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Differential die-away technology applied to detect special nuclear materials
Lianjun Zhang,Mengjiao Tang,Chen Zhang,Yulai Zheng,Yong Li,Chao Liu,Qiang Wang,Guobao Wang Korean Nuclear Society 2023 Nuclear Engineering and Technology Vol.55 No.7
Differential die-away analysis (DDAA) technology is a special nuclear material (SNM) active detection analysis technology. Be a nuclear material shielded or not, the technology can reveal the existence of nuclear materials by inducing fission from an external pulsed neutron source. In this paper, a detection model based on DDAA analysis technology was established by geant4 Monte Carlo simulation software, and the optimal sensitivity of the detection system is achieved by optimizing different configurations. After the geant4 simulation and optimization, a prototype was established, and experimental research was carried out. The result shows that the prototype can detect 200 g of <sup>235</sup>U in a steel cylinder shield that's of 1.5 cm in inner diameter, 10 cm in thickness and 280 kg in weight.
Synthesis and electrochemical applications of nitrogen-doped carbon nanomaterials
Majeed, Saadat,Zhao, Jianming,Zhang, Ling,Anjum, Saima,Liu, Zhongyuan,Xu, Guobao Walter de Gruyter GmbH 2013 Nanotechnology Reviews Vol.2 No.6
<B>Abstract</B><P>Nitrogen doping is an effective way to tailor the properties of the shaped carbon materials, including the nanotubes, nanocups, nanofibers, as well as the nanorods, and render their potential use for various applications. The common bonding configurations obtained on the N insertion is the pyridinic N and pyrrolic N, which impart the characteristic properties to these carbon materials. This review will focus on the nitrogen-doped carbon materials, the doping effect on the electrochemistry of the doped nanomaterials, and the various synthetic methods to introduce N into the carbon network. The potential applications of the N-doped materials are also reviewed on the basis of the experimental and theoretical studies in electrochemistry.</P>
Shuai Wang,Li Lyu,Guobao Sima, Ying Cui,Ying Cui,Baoxia Li,Xueqin Zhang,Linhuo Gan 한국화학공학회 2019 Korean Journal of Chemical Engineering Vol.36 No.7
A sulfonated lignin-derived mesoporous carbon (LDMC-SO3H) was prepared from kraft lignin (KL) using phenolation and soft-template method followed by sulfonation. LDMC-SO3H bearing a sulfonic acid density of 0.65 mmol/g possessed a well-ordered 2D hexagonal mesoporous characteristics with mesopore volume of 0.067 cm3/g and specific surface area of 262m2/g as well as mesopore size of 3.42 nm. A high 5-hydroxymethylfurfural (5-HMF) yield of 98.0% with a full fructose conversion was obtained using LDMC-SO3H as catalyst under the optimized reaction conditions of reaction temperature and time of 140 oC and 120 min, initial fructose concentration of 100 g/L, catalyst load of 0.1mg/mg in DMSO. Furthermore, there was no obvious decrease in 5-HMF yield (95.0%) within the fivecycle experiment, highlighting the superior reusability and stability of LDMC-SO3H in fructose-to-5-HMF transformation.
Expanding the Diversity of Allosteric Bcr-Abl Inhibitors
Deng, Xianming,Okram, Barun,Ding, Qiang,Zhang, Jianming,Choi, Yongmun,Adriá,n, Francisco J.,Wojciechowski, Amy,Zhang, Guobao,Che, Jianwei,Bursulaya, Badry,Cowan-Jacob, Sandra W.,Rummel, Gabriele American Chemical Society 2010 Journal of medicinal chemistry Vol.53 No.19
<P/><P>Inhibition of Bcr-Abl kinase activity by imatinib for the treatment of chronic myeloid leukemia (CML) currently serves as the paradigm for targeting dominant oncogenes with small molecules. We recently reported the discovery of GNF-2 (<B>1</B>) and GNF-5 (<B>2</B>) as selective non-ATP competitive inhibitors of cellular Bcr-Abl kinase activity that target the myristate binding site. Here, we used cell-based structure−activity relationships to guide the optimization and diversification of ligands that are capable of binding to the myristate binding site and rationalize the findings based upon an Abl−compound <B>1</B> cocrystal. We elucidate the structure−activity relationships required to obtain potent antiproliferative activity against Bcr-Abl transformed cells and report the discovery of new compounds (<B>5g</B>,<B> 5h</B>,<B> 6a</B>,<B> 14d</B>, and <B>21j-I)</B> that display improved potency or pharmacological properties. This work demonstrates that a variety of structures can effectively target the Bcr-Abl myristate binding site and provides new leads for developing drugs that can target this binding site.</P>