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        SEMI-PRIME CLOSURE OPERATIONS ON BCK-ALGEBRA

        BORDBAR, HASHEM,ZAHEDI, MOHAMMAD MEHDI Korean Mathematical Society 2015 대한수학회논문집 Vol.30 No.4

        In this paper we study the (good) semi-prime closure operations on ideals of a BCK-algebra, lower BCK-semilattice, Noetherian BCK-algebra and meet quotient ideal and then we give several theorems that make different (good) semi-prime closure operations. Moreover by given some examples we show that the given different notions are independent together, for instance there is a semi-prime closure operation, which is not a good semi-prime. Finally by given the notion of "$c_f$-Max X", we prove that every member of "$c_f$-Max X" is a prime ideal. Also we conclude some more related results.

      • Evaluation of the Frequency of the IL-28 Polymorphism (rs8099917) in Patients with Chronic Hepatitis C Using Zip Nucleic Acid Probes, Kerman, Southeast of Iran

        Iranmanesh, Zahra,Mollaie, Hamid Reza,Arabzadeh, Seyed Alimohammad,Zahedi, Mohammad Javad,Fazlalipour, Mehdi,Ebrahimi, Saeede Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.5

        Polymorphisms in the region of the interleukin IL-28 gene on chromosome 19 have been related with clearance of hepatitis C virus (HCV), a major human pathogen responsible for chronic hepatitis, cirrhosis and hepatocellular carcinoma. About 3% of the world's population is infected with HCV. The long-term response to therapy is influenced by many host and viral factors, and recent evidence has indicated that some host genetic polymorphisms related to IL-28 are the most powerful predictors of virological response in patients with HCV. This study assessed frequency of the IL-28 polymorphism (rs8099917) in 50 patients (39 men and 11 women) with chronic hepatitis C using ZNA probe real time PCR new method. All patients were tested for genotype of HCV and the HCV viral load. In parallel, the levels of SGOT, SGPT and ALK enzymes were assessed. Treatment using Peg-interferon alpha with ribavirin was conducted for patients and subsequently samples were collected to detect any change in viral load or liver enzyme rates. The overall frequency of the TT allele is 74%, TG allele 20% and GG allele 6% and the percent of patients who had T allele was 84%. Clear reduction in viral load and liver enzymes was reported in patients with the T allele. Especially for genotype 1 which is relatively resistant to treatment, these alleles may have a role in this decline. In conclusion, we showed that IL-28 polymorphism rs8099917 strongly predicts virological response in HCV infection and that real-time PCR with Zip nucleic acid probes is a sensitive, specific and rapid detection method for detection of SNPs which will be essential for monitoring patients undergoing antiviral therapy.

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