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Kaoru Ichikawa,Wen-Chang Yang,Akihiko Morimoto,Yutaka Yoshikawa,Shigeo Sugitani,Wen-Shan Chiang,Jian-Wu Lai,En Yu Liang,Cho-Teng Liu,Chang-Wei Lee,Kei Yufu,Moeto Kyushima,Satoshi Fujii,Tomoharu Senju 한국해양과학기술원 2013 Ocean science journal Vol.48 No.1
Japanese and Taiwanese institutes have collaborated to obtain ocean radar data with significantly increased coverage in the upstream Kuroshio region. An international joint survey was conducted in June 2012, in which intensive in situ observations were performed within the radar coverage. Details of the joint survey are presented in this paper with brief descriptions of preliminary results on the surface and subsurface currents near and within the Kuroshio.
Conditional PTEN-deficient Mice as a Prostate Cancer Chemoprevention Model
Koike, Hiroyuki,Nozawa, Masahiro,De Velasco, Marco A,Kura, Yurie,Ando, Naomi,Fukushima, Emiko,Yamamoto, Yutaka,Hatanaka, Yuji,Yoshikawa, Kazuhiro,Nishio, Kazuto,Uemura, Hirotsugu Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.5
Background: We generated a mouse model of prostate cancer based on the adult-prostate-specific inactivation of phosphatase and tensin homolog (PTEN) using the Cre-loxP system. The potential of our mice as a useful animal model was examined by evaluating the chemopreventive efficacy of the anti-androgen, chlormadinone acetate (CMA). Materials and Methods: Six-week-old mice were treated subcutaneously with $50{\mu}g/g$ of CMA three times a week for 9 or 14 weeks and sacrificed at weeks 15 and 20. Macroscopic change of the entire genitourinary tract (GUT) and histologically evident prostate gland tumor development were evaluated. Proliferation and apoptosis status in the prostate were examined by immunohistochemistry. Results: CMA triggered significant shrinkage of not only the GUT but also prostate glands at 15 weeks compared to the control (p=0.017 and p=0.010, respectively), and the trend became more marked after a further five-weeks of treatment. The onset of prostate adenocarcinoma was not prevented but the proliferation of cancer cells was inhibited by CMA, which suggested the androgen axis is critical for cancer growth in these mice. Conclusions: Conditional PTEN-deficient mice are useful as a preclinical model for chemoprevention studies and serve as a valuable tool for the future screening of potential chemopreventive agents.