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Kim, Young-Ho,Yeo, Woon-Hyung,Yun, Bong-Sik,Kim, Young-Sook,Lee, Sang-Jun,Yoo, Ik-Dong,Kim, Kab-Sig,Park, Eun-Kyung,Lee, Jong-Chull The Korean Society of Plant Pathology 2002 Plant Pathology Journal Vol.18 No.1
Two peptaibol antibiotics, peptavirins A and B, which exhibited strong inhibitory effect against Tobacco mosaic vials (TMV) infection, were isolated from steam-cooked rice culture of Apiocrea sp.14T. The peptavirins were identified as new derivatives of chrysospermins, which are 19-mer and have been reported to be produced in a fungal isolate. The physicochemical properties of the peptavirins were mostly identical with chrysospermins A through D except for the UV absorption spectrum. The peptavirins inhibited the growths of the Grampositive bacteria tested, including the plant pathogenic bacterium, Corynebacterium lilium, and the fungus, Aspergillus niger. Peptavirin A was somewhat cytotoxic to cancer cell lines, especially K562 (leukemia) and UACC 62 (melanoma), whereas peptavirin B only exhibited slight cytotoxicity.
Joo Won Park,Jeong Min Yun,이은성,윤유석,Kab Sig Kim,오영택,오경택 대한약학회 2013 Archives of Pharmacal Research Vol.36 No.11
While the number and diversity of lead compoundshas increased with the development of sciencetechnologies, ca. 90 % of new chemical entities underdevelopment have shown low aqueous solubility, classifiedas class II or IV of the biopharmaceutics classificationsystem (BCS). The low aqueous solubility hinders theirclinical translations due to low bioavailability and dissolution-limited absorption of orally-administered drugs. Several technologies have been employed to improve thesolubility of poorly water-soluble drugs. In this paper, anew method of nanoparticulation using fat and a supercriticalfluid (NUFS) for the formulation of hydrophobicdrugs was applied to solve the low solubility problem. A typical BCS class II drug, itraconazole, was selected andformulated with hydroxypropyl methylcellulose, emulsification,and anticoagulating agents for NUFS. The nonsphericalitraconazole nanoparticles prepared by NUFSwere *300–500 nm in size with a *15-fold improveddissolution rate compared to non-nanoparticles of itraconazole(i.e., raw itraconazole). In addition, a high drugcontent of *46 % by weight and a drug loading efficiencygreater than 85 % were achieved. Therefore, the newtechnology for nano-platforms could be a promising solutionfor solubilization of poorly water-soluble drugs,resulting in improved bioavailability.
Hong Suck-Ju,Ha Ok-Nam,Lee Kyu-Tae,Ha Kyung-Soo,Jeong Song-Tae,Hong Seong-In,Yun Kab-Sig,Kim Yang-Hyun,Kwon Il-Wook,Lee Jong-In The Society of Air-Conditioning and Refrigerating 2006 International Journal Of Air-Conditioning and Refr Vol.14 No.1
Because the usage of CFC and HCFC based refrigerants are restricted due to the depletion of ozone layer, the $NH_3$ gas, in the experiment is evaluated to the performance characteristics for the superheat control to improve the energy efficiency. The experiment is carried out about the condensing pressure of refrigeration system from 1,500 kPa to 1,600 kPa through the degree of superheat from 0 to $10^{\circ}C$ at each condensing pressure. As a result, in the case of shell and tube type of heat exchanger, the COP is more efficient than other cases at the degree of superheat $1^{\circ}C$ at each condensing pressure. In the case of shell and disk type of heat exchanger, the COP is the most efficient at the degree of superheat 0.
Suck-Ju Hong,Ok-Nam Ha,Kyu-Tae Lee,Kyung-Soo Ha,Song-Tae Jeong,Seong-In Hong,Kab-Sig Yun,Yang-Hyun Kim,Il-Wook Kwon,Jong-In Lee 대한설비공학회 2006 International Journal Of Air-Conditioning and Refr Vol.14 No.1
Because the usage of CFC and HCFC based refrigerants are restricted due to the depletion of ozone layer, the NH₃ gas, in the experiment is evaluated to the performance characteristics for the superheat control to improve the energy efficiency. The experiment is carried out about the condensing pressure of refrigeration system from 1,500㎪ to 1,600㎪ through the degree of superheat from 0 to 10℃ at each condensing pressure. As a result, in the case of shell and tube type of heat exchanger, the COP is more efficient than other cases at the degree of superheat 1℃ at each condensing pressure. In the case of shell and disk type of heat exchanger, the COP is the most efficient at the degree of superheat 0.
Choi, Jinhyang,Ko, Eunjung,Chung, Hye-Kyung,Lee, Jae Hee,Ju, Eun Jin,Lim, Hyun Kyung,Park, Intae,Kim, Kab-Sig,Lee, Joo-Hwan,Son, Woo-Chan,Lee, Jung Shin,Jung, Joohee,Jeong, Seong-Yun,Song, Si Yeol,Cho Dove Medical Press 2015 INTERNATIONAL JOURNAL OF NANOMEDICINE Vol.10 No.-
<P>Nanoparticulation of insoluble drugs improves dissolution rate, resulting in increased bioavailability that leads to increased stability, better efficacy, and reduced toxicity of drugs. Docetaxel (DTX), under the trade name Taxotere™, is one of the representative anticancer chemotherapeutic agents of this era. However, this highly lipophilic and insoluble drug has many adverse effects. Our novel and widely applicable nanoparticulation using fat and supercritical fluid (NUFS™) technology enabled successful nanoscale particulation of DTX (Nufs-DTX). Nufs-DTX showed enhanced dissolution rate and increased aqueous stability in water. After confirming the preserved mechanism of action of DTX, which targets microtubules, we showed that Nufs-DTX exhibited similar effects in proliferation and clonogenic assays using A549 cells. Interestingly, we observed that Nufs-DTX had a greater in vivo tumor growth delay effect on an A549 xenograft model than Taxotere™, which was in agreement with the improved drug accumulation in tumors according to the biodistribution result, and was caused by the enhanced permeability and retention (EPR) effect. Although both Nufs-DTX and Taxotere™ showed negative results for our administration dose in the hematologic toxicity test, Nufs-DTX showed much less toxicity than Taxotere™ in edema, paralysis, and paw-withdrawal latency on a hot plate analysis that are regarded as indicators of fluid retention, peripheral neuropathy, and thermal threshold, respectively, for toxicological tests. In summary, compared with Taxotere™, Nufs-DTX, which was generated by our new platform technology using lipid, supercritical fluid, and carbon dioxide (CO<SUB>2</SUB>), maintained its biochemical properties as a cytotoxic agent and had better tumor targeting ability, better in vivo therapeutic effect, and less toxicity, thereby overcoming the current hurdles of traditional drugs.</P>