Expression of Proteasome Activator REGγ in Human Laryngeal Carcinoma and Associations with Tumor Suppressor Proteins

Li, Li-Ping,Cheng, Wei-Bo,Li, Hong,Li, Wen,Yang, Hui,Wen, Ding-Hou,Tang, Yue-Di Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.6

The functional significance of the proteasome activator $REG{\gamma}$ in the regulation of cell proliferation and apoptosis has been recognized. However, pathological contributions to tumor development remain to be elucidated. Both oncogenic proteins and tumor suppressors are targeted by $REG{\gamma}$ for proteasomal degradation. It has been proposed that the role of the $REG{\gamma}$ in the pathogenesis of cancer is cell- and context-specific. In this study, we aimed to explore the potential involvement of $REG{\gamma}$ in laryngeal carcinomas, comparing protein expression in tumor and adjacent tissues by immunohistochemical staining and Western blot analysis. We also characterized the correlation between the expression of $REG{\gamma}$ and the previously identified substrates p53 and p21. We showed that $REG{\gamma}$ was abnormally highly expressed in cancer tissues. Statistical analysis revealed that there was a positive relationship between the level of $REG{\gamma}$ and the expression of p53 and p21. Our study suggests that $REG{\gamma}$ overexpression can facilitate the growth of laryngeal cancer cells.

Study on Enterprise Value and Asset Structure Optimization of the Iron and Steel Industry in China under Carbon Reduction Strategy

Hong Hong ZHU,Yue Yao SUN,Jin Bao LI 한국유통과학회 2022 The Journal of Asian Finance, Economics and Busine Vol.9 No.3

The iron and steel sector is caught between two worlds: “carbon reduction” and “development.” The goal of this study is to show that optimizing asset structure to boost intangible assets, particularly brand assets, is a viable strategy to achieve low-carbon development. This study uses panel data from 38 A-share companies in China’s iron and steel industry from 2010 to 2020, as well as World Brand Lab data, to create a comprehensive impact index of enterprise value from the standpoint of an asset structure optimization, and to test the impact of intangible assets and brand equity on enterprise value. The findings show that: the asset structure of iron and steel enterprises is closely related to enterprise value, implying that iron and steel industry development necessitates a transformation of quantity control and quality improvement; the proportion of intangible assets in the asset structure of iron and steel enterprises plays a positive and critical role in enterprise value under surplus conditions. The iron and steel industry begins to shift from tangible to intangible assets; there is heterogeneity in the iron and steel industry transformation. Given certain technological levels, the share of brand assets contributes significantly to the increase in enterprise value.

ZnO Nanowire Arrays on 3D Hierachical Graphene Foam: Biomarker Detection of Parkinson’s Disease

Yue, Hong Yan,Huang, Shuo,Chang, Jian,Heo, Chaejeong,Yao, Fei,Adhikari, Subash,Gunes, Fethullah,Liu, Li Chun,Lee, Tae Hoon,Oh, Eung Seok,Li, Bing,Zhang, Jian Jiao,Huy, Ta Quang,Luan, Nguyen Van,Lee, Y American Chemical Society 2014 ACS NANO Vol.8 No.2

<P>We report that vertically aligned ZnO nanowire arrays (ZnO NWAs) were fabricated on 3D graphene foam (GF) and used to selectively detect uric acid (UA), dopamine (DA), and ascorbic acid (AA) by a differential pulse voltammetry method. The optimized ZnO NWA/GF electrode provided a high surface area and high selectivity with a detection limit of 1 nM for UA and DA. The high selectivity in the oxidation potential was explained by the gap difference between the lowest unoccupied and highest occupied molecular orbitals of a biomolecule for a set of given electrodes. This method was further used to detect UA levels in the serum of patients with Parkinson’s disease (PD). The UA level was 25% lower in PD patients than in healthy individuals. This finding strongly implies that UA can be used as a biomarker for PD.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/ancac3/2014/ancac3.2014.8.issue-2/nn405961p/production/images/medium/nn-2013-05961p_0005.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/nn405961p'>ACS Electronic Supporting Info</A></P>

Electrical properties of Mg x Zn1−x O thin films deposited by using RF magnetron co-sputtering with ZnO and Mg0.3Zn0.7O targets

Yue, Li Li,Yang, Yi Da,Kim, Hong Seung,Jang, Nak Won,Yun, Young 한국물리학회 2016 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol. No.

