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RISS 인기검색어
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- 저자 : Z.Tanee Fomum (검색결과 2 건)
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Diacylglycerol Acyltransferase-Inhibitory Compounds from Erythrina senegalensis
오원근,이철호,정미연,Long Cui,Z.Tanee Fomum,강종성,이현선 대한약학회 2009 Archives of Pharmacal Research Vol.32 No.1
Inhibition of acyl CoA:diacylglycerol acyltransferase (DGAT) is proposed to be a drug target for the treatment of obesity and type 2 diabetes. Bioassay-guided fractionation of the CH2Cl2-soluble extract of the stem bark of Erythrina senegalensis, using an in vitro DGAT enzyme assay, resulted in the isolation of eight known prenylflavonoids, 8-prenylleutone (1), auriculatin (2), erysenegalensein O (3), erysenegalensein D (4), erysenegalensein N (5), derrone (6), alpinumisoflavone (7), and 6,8-diprenylgenistein (8). Compounds 1, 2-4, 6, and 8 inhibited DGAT activity, with IC50 values ranging from 1.1 ± 0.3 to 15.1 ± 1.1 μg/mL. On the basis of the data obtained, we propose isoflavonoids with isoprenyl groups as a novel class of DGAT inhibitors.
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A New Erythrinan Alkaloid from the Seed of Erythrina addisoniae
Long Cui,Won Keun Oh,Phuong Thien Thuong,Z. Tanee Fomum 대한약학회 2009 Archives of Pharmacal Research Vol.32 No.3
Phytochemical study on the EtOAc extract of the seed of Erythrina addisoniae (Leguminosae) resulted in the isolation of a new erythrinan alkaloid, erysovine-N-oxide (1), along with eight known alkaloids, erysosalvinone (2), erysodine (3), 1H-indole-3-propanamide (4), glucoerysodine (5), erysotrine (6), erysovine (7), erythraline (8) and erysopine (9). Their chemical structures were identified on the basis of physicochemical and spectroscopic analyses.
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