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- 저자 : Zhao Qianqi (검색결과 2 건)
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Differential Profile of Plasma Circular RNAs in Type 1 Diabetes Mellitus
Yangyang Li,Ying Zhou,Minghui Zhao,Jing Zou,Yuxiao Zhu,Xuewen Yuan,Qianqi Liu,Hanqing Cai,Cong-Qiu Chu,Yu Liu 대한당뇨병학회 2020 Diabetes and Metabolism Journal Vol.44 No.6
Background No currently available biomarkers or treatment regimens fully meet therapeutic needs of type 1 diabetes mellitus (T1DM). Circular RNA (circRNA) is a recently identified class of stable noncoding RNA that have been documented as potential biomarkers for various diseases. Our objective was to identify and analyze plasma circRNAs altered in T1DM. Methods We used microarray to screen differentially expressed plasma circRNAs in patients with new onset T1DM (n=3) and age-/gender-matched healthy controls (n=3). Then, we selected six candidates with highest fold-change and validated them by quantitative real-time polymerase chain reaction in independent human cohort samples (n=12). Bioinformatic tools were adopted to predict putative microRNAs (miRNAs) sponged by these validated circRNAs and their downstream messenger RNAs (mRNAs). Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses were performed to gain further insights into T1DM pathogenesis. Results We identified 68 differentially expressed circRNAs, with 61 and seven being up- and downregulated respectively. Four of the six selected candidates were successfully validated. Curations of their predicted interacting miRNAs revealed critical roles in inflammation and pathogenesis of autoimmune disorders. Functional relations were visualized by a circRNA-miRNA-mRNA network. GO and KEGG analyses identified multiple inflammation-related processes that could be potentially associated with T1DM pathogenesis, including cytokine-cytokine receptor interaction, inflammatory mediator regulation of transient receptor potential channels and leukocyte activation involved in immune response. Conclusion Our study report, for the first time, a profile of differentially expressed plasma circRNAs in new onset T1DM. Further in silico annotations and bioinformatics analyses supported future application of circRNAs as novel biomarkers of T1DM.
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State-of-the-Art Review on Topology and Deductive Methods of LLC Resonant Converter
Li Yazhuo,Cheng Xu-Feng,Zhao Jiapeng,Zhao Qianqi,Li He,Zhang Yu,Hao Xin 대한전기학회 2024 Journal of Electrical Engineering & Technology Vol.19 No.4
The LLC resonant converter has many advantages, such as low operating loss, wide output range, small size, and simple structure. It is widely used in the fi elds of automobile charging, special power supply, and new energy power generation. Topology is a very important part of the LLC resonant converter. However, at present, the overview of LLC resonant converter topology only briefl y summarizes some traditional topologies, which cannot cover the emerging new topologies. In this paper, the topology and deductive methods of LLC resonant converter, which concerns the literatures in the past fi ve years, are reviewed. At the same time, for the integrity of this article, the modulation strategy of the LLC converter is introduced briefl y. This paper fi rstly introduces the basic working principle and characteristics of the LLC resonant converter, and then discusses the basic topology and modulation strategy of the LLC resonant converter. Classifi cation and deductive methods of related topologies are summarized in detail, and the related results help engineers analyze, select, and design LLC resonant converters. Finally, the future development trend of LLC resonant converter is predicted and discussed according to the status of industrial applications.
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