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Trichel Pulse in Negative DC Corona discharge and Its Electromagnetic Radiations
Zhang, Yu,Liu, Li-Juan,Miao, Jin-Song,Peng, Zu-Lin,Ouyang, Ji-Ting The Korean Institute of Electrical Engineers 2015 Journal of Electrical Engineering & Technology Vol.10 No.3
We investigate in this paper the radiated electromagnetic waves together with the discharge characteristics of Trichel pulse of negative DC corona discharge in air in pin-to-plate and wire-to-plate configurations. The feature of the current pulse and the frequency spectrum of the electromagnetic radiations were measured under various pressures and gas gaps. The results show that the repetition frequency and the amplitude of Trichel pulse current depend on the discharge conditions, but the rising time of the pulse relates only to the radius of needle or wire and keeps constant even if the other conditions (including the discharge current, the gas gap and the gas pressure) change. There exists the characterized spectrum of electromagnetic waves from negative corona discharge in Trichel pulse regime. These characterized radiations do not change their frequency at a given cathode geometry even if the averaged current, the gas gap or the air pressure changes, but the amplitude of radiations changes accordingly. The characterized electromagnetic radiations from Trichel pulse corona relate to the formation or the rising edge of current pulse. It confirms that the characterized radiations from Trichel pulse supply information of discharge system and provide a potential method for detecting charged targets.
Trichel Pulse in Negative DC Corona discharge and Its Electromagnetic Radiations
Yu Zhang,Li-Juan Liu,Jin-Song Miao,Zu-Lin Peng,Ji-Ting Ouyang 대한전기학회 2015 Journal of Electrical Engineering & Technology Vol.10 No.3
We investigate in this paper the radiated electromagnetic waves together with the discharge characteristics of Trichel pulse of negative DC corona discharge in air in pin-to-plate and wire-to-plate configurations. The feature of the current pulse and the frequency spectrum of the electromagnetic radiations were measured under various pressures and gas gaps. The results show that the repetition frequency and the amplitude of Trichel pulse current depend on the discharge conditions, but the rising time of the pulse relates only to the radius of needle or wire and keeps constant even if the other conditions (including the discharge current, the gas gap and the gas pressure) change. There exists the characterized spectrum of electromagnetic waves from negative corona discharge in Trichel pulse regime. These characterized radiations do not change their frequency at a given cathode geometry even if the averaged current, the gas gap or the air pressure changes, but the amplitude of radiations changes accordingly. The characterized electromagnetic radiations from Trichel pulse corona relate to the formation or the rising edge of current pulse. It confirms that the characterized radiations from Trichel pulse supply information of discharge system and provide a potential method for detecting charged targets.
Ling Chen,Jing Zhong,Jiang-Hua Liu,Duan-Fang Liao,Ying-Ying Shen,Xiao-Lin Zhong,Xiao Xiao,Wen-Jun Ding,Xiu-Da Peng,Wei Xiong,Xu-Yu Zu 한국유방암학회 2019 Journal of breast cancer Vol.22 No.1
Purpose: Pokemon, also known as ZBTB7A, belongs to the POZ and Krüppel (POK) family of transcription repressors and is implicated in tumor progression as a key proto-oncogene. This present study aimed at determining the mechanism by which Pokemon inhibits transforming growth factor β (TGFβ)-Smad4 pathway-dependent proliferation arrest of breast cancer cells via specificity protein 1 (SP1). Methods: Over-expressing plasmid or small interfering RNA (siRNA) transfection was used to regulate Pokemon levels. The EdU incorporation assay, MTS assay, and clone formation were used to identify the inhibitory effect of Pokemon siRNA on cell proliferation. Quantitative real-time polymerase chain reaction assay confirmed that Pokemon deletion inhibited the expression of proliferation-associated genes. The dual-luciferase reporter assay, electrophoretic mobility shift assay, and co-immunoprecipitation assay were used to analyze binding between Pokemon, Smad4, and SP1. Results: Pokemon deletion induced proliferation arrest of breast cancer cells and inhibited the expression of proliferation-associated genes, especially Smad4. Pokemon bound with SP1 to interdict Smad4 promoter activity. Information on clinical samples was obtained from The Cancer Genome Atlas data, in which the Pokemon mRNA levels showed a negative correlation with Smad4 levels in different subtypes of breast cancer in two independent datasets. Conclusion: We demonstrated that Pokemon binds to SP1 to down-regulate Smad4 expression, thereby promoting proliferation of breast cancer cells. This suggests that Pokemon is a potential TGFβ-signaling participant in breast cancer progression.