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Effects of Eucommiae Cortex on Osteoblast-like Cell Proliferation and Osteoclast Inhibition
Ha, Hyek-Yung,Ho, Jinn-Yung,Shin, Sun-Mi,Kim, Hye-Jin,Koo, Sung-Ja,Kim, In-Ho,Kim, Chung-Sook The Pharmaceutical Society of Korea 2003 Archives of Pharmacal Research Vol.26 No.11
Methanol extract (MeOH), n-hexane (Hx), chloroform ($CHCl_3$), ethyl acetate (EA), butanol (BuOH) and aqueous ($H_2O$) fractions of Eucommiae Cortex including geniposidic acid (GA), geniposide (GP) and aucubin (AU) were tested for their therapeutic efficacy on osteoporosis. The contents of GA, GP and AU in the cortex and leaf of Eucommia ulmoides Oliver were quantified by HPLC. The effect of Eucommiae Cortex on the induction of growth hormone (GH) release was studied by using rat pituitary cells. The proliferation of osteoblast-like cells increased by herbal extracts was assayed using a tetrazolium (MTT), alkaline phosphatase (ALP) activity, and [$^3H$]-proline incorporation assays. The inhibition of osteoclast was studied by using the coculture of mouse bone marrow cells and ST-2 cells. As a result, the GA, GP and AU were present in the cortex more than in the leaf of E. ulmoides Oliver. The MeOH (1mg/mL), Hx, $CHCl_3$ and EA fractions (each 20 $\mu$ g/mL) had potent induction of GH release. The $CHCl_3$ exhibited the potent proliferation of osteoblasts. The AU, GP and GA were increased proliferation of osteoblasts. In addition, GA ($IC_{50}: 4.43{\times}10^{-7}$M), AU and GP were significantly inhibited proliferation of osteoclast. In summary, it is thought that the components in a part of the fractions of Eucommiae Cortex participate in each step of mechanism for activating osteoblast to facilitate osteogenesis, and suppress osteoclast activity to inhibit osteolysis.
On uniform convergence theorems for the interior integral
임동일,Yung-Jinn Kim 충청수학회 2006 충청수학회지 Vol.19 No.4
In this paper, we introduce interior integral and prove uniform convergence theorems for the interior integral.
A Uniform Convergence Theorem for Approximate Henstock-Stieltjes Integral
임성모,Yung-Jinn Kim,임동일 대한수학회 2004 대한수학회보 Vol.41 No.2
In this paper, we introduce, for each approximate distributiontilt of [a,b], the approximate Henstock-Stieltjes integralwith value in Banach spaces. The Henstock integral is a specialcase of this where tilt={(tau,[a,b]): tauin[a,b]}. Thisnew concept generalizes Henstock integral and abstractPerron-Stieltjes integral. We establish a uniform convergencetheorem for approximate Henstock-Stieltjes integral, which is animprovement of the uniform convergence theorem forPerron-Stieltjes integral by Schwabik [3].
ON UNIFORM CONVERGENCE THEOREMS FOR THE INTERIOR INTEGRAL
Rim, Dong-Il,Kim, Yung-Jinn 충청수학회 2006 충청수학회지 Vol.19 No.4
In this paper, we introduce interior integral and prove uniform convergence theorems for the interior integral.
THE MCSHANE INTEGRAL OF BANACH SPACE-VALUED FUNCTIONS
Rim, Dong-Il,Kim, Yung-Jinn 충청수학회 2004 충청수학회지 Vol.17 No.2
In this paper, we investigate the relations between the McShane and Pettis integrals.
A UNIFORM CONVERGENCE THEOREM FOR APPROXIMATE HENSTOCK-STIELTJES INTEGRAL
Im, Sung-Mo,Kim, Yung-Jinn,Rim, Dong-Il Korean Mathematical Society 2004 대한수학회보 Vol.41 No.2
In this paper, we introduce, for each approximate distribution $\~{T}$ of [a, b], the approximate Henstock-Stieltjes integral with value in Banach spaces. The Henstock integral is a special case of this where $\~{T}\;=\;\{(\tau,\;[a,\;b])\;:\;{\tau}\;{\in}\;[a,\;b]\}$. This new concept generalizes Henstock integral and abstract Perron-Stieltjes integral. We establish a uniform convergence theorem for approximate Henstock-Stieltjes integral, which is an improvement of the uniform convergence theorem for Perron-Stieltjes integral by Schwabik [3].
ON UNIFORM CONVERGENCE THEOREMS FOR THE INTERIOR INTEGRAL
Dong-Il Rim,Yung-Jinn Kim 충청수학회 2006 충청수학회지 Vol.19 No.4
In this paper, we introduce interior integral and prove uniform convergence theorems for the interior integral.