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Brine Shrimp Lethality of the Compounds from Phryma leptostachya L.
이상명,ByungSunMin,YungHeeKho 대한약학회 2002 Archives of Pharmacal Research Vol.25 No.5
Brine shrimp assay-guided fractionation and isolation of the EtOAc soluble fraction of Phryma leptostachya L. (Phrymacaceae) gave two active compounds, phrymarolin II (1) and ursolic acid (2), which were identified by physicochemical and spectroscopic methods. Compound 1 exhibited potent lethality with LD50 value of 0.0013 mg/ml, whereas 2 showed moderate lethality with LD50 value of 27.0 mg/ml against brine shrimp. The cytotoxic activities of 1 and 2 were also evaluated against one murine and five human cancer cell lines employing the sulforhodamin B (SRB) method. Compound 2 exhibited cytotoxic activity against L1210 and SKMEL- 2 cells with ED50 values of 3.70 and 9.27 mg/ml, respectively, whereas 1 was devoid of any cytotoxic activity against all cancer cells tested.