment of CY and Se, compared to them in the only CY-treatment. Se significantly decreased DNFB-induced CDTH and inhibited the CY-enhanced CDTH. These results indicate that Se may inhibit the immunotoxicity induced by CY.
{5- [2-(Benzoxazol-2-ylmethylamino)ethoxy]-1-methylindol-3-yl}acetic acid의 합성 및 베타아밀로이드 응집억제 효과
김혜성,전라옥 숙명여자대학교 약학연구소 2004 약학논문집-숙명여자대학교 Vol.21 No.-
{5-[2-(Benzoxazol-2-ylmethylamino)ethoxy]-l-methyl-lH-indol-3-yl} acetic acid was designed and synthesized as β-amyloid (Aβ) fibril assembly inhibitors, and evaluated for inhibition of Aβ aggregation. Compound 7b provides a possible lead for further structural modification towards potential β-amyloid aggregation inhibitors to treat Alzheimer's disease.
김선영,양기숙 숙명여자대학교 약학연구소 2003 약학논문집-숙명여자대학교 Vol.19 No.-
Cordyceps species has been used as antiinflammatory, antitoxics, diuretics in folk remedies. Recent research has been reported the effect of anticancer, antidiabetic, antimutagenic, antilipid peroxidation, intestinal immune system modulating activity. Cordyceps pruinosa, which belongs to subgenus Eucordyceps of the Genus Cordyceps, Cordycopidaceae was observed in brown rice and bulled rice supplemented with milk. The activities of MeOH extract and its fraction from cultivated Cordyceps pruinosa on antifatigue activity induced by the mice forced swimming test were evaluated. Acute toxicity was investigated. The result revealed that BuOH and H₂O fractions showed significant antifatigue effect against immobilized stress. LD_(50) of each fraction was below 6g/kg.
골수세포를 이용한 파괄세포 분화 유도계에서 나타나는 세균 대사산물의 분화 억제 효과
임미정 숙명여자대학교 약학연구소 2003 약학논문집-숙명여자대학교 Vol.19 No.-
Bone turnover normally occurs in a highly regulated manner throughout life. It involves two different kinds of cells, osteoclasts and osteoblasts. Osteoclasts, the monocyte-macrophage lineage cells, resorb bone and osteoblasts deposit bone. Perturbations to these processes underlie skeletal disorders, such as osteoporosis. To understand the cellular and molecular mechanisms of bone biology and for the identification and characterization of new drug targets and therapies, a mouse co-culture system of osteoblasts and hematopoietic cells is established, in which osteoclasts are formed in response to 1 a ,25-dihydroxyvitamin D3 (1 a ,25(OH)₂D₃) and prostaglandin E₂ (PGE₂). Using this co-culture system, the bacterial metabolite n-butyrate, which has well-known anti-inflammatory effects, is shown to stimulate or inhibit osteoclastogenesis depending on the concentration. These results demonstrate a novel property of w-butyrate that may modulate osteoclastogenesis via osteoblasts.