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LPS로 자극한 RAW 264.7 세포에서 중국 연변에 자생하는 약용 식물 에탄올 추출물의 항염증 효과 연구
박예진 ( Yea-jin Park ),서종환 ( Jong-hwan Seo ),길태영 ( Tae-young Gil ),천세윤 ( Se-yun Cheon ),박인철 ( Ren-zhe Piao ),이상우 ( Sang-woo Lee ),차윤엽 ( Yun-yeop Cha ),안효진 ( Hyo-jin An ) 대한본초학회 2018 大韓本草學會誌 Vol.33 No.6
Objectives : This study was fulfilled to investigate nominee materials as anti-inflammatory agent from ethanol extract of Chinese medicinal plants in Yanjin. Among the 20 candidates, we selected most effective one, the ethanol extract of Cicuta virosa L. (CVL). The mechanism underlying the anti-inflammatory effects of CVL is not clearly identified as yet. Accordingly, we clarified the anti-inflammatory effects of CVL and its underlying molecular mechanisms in LPS-stimulated RAW 264.7 macrophages. Methods : RAW264.7 macrophages were incubated with CVL (12.5, 25, or 50 μM) and/or lipopolysaccharide (LPS) (1 ㎍/㎖). Cytotoxicity was determined using a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide assay and the level of nitric oxide (NO) production was measured with Griess reagent. The prostaglandin E2 (PGE2) production was measured with enzyme immunoassay kits and the protein expression of inducible nitric oxide synthase (iNOS) was determined using Western blot analysis. Results : Among the 20 ethanol extract of Chinese medicinal plants of Yanjin tested, CVL significantly reduced the production of NO in a dose-dependent manner via inhibition the protein expressions of iNOS without cytotoxicity on the LPS-stimulated RAW 264.7 macrophages. In addition, CVL also effectively declined the production of PGE2 in LPS-simulated RAW 264.7 macrophages. Conclusions : Taken together, these data presented in this study demonstrate that CVL possesses anti- inflammatory activity by suppressing the production of pro-inflammatory mediators NO and PGE<sub>2</sub>, and pro- inflammatory protein iNOS expression in LPS-stimulated RAW 264.7 macrophages.
진병로,안인철,이윤이,길홍량 충남대학교 의과대학 지역사회의학연구소 1999 충남의대잡지 Vol.26 No.1
Congenital heart disease is the most common congenital malformation and its incidence is 8/1000 live birth, and contributes to significant perinatal morbidities and mortalities. With the advancement of echocardiogrphic equipment and technique, it is enable to detect the heart anomalies in utero. We performed 94 fetal (93 mothers) echocardiographic examinaton. 10 confirmed and 3 unconfirmed cardiac anomalies were identified. The common cardiac anomalies were ventricular septal defect(4), tetralogy of Fallot(2), and tricuspid valve regurgitation(2). The common indications of fetal echocardiography were as follows: family history of congenital heart disease(26), suspection by obstericians(24), fetal arrhythmia(13), and other organ anomaly(7). But the relative yield of indication were; suspected by obstericians 33.3%, other organ anomaly 14.3%, family history of congenital heart disease 7.6%, and fetal arrhythmia 7.6%. The false positive result was only 1 case of ventricular septal defect, which was normal in postnatal examination. The mean maternal age was 27years 5months in confirmed cases and 25years 5month s in unconfirmed cases. The fetal echocardiographic study for cardiac anomalies is reliable and accurate method in selected indicated groups, but systematic approach for screening method and identified cardiac anomalies would be needed.
Compact Wideband Open-End Slot Antenna With Inherent Matching
Zhe-Jun Jin,Tae-Yeoul Yun IEEE 2014 IEEE antennas and wireless propagation letters Vol.13 No.-
<P>A compact wideband open-end slot antenna is proposed for DCS, PCS, UMTS, WLAN, and WiMAX band applications. The antenna is composed of an open-ended slot and a central line within the slot. The open-end slot decreases the antenna size in half, compared to a conventional slot-ring antenna. Furthermore, the narrowed slot and central line miniaturize the antenna and obtain wideband performance using the inherent impedance-matching network of the central line. The proposed antenna obtained an omnidirectional radiation pattern with an antenna gain of larger than 1 dBi and an antenna efficiency of greater than 50% over 1710-3660 MHz.</P>
안봉운 ( Feng Yun An ),현영남 ( Yong Nan Xuan ),안영희 ( Young Hee Ahn ),김미란 ( Mei Lan Jin ),요점춘 ( Zhan Chun Yao ),양금화 ( Jin Hua Liang ),주청선 ( Qing Xian Zhou ),렴성철 ( Cheng Zhe Lian ),황빙군 ( Bing Jun Huang ),소보군 한국녹지환경디자인학회 2008 녹지환경학회지 Vol.4 No.2
Lonicera caerulea L. var. edulis Turcz et Herd. with great nutrient and commercial edible value, is a kind of wild berry resource in regions of Changbai Moutains, China. Systematic cultivation technology for its large-scale production is developed and formation of cultivated land with area of 150 hectares is established. With high-yield technology, the production yield can be increased by twice. Systematic cultivation technology and establishment of technology demonstration garden lay the foundation for construction of production base and large-scale production of Lonicera caerulea L. var. edulis Turcz et Herd.
