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      • KCI등재

        Mechanical behavior of stud shear connectors embedded in HFRC

        Yu-Liang He,Xu-Dong Wu,Yiqiang Xiang,Yu-Hang Wang,Li-Si Liu,Zhi-Hai He 국제구조공학회 2017 Steel and Composite Structures, An International J Vol.24 No.2

        Hybrid-fiber reinforced concrete (HFRC) may provide much higher tensile and flexural strengths, tensile ductility, and flexural toughness than normal concrete (NC). HFRC slab has outstanding advantages for use as a composite bridge potential deck slab owing to higher tensile strength, ductility and crack resistance. However, there is little information on shear connector associated with HFRC slabs. To investigate the mechanical behavior of the stud shear connectors embedded in HFRC slab, 14 push-out tests (five batches) in HFRC and NC were conducted. It was found that the stud shear connector embedded in HFRC had a better ductility, higher stiffness and a slightly larger shear bearing capacity than those in NC. The experimentally obtained ultimate resistances of the stud shear connectors were also compared against the equations provided by GB50017 2003, ACI 318-112011, AISC 2011, AASHTO LRFD 2010, PCI 2004, and EN 1994-1-1 (2004), and an empirical equation to predict the ultimate shear connector resistance considering the effect of the HFRC slabs was proposed and validated by the experimental data. Curve fitting was performed to find fitting parameters for all tested specimens and idealized load-slip models were obtained for the specimens with HFRC slabs.

      • Analysis Of the Total Electrical Length Extremum Of TSSIR Using Lagrange Multipliers Method

        Wang Shan,Sun Yu,Wang Yao,Yu Yiqiang 보안공학연구지원센터 2016 International Journal of Grid and Distributed Comp Vol.9 No.1

        A systematic approach to determine the extreme value of total electrical length for tri-section stepped impedance resonator (TSSIR) is proposed in this paper. It utilizes the Lagrange multipliers method to search the extremum condition. Result demonstrates that the maximum resonator length of TSSIR is limited to triple that of the corresponding uniform impedance resonator (UIR). Spurious resonant frequency of λ/2 TSSIR is mainly analysized under the extremum condition (θ1≠θ2≠θ3). Through comparison between the proposed approach and previously assumed condition (θ1=θ2=θ3), the staircase discontinuity of transmission line can be reduced using the paper theory to achieve same harmonic ratio. Last, a simulated example is presented to verify correctness of the method. This paper aims to provide a theoretical basis and general guideline for the filter design using TSSIR.

      • KCI등재

        Impact of Refined Land Surface Properties on the Simulation of a Heavy Convective Rainfall Process in the Pearl River Delta Region, China

        Ming Chang,Shaofen Fan,Qi Fan,Weihua Chen,Yiqiang Zhang,Yu Wang,Xuemei Wang 한국기상학회 2014 Asia-Pacific Journal of Atmospheric Sciences Vol.50 No.5

        The location and occurrence time of convective rainfallshave attracted great public concern as they can lead to terribledisasters. However, the simulation results of convective rainfalls inthe Pearl River Delta region often show significant discrepanciesfrom the observations. One of the major causes lies in the inaccurategeographic distribution of land surface properties used in the modelsimulation of the heavy precipitation. In this study, we replaced thedefault soil and vegetation datasets of Weather Research andForecasting (WRF) model with two refined datasets, i.e. theGlobCover 2009 (GLC2009) land cover map and the HarmonizedWorld Soil Database (HWSD) soil texture, to investigate the impactof vegetation and soil on the rainfall patterns. The result showed thatthe simulation patterns of convective rainfalls obtained from thecoupled refined datasets are more consistent with the observationsthan those obtained from the default ones. By using the coupledrefined land surface datasets, the overlap ratio of high precipitationdistricts reached 36.3% with a variance of 28.5 km from theobserved maximum rainfall position, while those of the defaultUnited States Geological Survey (USGS) dataset and ModerateResolution Imaging Spectroradiometer (MODIS) dataset are 17.0%/32.8 km and 24.9%/49.0 km, respectively. The simulated totalrainfall amount and occurrence time using the coupled refineddatasets are the closest to the observed peak values. In addition, theHWSD soil data has improved the accuracy of the simulatedprecipitation amount, and the GLC2009 land cover data also didbetter in catching the early peak time.

      • KCI등재

        MiR-1224-5p modulates osteogenesis by coordinating osteoblast/osteoclast differentiation via the Rap1 signaling target ADCY2

        Hu Liangcong,Xie Xudong,Xue Hang,Wang Tiantian,Panayi Adriana C.,Lin Ze,Xiong Yuan,Cao Faqi,Yan Chengcheng,Chen Lang,Cheng Peng,Zha Kangkang,Sun Yun,Liu Guodong,Yu Chenyan,Hu Yiqiang,Tao Ranyang,Zhou 생화학분자생물학회 2022 Experimental and molecular medicine Vol.54 No.-

        MicroRNAs (miRNAs) broadly regulate normal biological functions of bone and the progression of fracture healing and osteoporosis. Recently, it has been reported that miR-1224-5p in fracture plasma is a potential therapy for osteogenesis. To investigate the roles of miR-1224-5p and the Rap1 signaling pathway in fracture healing and osteoporosis development and progression, we used BMMs, BMSCs, and skull osteoblast precursor cells for in vitro osteogenesis and osteoclastogenesis studies. Osteoblastogenesis and osteoclastogenesis were detected by ALP, ARS, and TRAP staining and bone slice resorption pit assays. The miR-1224-5p target gene was assessed by siRNA-mediated target gene knockdown and luciferase reporter assays. To explore the Rap1 pathway, we performed high-throughput sequencing, western blotting, RT-PCR, chromatin immunoprecipitation assays and immunohistochemical staining. In vivo, bone healing was judged by the cortical femoral defect, cranial bone defect and femoral fracture models. Progression of osteoporosis was evaluated by an ovariectomy model and an aged osteoporosis model. We discovered that the expression of miR-1224-5p was positively correlated with fracture healing progression. Moreover, in vitro, overexpression of miR-1224-5p slowed Rankl-induced osteoclast differentiation and promoted osteoblast differentiation via the Rap1-signaling pathway by targeting ADCY2. In addition, in vivo overexpression of miR-1224-5p significantly promoted fracture healing and ameliorated the progression of osteoporosis caused by estrogen deficiency or aging. Furthermore, knockdown of miRNA-1224-5p inhibited bone regeneration in mice and accelerated the progression of osteoporosis in elderly mice. Taken together, these results identify miR-1224-5p as a key bone osteogenic regulator, which may be a potential therapeutic target for osteoporosis and fracture nonunion.

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