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RISS 인기검색어
- 검색키워드
- 저자 : Yuejin Yuan (검색결과 6 건)
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Libin Tan,Yuejin Yuan 대한기계학회 2023 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.37 No.1
The comprehensive performance evaluation procedure and overall performance evaluation indices for the four cylinder engine cooling systems are proposed in this work and the four cylinder engine cooling system with two different flow patterns are investigated. Coolant velocity distributions of nose bridge area sections of cylinder head water jacket and plane section of cylinder block water jacket in series flow pattern cooling system meet the coolant flow velocity requirements of 1.5 m/s in high-temperature area. Coolant velocity distributions of water jacket in parallel flow pattern cooling system is relatively lower and not meet the velocity requirements of 1.5 m/s. Through the improvement of pump performance, the system coolant flowrate in parallel flow pattern cooling system can be increased to 90 L/min. After velocity uniformity improvement of water jacket, the coolant velocity distributions in parallel flow cooling system become more uniform. Coolant velocity and heat transfer coefficient of high temperature area both meet the design requirements of coolant velocity 1.5 m/s and heat transfer coefficients of 5000 W/(m 2 ·K). The cooling performance for the engine with parallel flow pattern cooling system is significantly improved and meets the cooling design requirements.
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Libin Tan,Yuejin Yuan 대한기계학회 2023 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.37 No.8
Aiming at improving the cooling of motor annular water jacket, the effects of different water jacket designs and pump rotation speed and epoxy resin filling on the flow field characteristics and motor temperature distribution were studied. Results show that uneven flow distribution leads to high temperature of motor coil and large temperature gradient. The optimized water jacket has better flow, uniform flow distribution of long and short paths, higher utilization rate of coolant, and the coil temperature is 2 °C lower than that of original model. On the basis of optimized water jacket, when epoxy resin filling methodology and pump rotation speed increased to 5000 r/min are applied, the coil temperature can be reduced by 16 °C compared with the original model. From the cooling performance optimization results in current case, the improvement order from the smallest to the biggest is the optimization of motor water jacket flow field, optimization of motor water jacket system flow rate, and the epoxy resin filling. To meet the cooling demands of motor, the comprehensive effects from the aspects of reducing coolant system resistance, increasing pump speed, epoxy resin filling and other effective technologies are ought to be considered for all case studies.
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Oncogenic super-enhancer formation in tumorigenesis and its molecular mechanisms
Qunying Jia,Shuhua Chen,Yuan Tan,Yuejin Li,Faqing Tang 생화학분자생물학회 2020 Experimental and molecular medicine Vol.52 No.-
Super-enhancers (SEs) consist of a cluster of many enhancers bound to a great number of transcription factors. They are critical cis-regulatory elements that determine the identity of various human cell types. During tumorigenesis, DNA mutations and indels, chromosomal rearrangements, three-dimensional chromatin structural changes, and viral infections mediate oncogenic SE activation, and activated SEs have been found to regulate the expression of oncogenic genes. Inhibition specifically targeted to oncogenic SE assembly and activation provides a novel powerful therapeutic strategy for various cancers. In this paper, we first introduce the current understanding of oncogenic SE assembly and activation and then summarize the pathogenic factors and mechanism of oncogenic SE activation. Next, we elaborate on the oncogenic functions of SEs in cancers and the application of SEs as therapeutic targets. Finally, we turn our focus to the use of SEs in basic research and clinical trials.
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Dong Wang,Libin Tan,Yuejin Yuan,Yuming Lu 대한기계학회 2023 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.37 No.10
Airflow velocity uniformity in material drying room used in steam blanching and hot-air vacuum drying equipment is crucial for obtaining a good drying quality of fruits and vegetables. To analyze the airflow velocity uniformity and give the optimization design for improving the airflow uniformity, CFD method is used for the flow field analysis of material drying room and the velocity non-uniformity coefficient is used as the evaluation indicator for the velocity uniformity. Results show that the airflow velocity distribution in the material drying room at the original inlet airflow distribution chamber is relatively uneven and the airflow velocity nonuniformity coefficient in drying area is 34 %. For reducing the airflow velocity non-uniformity, the airflow velocity distribution of three structural modification directions with 12 designs in total are analyzed and compared. The minimum airflow velocity non-uniformity coefficient for adding a spoiler model, reducing the closed end width and adding nozzle baffles are 17.1 %, 30.2 %, 10.4 %, respectively. Through comparison, adding the nozzle baffle with a width of 11 mm at the rear end of each nozzle outlet is considered as the optimal designs to conduct the experimental validation. Experimental validation results shows the the relative error between the simulated value and the measured value is within 10 %, proving that the CFD prediction results is reliable and the research results can give a theoretical reference for the designers to evaluate and optimize the structure of inlet airflow distribution chamber for improving the airflow uniformity in drying area.
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