( Chao Zhao ),( Yun Jin Deng ),( Xing Aa Wang ),( Qiu Zhe Li ),( Yi Fan Huang ),( Bin Liu ) 한국미생물 · 생명공학회 2014 Journal of microbiology and biotechnology Vol.24 No.9
In order to obtain the cellulolytic bacterial consortia, sediments from Great Basin hot springs (Nevada, USA) were sampled and enriched with cellulosic biomass as the sole carbon source. The bacterial composition of the resulting anaerobic ethanol-producing celluloytic bacterial consortium, named SV79, was analyzed. With methods of the full-length 16S rRNA librarybased analysis and denaturing gradient gel electrophoresis, 21 bacteria belonging to eight genera were detected from this consortium. Clones with closest relation to the genera Acetivibrio, Clostridium, Cellulosilyticum, Ruminococcus, and Sporomusa were predominant. The cellulase activities and ethanol productions of consortium SV79 using different agricultural residues (sugarcane bagasse and spent mushroom substrate) and energy crops (Spartina anglica, Miscanthus floridulus, and Pennisetum sinese Roxb) were studied. During cultivation, consortium SV79 produced the maximum filter paper activity (FPase, 9.41 U/ml), carboxymethylcellulase activity (CMCase, 6.35 U/ml), and xylanase activity (4.28 U/ml) with sugarcane bagasse, spent mushroom substrate, and S. anglica, respectively. The ethanol production using M. floridulus as substrate was up to 2.63 mM ethanol/g using gas chromatography analysis. It has high potential to be a new candidate for producing ethanol with cellulosic biomass under anoxic conditions in natural environments.
Sun, Xian-Yu,Jin, Yun-Zhe,Li, Fu-Nan,Li, Gao,Chai, Kyu-Yun,Quan, Zhe-Shan The Pharmaceutical Society of Korea 2006 Archives of Pharmacal Research Vol.29 No.12
A series of 8-alkoxy-4,5-dihydro-[1,2,4]triazole[4,3-a]quinoline-1-one derivatives were synthesized using 7-hydroxy-3,4-dihydro-2(1H)-quinolone as the starting material. Their anticonvulsant activities were evaluated by the maximal electroshock test (MES) and the subcutaneous pentylenetetrazole test (sc-PTZ), and their neurotoxicities were measured by the rotarod neurotoxicity test (Tox). The tests demonstrated that 8-hexyloxy-4,5-dihydro-[1.2.4]triazole[4.3-a]quinoline-1-one (4e) and 8-heptyloxy-4,5-dihydro-[1,2,4]triazole[4, 3-a]quinoline-1-one (4f) were the most potent anticonvulsants, with 4e having $ED_{50}$ values of 17.17 mg/kg and 24.55 mg/kg and protective index ($PI=TD_{50}/ED_{50}$) values of 41.9 and 29.3 in the MES and sc-PTZ tests, respectively, and 4f having $ED_{50}$ values of 19.7 mg/kg and 21.2 mg/kg and PI values of 36.5 and 33.9 in the MES and sc-PTZ tests, respectively. The PI values of 4e and 4f were many fold better than that of the marketed drugs phenytoin, carbamazepine, phenobarbital and valproate, which have PI values in the range of 1.6-8.1 in the MES test and <0.22-5.2 in the sc-PTZ test. Structure-activity relationships were also discussed.
Su Tong,Zhang Zhe,Chen Yu,Wang Yun,Li Yumei,Xu Min,Wang Jian,Li Jing,Tian Xinping,Jin Zhengyu 대한영상의학회 2024 Korean Journal of Radiology Vol.25 No.4
Objective: To evaluate the image quality of novel dark-blood computed tomography angiography (CTA) imaging combined with deep learning reconstruction (DLR) compared to delayed-phase CTA images with hybrid iterative reconstruction (HIR), to visualize the cervical artery wall in patients with Takayasu arteritis (TAK). Materials and Methods: This prospective study continuously recruited 53 patients with TAK (mean age: 33.8 ± 10.2 years; 49 females) between January and July 2022 who underwent head-neck CTA scans. The arterial- and delayed-phase images were reconstructed using HIR and DLR. Subtracted images of the arterial-phase from the delayed-phase were then added to the original delayed-phase using a denoising filter to generate the final-dark-blood images. Qualitative image quality scores and quantitative parameters were obtained and compared among the three groups of images: Delayed-HIR, Dark-blood-HIR, and Dark-blood-DLR. Results: Compared to Delayed-HIR, Dark-blood-HIR images demonstrated higher qualitative scores in terms of vascular wall visualization and diagnostic confidence index (all P < 0.001). These qualitative scores further improved after applying DLR (Dark-blood-DLR compared to Dark-blood-HIR, all P < 0.001). Dark-blood DLR also showed higher scores for overall image noise than Dark-blood-HIR (P < 0.001). In the quantitative analysis, the contrast-to-noise ratio (CNR) values between the vessel wall and lumen for the bilateral common carotid arteries and brachiocephalic trunk were significantly higher on Darkblood- HIR images than on Delayed-HIR images (all P < 0.05). The CNR values were significantly higher for Dark-blood-DLR than for Dark-blood-HIR in all cervical arteries (all P < 0.001). Conclusion: Compared with Delayed-HIR CTA, the dark-blood method combined with DLR improved CTA image quality and enhanced visualization of the cervical artery wall in patients with TAK.