<P>We successfully deposited hexagonal wurtzite Mg (x) Zn1-x O (0 a parts per thousand currency sign x a parts per thousand currency sign 0.18) films on Si substrates by using RF magnetron co-sputtering with ZnO and Mg0.3Zn0.7O targets. The Mg content was varied by controlling the RF power of the Mg0.3Zn0.7O target while the RF power of the ZnO target was fixed at 100 W. The electrical properties of the Mg (x) Zn1-x O films were investigated by using a transmission line model (TLM) with Ti/Au electrode and Hall effect measurements. The X-ray diffraction (XRD) results demonstrate that some Zn atoms can be replaced by Mg atoms in the Mg (x) Zn1-x O films. As the Mg content was increased from 0 at.% to 18 at.%, the resistivity of Mg (x) Zn1-x O films increased and the carrier concentration decreased from 1.17 x 10(19) cm(-3) to 1.17 x 10(17) cm(-3), which indicates a decrease in the number of oxygen vacancies. Meanwhile, the Hall mobility increased to 15.3 cm(2)/Vs. The electrical properties of Mg (x) Zn1-x O films were tuned by using the Mg content.</P>

ER81-shRNA Inhibits Growth of Triple-negative Human Breast Cancer Cell Line MDA-MB-231 In Vivo and in Vitro

Chen, Yue,Zou, Hong,Yang, Li-Ying,Li, Yuan,Wang, Li,Hao, Yan,Yang, Ju-Lun Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.5

The lack of effective treatment targets for triple-negative breast cancers make them unfitted for endocrine or HER2 targeted therapy, and their prognosis is poor. Transcription factor ER81, a downstream gene of the HER2, is highly expressed in breast cancer lines, breast atypical hyperplasia and primary breast cancers including triple-negative examples. However, whether and how ER81 affects breast cancer carcinogenesis have remained elusive. We here assessed influence on a triple-negative cell line. ER81-shRNA was employed to silence ER81 expression in the MDA-MB-231 cell line, and MTT, colony-forming assays, and flow cytometry were used to detect cell proliferation, colony-forming capability, cell cycle distribution, and cell apoptosis in vitro. MDA-MB-231 cells stably transfected with ER81-shRNA were inoculated into nude mice, and growth inhibition of the cells was observed in vivo. We found that ER81 mRNA and protein expression in MDA-MB-231 cells was noticeably reduced by ER81-shRNA, and that cell proliferation and clonality were decreased significantly. ER81-shRNA further increased cell apoptosis and the residence time in $G_0/G_1$ phase, while delaying tumor-formation and growth rate in nude mice. It is concluded that ER81 may play an important role in the progression of breast cancer and may be a potentially valuable target for therapy, especially for triple negative breast cancer.

Pellet injectors for EAST and KSTAR tokamaks

Vinyar, Igor,Hu, Jiansheng,Park, Soo-Hwan,Lukin, Alexander,Yao, Xinjia,Li, Changzheng,Chen, Yue,Reznichenko, Pavel,Kim, Hong-Tack Elsevier 2017 Fusion engineering and design Vol.124 No.-

<P><B>Abstract</B></P> <P>The paper presents high frequency pellet injectors developed for edge localized mode mitigation and plasma fuelling of the EAST and KSTAR tokamaks. Each pellet injector is able to inject solid deuterium or hydrogen pellets at steady state mode. Injectors consist of modules including screw extruder cooled by liquid helium and pneumatic punchers for pellet fabrication and acceleration which are optimized to reach maximal injection frequency for specified pellet parameters.</P> <P>The EAST pellet injector is capable of injecting 1.5mm diameter and 1.2–1.8mm length pellets at frequency up to 50Hz with velocities 200–250m/s using two injection modules working in an alternating mode at 25Hz each. Injection reliability over 90% has been confirmed during several cycles of continuous D2 pellet injection at 50Hz. The KSTAR pellet injector has been designed to inject 2mm size pellets at frequency up to 20Hz and velocity 200m/s. Due to improved design of pellet fabrication and acceleration system the world record in continuous injection of 20,164 deuterium pellets (Ø2.0×1.5mm) for 1039s at 20Hz with reliability 97% has been achieved.</P> <P><B>Highlights</B></P> <P> <UL> <LI> 50Hz and 20Hz pellet injectors have been developed for edge localized mode mitigation and steady state plasma fuelling of the EAST and KSTAR tokamaks. </LI> <LI> Innovative pellet fabrication systems have been designed to achieve world record in continuous pellet injection during 1039s at 20Hz with reliability 97%. </LI> <LI> Both pellet injectors have achieved ITER relevant characteristics of plasma fuelling and ELM control. </LI> </UL> </P>

Evaluating the electric property of different crystal faces and enhancing the Raman scattering of Cu2O microcrystal by depositing Ag on the surface

Hong Gao,Junying Zhang,Min Li,Kejia Liu,Dong Guo,Yue Zhang 한국물리학회 2013 Current Applied Physics Vol.13 No.5

The surface electric property of Cu2O microcrystal affects the interaction of facets with substance in the aqueous solution, and hence plays a key role in determining the photocatalytic activity. In this paper, the capability of Cu2O microcrystals with exclusive {111}, {110} or both lattice surfaces in reducing Agþ to Ag0were investigated. Ag particles selectively deposited on {111} surfaces of Cu2O, while not on {110} surfaces. The different behaviors of the two surfaces are mainly attributed to their different electric properties:negatively-charged {111} surfaces absorb Agþ ions while positively-charged {110} surfaces repel them. Raman scattering of Cu2O {111} surfaces was enhanced by the photo-deposition of Ag particles.

