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- 저자 : Zaraket, Hassan (검색결과 1 건)
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Wong, Sook-San,Yoon, Sun-Woo,Zanin, Mark,Song, Min-Suk,Oshansky, Christine,Zaraket, Hassan,Sonnberg, Stephanie,Rubrum, Adam,Seiler, Patrick,Ferguson, Angela,Krauss, Scott,Cardona, Carol,Webby, Richard Elsevier 2014 Virology Vol.468 No.-
<P><B>Abstract</B></P> <P>The cleavage motif in the hemagglutinin (HA) protein of highly pathogenic H5 and H7 subtypes of avian influenza viruses is characterized by a peptide insertion or a multibasic cleavage site (MBCS). Here, we isolated an H4N2 virus from quails (Quail/CA12) with two additional arginines in the HA cleavage site, PEK<B>RR</B>TR/G, forming an MBCS-like motif. Quail/CA12 is a reassortant virus with the HA and neuraminidase (NA) gene most similar to a duck-isolated H4N2 virus, PD/CA06 with a monobasic HA cleavage site. Quail/CA12 required exogenous trypsin for efficient growth in culture and caused no clinical illness in infected chickens. Quail/CA12 had high binding preference for α2,6-linked sialic acids and showed higher replication and transmission ability in chickens and quails than PD/CA06. Although the H4N2 virus remained low pathogenic, these data suggests that the acquisition of MBCS in the field is not restricted to H5 or H7 subtypes.</P> <P><B>Highlights</B></P> <P> <UL> <LI> An H4N2 influenza virus with a multibasic cleavage site in the hemagglutinin protein was isolated from quails. </LI> <LI> This virus remained lowly pathogenic in chickens and required trypsin for <I>in vitro</I> growth. </LI> <LI> This virus showed higher preference for mammalian-type sialic acid receptors. </LI> <LI> This virus transmitted better in chicken than a duck-origin H4N2 virus. </LI> </UL> </P>
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