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Opportunities and Challenges of in vitro Synthetic Biosystem for Terpenoids Production
Yang Liyang,Gong Qiang,Lv Jifang,Zhou Bangyuan,Li Guilan,Guo JianQuan 한국생물공학회 2022 Biotechnology and Bioprocess Engineering Vol.27 No.5
Terpenoids are a large variety of natural products with remarkable diverse biological functions, and have a wide range of applications in flavors, pharmaceuticals, biofuels, pigments, and so on. However, limited production of terpenoids from natural resources constrains their use of bulk commodity products. In vivo synthetic biosystem, harnessing living organisms to produce terpenoids, has been broadly used and in-depth reviewed for terpenoids production, which has inherent weaknesses, such as slow reaction rate, low product yield, toxic intermediates, and high separation cost. In vitro synthetic biosystem, harboring numerous enzymes and/or coenzymes assembled into an in vitro enzymatic bioreactions, can obviate part of problems associated with in vivo style. In this review, the general design of in vitro synthetic biosystem is presented with seven supporting examples: mevalonate, isoprene, limonene, pinene, farnesene, amorpha-4,11-diene and taxadiene. The efforts for the large-scale implementation of in vitro synthetic biosystem have been addressed to enzymes engineering, computational modeling and cofactors recycle. The review also discusses the challenges and solutions for the largescale implementation of in vitro synthetic biosystem around enzymes stability and cofactors recycle. This review may suggest in vitro synthetic biosystems become a realistic option for the production of diverse valuable terpenoids, even expand to other commodity chemicals.
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