Depression and APOEε4 Status in Individuals with Subjective Cognitive Decline: A Meta-Analysis

Yue-ping Huang,Ju-jun Xue,Chao Li,Xi Chen,Hong-juan Fu,Teng Fei,Peng-xiang Bi 대한신경정신의학회 2020 PSYCHIATRY INVESTIGATION Vol.17 No.9

Objective To evaluate the associative role of depression and apolipoprotein E epsilon 4 allele (APOEε4) in subjective cognitive decline(SCD) and its progression to objective cognitive decline. Methods After literature search in electronic databases, studies were selected by following precise eligibility criteria. Meta-analyses were performed to examine the role of APOEε4 and depression in SCD or its progression to mild cognitive impairment (MCI) or dementia. Results APOEε4 positivity was not different between SCD and normal individuals but was significantly higher in individuals with SCD plus than in normal individuals [odds ratio: 2.39 (95% CI: 1.87, 3.05); p<0.00001] and in SCD converters than in non-converters [odds ratio: 5.19 (95% CI: 2.36, 11.42); p<0.00001]. Depression was significantly higher in individuals with SCD [standardized mean difference: 0.63 (0.45, 0.82); p<0.00001] and SCD plus [standardized mean difference: 0.83 (0.43, 1.22); p<0.0001] than in normal individuals. However, depression was not different between SCD and MCI or between SCD converters and non-converters. Age of SCD converters was higher than non-converters [mean difference: 2.95 years (0.58, 5.31)]. Conclusion Whereas APOEε4 positivity was higher in SCD plus and SCD converters, depression was higher in SCD and SCD plus but was not different between SCD and MCI.

Longitudinal Intrinsic Brain Activity Changes in Cirrhotic Patients before and One Month after Liver Transplantation

Yue Cheng,Li-Xiang Huang,Li Zhang,Ming Ma,Shuang-Shuang Xie,Qian Ji,Xiao-Dong Zhang,Gao-Yan Zhang,Xue-Ning Zhang,Hong-Yan Ni,Wen Shen 대한영상의학회 2017 Korean Journal of Radiology Vol.18 No.2

Objective: To evaluate the spontaneous brain activity alterations in liver transplantation (LT) recipients using resting-state functional MRI. Materials and Methods: Twenty cirrhotic patients as transplant candidates and 25 healthy controls (HCs) were included in this study. All patients repeated the MRI study one month after LT. Amplitude of low-frequency fluctuation (ALFF) values were compared between cirrhotic patients (both pre- and post-LT) and HCs as well as between the pre- and post-LT groups. The relationship between ALFF changes and venous blood ammonia levels and neuropsychological tests were investigated using Pearson’s correlation analysis. Results: In the cirrhotic patients, decreased ALFF in the vision-related regions (left lingual gyrus and calcarine), sensorimotor-related regions (left postcentral gyrus and middle cingulate cortex), and the default-mode network (bilateral precuneus and left inferior parietal lobule) were restored, and the increased ALFF in the temporal and frontal lobe improved in the early period after LT. The ALFF decreases persisted in the right supplementary motor area, inferior parietal lobule, and calcarine. The ALFF changes in the right precuneus were negatively correlated with changes in number connection test-A scores (r = 0.507, p < 0.05). Conclusion: LT improved spontaneous brain activity and the results for associated cognition tests. However, decreased ALFF in some areas persisted, and new-onset abnormal ALFF were possible, indicating that complete cognitive function recovery may need more time.

Business Process Adaptation Based on Process Variants

Hong Xia Li,Yu Yue Du 보안공학연구지원센터 2016 International Journal of Grid and Distributed Comp Vol.9 No.4

An extensional method for existing business processes is proposed to adapt new environments based on process variants in this paper. The core processes describing maximal commonalities of process variants are introduced according to inheritance relation. Then, extensional business processes are defined based on the core processes. The algorithms of the core processes and extensional business are given and proved. And the soundness of two kinds of processes is justified. An example shows that extensional business processes can adapt to the new environment better than the original process.