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RISS 인기검색어
- 검색키워드
- 저자 : Zeinab Salah (검색결과 3 건)
- 무료
- 기관 내 무료
- 유료
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Oleuropein Induces Apoptosis Via the p53 Pathway in Breast Cancer Cells
Hassan, Zeinab Korany,Elamin, Maha Hussein,Omer, Sawsan Ali,Daghestani, Maha Hassan,Al-Olayan, Ebtesam Salah,Elobeid, Mai AbdelRahman,Virk, Promy Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.11
Background: Breast cancer is a major health problem worldwide. Olive oil induces apoptosis in some cancer cells due to phenolic compounds like oleuropein. Although oleuropein has anticancer activity, the underlying mechanisms of action remain unknown. The study aimed to assess the mechanism of oleuropin-induced breast cancer cell apoptosis. Materials and Methods: p53, Bcl-2 and Bax gene expression was evaluated by semi-quantitative reverse transcriptase polymerase chain reaction (RT-PCR) in luminal MCF-7 cells. Results: Oleuropein-induced apoptosis was accompanied by up-regulation of both p53 and Bax gene expression levels and down-regulation in Bcl2. Conclusions: Oleuropein induces apoptosis in breast tumour cells via a p53-dependent pathway mediated by Bax and Bcl2 genes. Therefore, oleuropein may have therapeutic potential in breast cancer patients by inducing apoptosis via activation of the p53 pathway.
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Ibrahim Abdelmageid Hassan,Sara Said,Zeinab Salah,Mohamad Magdy Abdel Wahab 한국대기환경학회 2022 Asian Journal of Atmospheric Environment (AJAE) Vol.16 No.2
The changes in air quality were investigated in six megacities during the shutdown phases in 2020 and were compared to the same time periods in the previous 10 years (2010-2019) using the data of Modern-Era Retrospective Analysis and Research and Application, version 2 (MERRA-2). The concentrations of PM10 and PM2.5 were greatly reduced in all megacities during the lockdown in 2020 when compared to the same period in 2019 and in the previous ten years. The highest reduction in PM10 was recorded in Delhi, and São Paulo (21%, and 15% and by 27%, and 9%), when compared with the concentrations in 2019 and in the period 2010-2019, respectively. Similarly, levels of PM2.5 in Delhi, São Paulo, Beijing, and Mumbai decreased by 20%, 14%, 12%, and 10%, respectively in 2020 when compared to the last ten years. Results indicated that the lockdown is an effective mitigation measure to improve air quality. The MERRA-2 reanalysis dataset could be a vital tool in air quality studies in places with a lack of In-situ observations.
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Soliman, Nema Ali,Keshk, Walaa Arafa,Shoheib, Zeinab Salah,Ashour, Dalia Salah,Shamloula, Maha Moustafa Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.3
Background: Schistosomiasis is a parasitic disease causing chronic ill health in humans with a serious consequences for socio-economic development in tropical and subtropical regions. There is also evidence linking Schistosoma mansoni to colonic carcinoma occurrence. The aim of this study was to evaluate some inflammatory and oxidative stress biomarkers, as well as L-fucose as linkers between intestinal schistosomiasis and colonic dysplasia development in mice. Materials and Methods: This study was conducted upon 80 mice that were divided the control group (10 non infected mice) and infected group which was subdivided into 7 sub-groups (10 mice each) according to the time of sacrifaction in the post infection (p.i.) period, 10 mice being sacrificed every two weeks from 6 weeks p.i. to 18 weeks p.i. Tumor necrosis factor alpha (TNF-${\alpha}$), inducible nitric oxide synthase (iNOS), and pentraxin 3 (PTX3) levels were estimated by immunoassay. The L-fucose level, and thioredoxin reductase (TrxR) and lactate dehydrogenase (LDH) activities were also evaluated in colonic tissue. Results: The current study revealed statistically significant elevation in the studied biochemical markers especially at 16 and 18 weeks p.i. The results were confirmed by histopathological examination that revealed atypical architectural and cytological changes in the form of epithelial surface serration and nuclear hyper-chromatizia at 14, 16 and 18 weeks p.i. Conclusions: inflammation, oxidative stress and L-fucose together may form an important link between Schistosomal mansoni infection and colonic dysplasia and they can be new tools for prediction of colonic dysplasia development in experimental schistosomiasis.
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