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- 저자 : o-Villarreal, J. Humberto (검색결과 2 건)
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Isabel Hidalgo,Alicia Ortiz,Marı´a Sanchez-Pardo,Leticia Gardun˜o-Siciliano,Marcela Herna´ndez-Ortega,Francisco Villarreal,Eduardo Meaney,Nayelli Najera,Guillermo Manuel Ceballos 한국식품영양과학회 2019 Journal of medicinal food Vol.22 No.6
In the production of chocolate, only cocoa seeds are used, generating by-products that are generally discarded, increasing the risk of environmental contamination. Given fiber, carbohydrates, proteins, and flavonoid content the use of cacao pod husks can generate nutraceutical products for human consumption. In contrast, obesity represents a major public health problem worldwide. Cacao derivatives are able to modulate overweight and lipid disorders. The objective of present work was to prepare and characterize products using cacao by-products and analyze their effects on altered cardiometabolic risk markers in an obesity model induced by high fat diet and fructose ingestion in rats. The effects of a pellet and extracts made with outer pod husk and kernel husk for 5 weeks were analyzed in an obesity rat model. The treatments significantly decreased body weight by 39%, systolic blood pressure by 27%, triglycerides by 55%, total cholesterol by 24%, low-density lipoprotein cholesterol by 37%, and the triglycerides/high-density lipoprotein ratio by 54%. Cacao by-products improved the metabolic function of obese animals, without causing secondary effects
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Longchamp, Alban,Mirabella, Teodelinda,Arduini, Alessandro,MacArthur, Michael R.,Das, Abhirup,Treviñ,o-Villarreal, J. Humberto,Hine, Christopher,Ben-Sahra, Issam,Knudsen, Nelson H.,Brace, Lear E Elsevier 2018 Cell Vol.173 No.1
<P><B>Summary</B></P> <P>Angiogenesis, the formation of new blood vessels by endothelial cells (ECs), is an adaptive response to oxygen/nutrient deprivation orchestrated by vascular endothelial growth factor (VEGF) upon ischemia or exercise. Hypoxia is the best-understood trigger of VEGF expression via the transcription factor HIF1α. Nutrient deprivation is inseparable from hypoxia during ischemia, yet its role in angiogenesis is poorly characterized. Here, we identified sulfur amino acid restriction as a proangiogenic trigger, promoting increased VEGF expression, migration and sprouting in ECs <I>in vitro</I>, and increased capillary density in mouse skeletal muscle <I>in vivo</I> via the GCN2/ATF4 amino acid starvation response pathway independent of hypoxia or HIF1α. We also identified a requirement for cystathionine-γ-lyase in VEGF-dependent angiogenesis via increased hydrogen sulfide (H<SUB>2</SUB>S) production. H<SUB>2</SUB>S mediated its proangiogenic effects in part by inhibiting mitochondrial electron transport and oxidative phosphorylation, resulting in increased glucose uptake and glycolytic ATP production.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Sulfur amino acid (SAA) restriction triggers angiogenesis independent of hypoxia or HIF1α </LI> <LI> GCN2/ATF4 pathway regulates VEGF and CGL expression upon SAA restriction in ECs </LI> <LI> CGL is required for skeletal muscle angiogenesis activated by diet or exercise </LI> <LI> H<SUB>2</SUB>S triggers glucose uptake, glycolysis, and PPP concomitant with OXPHOS inhibition in ECs </LI> </UL> </P> <P><B>Graphical Abstract</B></P> <P>[DISPLAY OMISSION]</P>
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