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- 검색키워드
- 저자 : Zhengkai Wei (검색결과 3 건)
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Zhengkai Wei,Yi Wang,Xiaowei Fu,Liang Jiang,Yuechuan Wang,Anqian Yuan,Hualiang Xu,Jingxin Lei 한국고분자학회 2021 Macromolecular Research Vol.29 No.8
The thermosetting polyurea possessed high tensile strength and elongations at break due to strong intermolecular interactions, but their recycling and reprocessing remains a great challenge, especially at a temperature below 100℃. Herein, the novel crosslinked polyurea with excellent recycling and reprocessing properties has been prepared by introducing the Diels-Alder dynamic covalent bond. The chemical structure, thermal mechanical properties and reprocessing performance of the crosslinked polyurea were investigated. The prepared polyurea has low relaxation time of ~4 min at 80℃ for facile reprocessing. The tensile strength and elongation at break of crosslinked polyurea could reach 15.24 MPa and 529.2%, respectively, and its mechanical properties remain almost unchanged even after repeated processing. This work has realized the recycling of crosslinked polyurea, which has huge potential applications in environmental protection and recycling of waste plastics.
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Paclitaxel targeting to lungs by way of liposomes prepared by the effervescent dispersion technique
Yumeng Wei,Zhengkai Xue,Yun Ye,Yu Huang,Ling Zhao 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.6
In order to develop a novel lung targeting drugdelivery system (LTDDS) with large-sized liposomescontaining paclitaxel (PTX), the liposomes composed ofPTX, phosopholipon 90H and tween-80 were prepared bythe effervescent dispersion technique with optimal formulationcomposition. The liposomes were found to be relativelyuniform in particle size (8.166 ± 0.459 lm) with anegative zeta-potential (-12.45 ± 1.34 mv), and highentrapment efficiency (92.20 ± 2.56 %). They kept stablefor at least 3 months and exhibited a slow release behaviorwithout any hemolysis reaction. Via intravenous administrationin rabbits, the PTX liposomes presented a longermean residence time and elimination half-life, and a muchlarger area under the plasma drug concentration–time curvecompared with its injection; meanwhile, the liposomesaltered its biodistribution and exhibited a significant lungtargeting characteristic. For example, the relative intakerate (Re) and the ratio of peak concentration (Ce) of lungwere 14.87 and 26.44, respectively. Compared with heart,liver, spleen and kidney, the ratios of targeting efficacy(Te)liposomes to (Te)injection of lung were increased by afactor of 20.08, 11.10, 6.97 and 14.41, respectively. To sum up, the liposome could be a promising drug carrier forPTX as LTDDS for lung cancer treatment.
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Yumeng Wei,Zhengkai Xue,Peng Wang,Ling Zhao 대한약학회 2013 Archives of Pharmacal Research Vol.36 No.7
A novel sustained-release system was developedfor poorly water-soluble drugs by applying soliddispersion (SD) technique to improve the solubility. TheSD systems composed of polyvinyl pyrrolidone and stearicacid could not control the release of nifedipine. When theabove SD granules were coated with ethylcellolulose(EC10, 45 and 100cp), the dissolution rate extended from16 to 20 h. When the concentration of EC100cp wasincreased to 4–6 %, the sustained-release formulation F7and F8 prepared with 4 % EC100cp and 6 % EC100cp,respectively, could control the drug release in a bettermanner, namely, they could control drug release in theinitial hours with a high cumulative amount of drug at24 h. The mechanism of drug release from F7 and F8 wasdiffusion coupled with erosion. When immediate-releasecapsules was orally administered to rabbits, its absorptionwas very rapid with a short elimination half-life, while aprolonged maintenance of the plasma drug level up to 24 hwas obtained for F7 and F8. Furthermore, the oral bioavailabilityof F7 and F8 was significantly improved. Theresults suggested that this novel sustained-release systemwould be a promising system to improve the solubility andsustain the absorption of poorly water-soluble drugs.
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