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RISS 인기검색어
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- 저자 : koski, Johanna (검색결과 4 건)
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Size-Controlled Self-Assembly of Superparamagnetic Polymersomes
Hickey, Robert J.,Koski, Jason,Meng, Xin,Riggleman, Robert A.,Zhang, Peijun,Park, So-Jung American Chemical Society 2014 ACS NANO Vol.8 No.1
<P>We report the size-controlled self-assembly of polymersomes through the cooperative self-assembly of nanoparticles and amphiphilic polymers. Polymersomes densely packed with magnetic nanoparticles in the polymersome membrane (magneto-polymersome) were fabricated with a series of different sized iron oxide nanoparticles. The distribution of nanoparticles in a polymersome membrane was size-dependent; while small nanoparticles were dispersed in a polymer bilayer, large particles formed a well-ordered superstructure at the interface between the inner and outer layer of a bilayer membrane. The yield of magneto-polymersomes increased with increasing the diameter of incorporated nanoparticles. Moreover, the size of the polymersomes was effectively controlled by varying the size of incorporated nanoparticles. This size-dependent self-assembly was attributed to the polymer chain entropy effect and the size-dependent localization of nanoparticles in polymersome bilayers. The transverse relaxation rates (<I>r</I><SUB>2</SUB>) of magneto-polymersomes increased with increasing the nanoparticle diameter and decreasing the size of polymersomes, reaching 555 ± 24 s<SUP>–1</SUP> mM<SUP>–1</SUP> for 241 ± 16 nm polymersomes, which is the highest value reported to date for superparamagnetic iron oxide nanoparticles.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/ancac3/2014/ancac3.2014.8.issue-1/nn405012h/production/images/medium/nn-2013-05012h_0007.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/nn405012h'>ACS Electronic Supporting Info</A></P>
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WDR11‐mediated Hedgehog signalling defects underlie a new ciliopathy related to Kallmann syndrome
Kim, Yeon‐,Joo,Osborn, Daniel PS,Lee, Ji‐,Young,Araki, Masatake,Araki, Kimi,Mohun, Timothy,Kä,nsä,koski, Johanna,Brandstack, Nina,Kim, Hyun‐,Taek,Miralles, Francesc,Kim, Cheo John Wiley and Sons Inc. 2018 EMBO reports Vol.19 No.2
<P><B>Abstract</B></P><P>WDR11 has been implicated in congenital hypogonadotropic hypogonadism (CHH) and Kallmann syndrome (KS), human developmental genetic disorders defined by delayed puberty and infertility. However, WDR11's role in development is poorly understood. Here, we report that WDR11 modulates the Hedgehog (Hh) signalling pathway and is essential for ciliogenesis. Disruption of WDR11 expression in mouse and zebrafish results in phenotypic characteristics associated with defective Hh signalling, accompanied by dysgenesis of ciliated tissues. <I>Wdr11</I>‐null mice also exhibit early‐onset obesity. We find that WDR11 shuttles from the cilium to the nucleus in response to Hh signalling. WDR11 regulates the proteolytic processing of GLI3 and cooperates with the transcription factor EMX1 in the induction of downstream Hh pathway gene expression and gonadotrophin‐releasing hormone production. The CHH/KS‐associated human mutations result in loss of function of WDR11. Treatment with the Hh agonist purmorphamine partially rescues the WDR11 haploinsufficiency phenotypes. Our study reveals a novel class of ciliopathy caused by WDR11 mutations and suggests that CHH/KS may be a part of the human ciliopathy spectrum.</P>
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The evolution and current state of bariatric endoscopy in Western countries
Maria Valeria Matteo,Vincenzo Bove,Valerio Pontecorvi,Loredana Gualtieri,Giorgio Carlino,Cristiano Spada,Ivo Boškoski 대한소화기내시경학회 2024 Clinical Endoscopy Vol.57 No.6
With the alarmingly increasing prevalence of obesity in the Western world, it has become necessary to provide more acceptable treatment options for patients with obesity. Minimally invasive endoscopic techniques are continuously evolving. Currently, metabolic and bariatric endoscopies encompass several different techniques that can offer significant weight loss and improvement in comorbidities with a favorable safety profile. Restrictive bariatric procedures include the use of intragastric balloons and gastric remodeling techniques with different suturing devices. Several studies have demonstrated the efficacy and safety of these techniques that are widely used in clinical practice. Small intestine-targeted metabolic endoscopy is an intriguing and rapidly evolving field of research, although it is not widespread in routine practice. These techniques include duodenal-jejunal bypass liners, duodenal mucosal resurfacing, and incisionless anastomoses. The aim of this review article is to provide a detailed update on the currently available bariatric endoscopy techniques in Western countries.
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