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Zhou Weilun,Wu Cuiping,Wang Jiao 대한독성 유전단백체 학회 2023 Molecular & cellular toxicology Vol.19 No.3
Background Emerging evidence has revealed that circular RNAs (circRNAs) are critical regulators for the development of various tumors, containing diff use large B-cell lymphoma (DLBCL). CircRNA microarray analysis suggested that circ_0000877 was freakishly increased in DLBCL tissues. Objective This study is designed to explore the role and mechanism of circ_0000877 on DLBCL development. Results Circ_0000877 and HK2 were increased, and miR-671-5p was reduced in DLBCL tissues and cell lines. Also, circ_0000877 silencing hindered DLBCL cell proliferation and glycolysis, and induced apoptosis in vitro. Mechanically, circ_0000877 functioned as a sponge of miR-671-5p, and circ_0000877 knockdown-mediated DLBCL cell development inhibition was relieved by miR-671-5p downregulation. Moreover, HK2 acted as a direct target gene of miR-671-5p, and enhanced HK2 might abolish the impact of miR-671-5p on DLBCL cell progression. Conclusion Circ_0000877 silencing mitigated DLBCL cell malignant biological behavior partly via miR-671-5p/HK2 axis, referring to circ_0000877 as an underlying prognostic biomarker. These data provided a promising strategy for treating DLBCL malignancies.