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Effect of P3HT passivation layer on triple cation organic-inorganic hybrid perovskite memristor
Wang Yucheng,Xiong Yuxuan,Wang Hongsu,Wu Xiang,Sha Jian,Shang Yueyang,Zhang Yongqi,Li Wei,Wang Shaoxi 한국물리학회 2023 Current Applied Physics Vol.47 No.-
Triple cation organic-inorganic hybrid perovskite (TCP) memristor is a novel candidate for artificial visual applications due to the integrating of recognition, storage, and computing. However, concerns remain regarding the moisture-induced degradation and thermal stability. Here, P3HT was deposited on the TCP film to optimize the memristor performance which showed better film surface quality and lower power consumption. When the thickness of the P3HT layer increases, the grain boundary of the TCP film was gradually filled, leading to the inhibition of the ions/vacancies drifting, and thus the device type was changed from digital to analog. Besides, various functions are demonstrated in TCP photoelectric memristor including excitatory postsynaptic current under optic and electric stimulations and spike rate-dependent plasticity, proving the great application prospects in numerical calculation and information perception.
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Yuan Zhang,Lufei Zhang,Sinan Lu,Yucheng Xiang,Cheng Zeng,Tianyu He,Yuan Ding,Weilin Wang 대한암학회 2021 Cancer Research and Treatment Vol.53 No.1
Purpose Intrahepatic cholangiocarcinoma (ICC) is one of the most common liver primary tumors but its treatments are limited. Bioinformatics showed that the expression level of long non-coding RNA cancer-associated susceptibility 15 gene (CASC15) is correlated with ICC progression, but its functional mechanism remains unclear. Materials and Methods Tissues from ICC patients, tumor and adjacent tissue, were used for detection of the expression of CASC15. Clinical data were also collected for clinicopathologic and survival analysis. Short interfering RNA and lentiviral short hairpin RNA were used to knock down CASC15 and PRDX2 expression in ICC cell lines, for the analysis of changes of cell function and xenografts. RNA-pulldown and RNA immunoprecipitation assays were used to detect RNA-binding protein, PRDX2. Male nude mice were used for ICC xenografts, and livers were collected after 4 weeks for immunohistochemistry. Results CASC15 is highly expressed in ICC tissues and is related to higher TNM stage. Knockdown of CASC15 in ICC cells reduced cell proliferation, migration, invasiveness and increased apoptosis, and G1/S block. PRDX2 bound to CASC15. Knockdown of CASC15 decreased PRDX2 expression which was rescued by the inhibition of proteasome formation. Downregulation of PRDX2 resulted in G1/S block, reduced ICC cell invasion. Downregulation of CASC15 inhibited phosphoinositide 3-kinase (PI3K)/AKT/c-Myc pathway through downregulating of PRDX2 and overexpressed PRDX2 rescued the block. CASC15 knockout in ICC xenografts suppressed tumor development in vivo, decreased the expression of PRDX2 and Ki67 and inhibited PI3K/AKT pathway. Conclusion CASC15 promotes ICC possibly by targeting PRDX2 via the PI3K/AKT pathway, indicating poor prognosis and high degree of malignancy of ICC.
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Wang Kang,Xi Ya,Zan Xiang,Zhu Dahuan,Luo Laima,Ding Rui,Wu Yucheng 한국원자력학회 2024 Nuclear Engineering and Technology Vol.56 No.6
A melting failure of W monoblock components of the upper divertor outer target in EAST occurred during the plasma campaigns in 2019. The failure characters and microstructure evolution of the failed W monoblock have been well investigated on one string (W436 string). Near the strike point region where heat flux density is highest, macroscopic cracks and severe surface damage such as dimensional change, melting and solidification are visible in several W monoblocks. At the same time, debonding, melting and migration of Cu/CuCrZr cooling tube components introduced fatal damage to the structure and function. The heat-induced microstructure evolution in the rest part has been examined via hardness tests and metallography. From the heat flux surface to the cooling tube, hardness increased gradually and the recrystallized grains could be found in the region with the highest temperature, while recrystallization grains also appear in some W monoblocks near the cooling tube area. The detailed microstructure has been investigated by metallography and EBSD. Such cases in EAST provide experiences on the extreme condition of accidental loss of coolant or higher discharge power in future devices.
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