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RISS 인기검색어
- 검색키워드
- 저자 : Zhe Nie (검색결과 3 건)
- 무료
- 기관 내 무료
- 유료
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Zhu, Zhe,Wang, Cun-Ping,Zhang, Yin-Feng,Nie, Lin Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.2
Chondrosarcomas are malignant cartilage-forming tumors of bone which exhibit resistance to both chemotherapy and radiation treatment. miRNAs have been well demonstrated to regulate gene expression and play essential roles in a variety of biological processes, including proliferation, differentiation, migration, cell cycling and apoptosis. In this study, we obtained evidence that miR-100 acts as a tumor suppressor in human chondrosarcomas. Interestingly, cisplatin resistant chondrosarcoma cells exhibit decreased expression of miR-100 compared with parental cells. In addition, we identified mTOR as a direct target of miR-100. Overexpression of miR-100 complementary pairs to the 3' untranslated region (UTR) of mTOR, resulted in sensitization of cisplatin resistant cells to cisplatin. Moreover, recovery of the mTOR pathway by overexpression of S6K desensitized the chondrosarcoma cells to cisplatin, suggesting the miR-100-mediated sensitization to cisplatin dependent on inhibition of mTOR. In summary, the present studies highlight miR-100 as a tumor suppressor in chondrosarcoma contributing to anti-chemoresistance. Overexpression of miR-100 might be exploited as a therapeutic strategy along with cisplatin-based combined chemotherapy for the treatment of clinical chondrosarcoma patients.
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Compressive behavior of built-up open–section columns consisting of four cold-formed steel channels
Shaofeng Nie,Cunqing Zhao,Zhe Liu,Yong Han,Tianhua Zhou,Hanheng Wu 국제구조공학회 2022 Steel and Composite Structures, An International J Vol.45 No.6
Compression experiments were conducted to investigate the compressive behavior of built-up open-section columns consisting of four cold-formed steel channels (BOCCFSs) of different lengths, thicknesses, and cross-section sizes (OB90 and OB140). The load-displacement curves, failure modes, and maximum compression strength values were analyzed in detail. The tests showed that the failure modes of the OB90 specimens transformed from a large deformation concentration induced by local buckling to flexural buckling with the increase in the slenderness ratio. The failure modes of all OB140 specimens were deformation concentration, except for one long specimen, whose failure mode was flexural buckling. When the slenderness ratios of the specimens were less than 55, the failure modes were controlled by local buckling. Finite element models were built using ABAQUS software and validated to further analyze the mechanical behavior of the BOCCFSs. A parametric study was conducted and used to explore a wide design space. The numerical analysis results showed that when the screw spacing was between 150 mm and 450 mm, the difference in the maximum compression strength values of the specimens was less than 4%. The applicability and effectiveness of the design methods in Chinese GB50018-2002 and AISI-S100-2016 for calculating the compression strength values of the BOCCFSs were evaluated. The prediction methods based on the assumptions produced predictions of the strength that were between 33% to 10% conservative as compared to the tests and the finite element analysis.
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Haibo Yi,Weijian Li,Zhe Nie 보안공학연구지원센터 2016 International Journal of Security and Its Applicat Vol.10 No.9
Inversions in small finite fields are the most computationally intensive field arithmetic and have been playing a key role in areas of cryptography and engineering. The main algorithms for small finite field inversions are based on Fermat's little theorem, extended Euclidean algorithm, Itoh-Tsujii algorithm and other methods. In this brief, we present techniques to exploit special irreducible polynomials for fast inversions in small finite fields GF(2n) , where n is a positive integer and 0 < n < 16 . Then, we propose fast inversions based on Fermat's theorem for two special irreducible polynomials in small finite fields, i.e. trinomials and All-One-Polynomials (AOPs). Trinomials can be represented by polynomials xn + xm + 1 and AOPs can be represented by polynomials xn + Xn-1 + ... +1 , where m is a positive integer and 0 < m < n . Our designs have low hardware requirements, regular structures and are therefore suitable for hardware implementation. After that, our designs are programmed in Very-High-Speed Integrated Circuit Hardware Description Language (VHDL) by using integrated environment Altera Quartus II and implemented on a low-cost Field- Programmable Gate Array (FPGA). The experimental results on FPGAs show that our designs provide significant reductions in executing time of inversions in small finite fields, e.g. the executing time of inversion in GF(27) is 18.80 ns and the executing time of inversion in GF(212) is 29.57 ns.
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