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Current Researches in Modular Biofabrication: Tissue Building Blocks and Bioreactors
Zakhireh Solmaz,Mesgari-Shadi Ali,Barar Jaleh,Omidi Yadollah,Beygi-Khosrowshahi Younes,Adibkia Khosro 한국화학공학회 2024 Korean Journal of Chemical Engineering Vol.41 No.6
Modular tissue engineering (TE) is based on the design, fabrication, and arrangement of replicated microtissue constructs to generate functional tissues. The advantage of this strategy is to produce tissues that more closely mimic the complex structure of native tissues/organs. High-precision technologies such as microfl uidics, 3D bioprinting, and electrospinning, which support both cell- and scaff old-based biofabrication methods, are implemented in a bottom-up TE strategy. Bioreactors are used in the last step of the tissue production process. Packed bed perfusion bioreactors are widely applied in bottom-up tissue engineering due to their ability to control perfusion to tissues. Modeling and simulation software packages are used as powerful tools to predict the perfusion and fl ow distribution to the tissues and to design robust bioreactors. This review imparts on the recent advances in the fi eld of bottom-up TE process and provides comprehensive insights into the cell-based and scaff old-based strategies used for the biofabrication/assembly of tissue building blocks (BBs). Microfl uidic devices and 3D-bioprinting technology are mentioned as precise controlling tools in this regard, the promoted applications of which are swiftly growing.
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