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Sejin Oh,Jaeyoon Lee,Yukang Kim,Kwon-Ho Song,Eunho Cho,Minsung Kim,Heejae Jung,김태우 대한면역학회 2020 Immune Network Vol.20 No.1
Cancer immunotherapy, in the form of vaccination, adoptive cellular transfer, or immune checkpoint inhibitors, has emerged as a promising practice within the field of oncology. However, despite the developing field's potential to revolutionize cancer treatment, the presence of immunotherapeutic-resistant tumor cells in many patients present a challenge and limitation to these immunotherapies. These cells not only indicate immunotherapeutic resistance, but also show multi-modal resistance to conventional therapies, abnormal metabolism, stemness, and metastasis. How can immunotherapeutic-resistant tumor cells render multi-malignant phenotypes? We reasoned that the immune-refractory phenotype could be associated with multi-malignant phenotypes and that these phenotypes are linked together by a factor that acts as the master regulator. In this review, we discussed the role of the embryonic transcription factor NANOG as a crucial master regulator we named “common factor” in multi-malignant phenotypes and presented strategies to overcome multi-malignancy in immunotherapeutic-resistant cancer by restraining the NANOG-mediated multi-malignant signaling axis. Strategies that blunt the NANOG axis could improve the clinical management of therapy-refractory cancer.
Enhancing Physiochemical Properties of Chitosan Films Through Photo-crosslinking by Riboflavin
Shengyu Zhu,Jiliu Pei,Yukang Song,Yu Liu,Feng Xue,Xiaohui Xiong,Chen Li 한국섬유공학회 2022 Fibers and polymers Vol.23 No.10
This study aimed to improve the physicochemical properties of chitosan (CS) film by riboflavin (RF)-inducedcross-linking under ultraviolet (UV) light for different times (0, 2, 4, 6 h). It was found that the water vapor resistance, tensilestrength, optical property, and thermal stability of the film were significantly enhanced under RF-induced photo-crosslinking,especially when illuminated for 6 h. Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD) verified themolecular bonding of CS and RF, as well as scanning electron microscope (SEM) showed a tighter and more uniform filmstructure was formed through UV crosslinking. Thus, the CS-RF films have the potential to replace petrochemical materialsas a novel type of environmentally friendly packaging material.