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Hypoxia-induced circRNF13 promotes the progression and glycolysis of pancreatic cancer
Zhao Qiuyan,Zhu Zhonglin,Xiao Wenqin,Zong Guanzhao,Wang Chuanyang,Jiang Weiliang,Li Kai,Shen Jie,Guo Xingya,Cui Jianhua,Guo Lihong,Wan Rong 생화학분자생물학회 2022 Experimental and molecular medicine Vol.54 No.-
Pancreatic cancer (PC) is one of the most malignant tumors. Rapid progression and distant metastasis are the main causes of patient death. Hypoxia is a hallmark of multiple cancers and is involved in tumor biology. However, little is known about the roles of circRNAs in glycolysis and hypoxia-mediated progression of PC. Here, the expression pattern of hypoxia-related circRNAs was analyzed using RNA sequencing. A unique circRNA termed circRNF13 was found to be upregulated in PC tissues and may be a potential prognostic indicator. HIF-1α and EIF4A3 are involved in regulating the biogenesis of circRNF13. Furthermore, circRNF13 was validated to exert a stimulative effect on cell proliferation, angiogenesis, invasion and glycolysis. Importantly, we found that circRNF13 promoted PDK3 levels by acting as a miR-654-3p sponge, thus promoting the PC malignant process. Collectively, our results reveal that hypoxia-induced circRNF13 mediated by HIF-1α and EIF4A3 promotes tumor progression and glycolysis in PC, indicating the potential of circRNF13 as a prognostic biomarker and therapeutic target for PC.
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Public Access to Government Information in the Digital Age: Findings from China
Sun Yu,Dang Shengcui,Fang Bin,Zhao Qiuyan 한국사회과학협의회 2014 Korean Social Science Journal Vol.41 No.1
The openness of government information is an unavoidable issue in the digitalage. The Chinese government makes great effort to publish administrative information andseek advice on good governance from the general public, but is nonetheless unable to meetcitizens’ legitimate demands for the right to know and participate. This study analyzes thiscontradiction from four angles: the driving force, the type of information, the accessplatform, and the annual examination and supervision system for government informationdisclosure. The findings showed that (a) netizens’ heavy pressure rather than Chineseauthorities’ strong leadership pushes forward the disclosure of government information;(b) administrative information concerning the public agenda rather than the policy agendabest meets the needs of the general public; (c) commercial Weibo websites are a moresatisfactory channel than official government websites for practical requests; and (d) as aunique institutional arrangement for examination and supervision, the annual report ongovernment information disclosure should be standardized.
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