Meta-Analysis of Circulating Endothelial Cells and Circulating Endothelial Progenitor Cells as Prognostic Factors in Lung Cancer

Yu, Min,Men, Hai-Tao,Niu, Zhi-Min,Zhu, Yu-Xi,Tan, Ben-Xu,Li, Long-Hao,Jiang, Juan Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.14

Background: The aim of this study was to analyze the prognostic implications of pretreatment circulating endothelial cells (CECs) and circulating endothelial progenitor cells (CEPCs) for the survival of patients with lung cancer. Materials and Methods: Relevant literature was identified using Medline and EMBASE. Patient clinical characteristics, overall survival (OS) and progression-free survival (PFS) together with CEC and CEPC positive rates before treatment were extracted. STATA 12.0 was used for our analysis and assessment of publication bias. Results: A total of 13 articles (8 for CEC and 5 for CEPC, n=595 and n=244) were pooled for the global meta-analysis. The odds ratio (OR) for OS predicted by pretreatment CECs was 1.641 [0.967, 2.786], while the OR for PFS was 1.168 [0.649, 2.100]. The OR for OS predicted by pretreatment CEPCs was 12.673 [5.274, 30.450], while the OR for PFS was 4.930 [0.931, 26.096]. Subgroup analyses were conducted according to clinical staging. Odds ratio (OR) showed the high level of pretreatment CECs only correlated with the OS of patients with advanced lung cancer (stage III-IV). Conclusions: High counts of CECs seem to be associated only with worse 1-year OS in patients with lung cancer, while high level of pretreatment CEPCs correlate with both worse PFS and OS.

Neutrophil-to-lymphocyte ratio independently predicts advanced pathological staging and poorer survival outcomes in testicular cancer

Yu Guang Tan,Joshua Sia,Hong Hong Huang,Weber Kam On Lau 대한비뇨의학회 2019 Investigative and Clinical Urology Vol.60 No.3

Purpose: An elevated neutrophil-to-lymphocyte ratio (NLR) has been associated with adverse outcomes in various malignancies. However, its role in prognosticating testicular cancer (TC) has not been validated. We aim to study the relationship between NLR and TC. Materials and Methods: We retrospectively reviewed 160 patients with histological proven TC from January 2005 to June 2016. Youden's index was used to analyse NLR and a cut-off point of 3.0 was obtained, with statistical receiver operating characteristics of 0.755. Chi-square test, Kaplan-Meier (log rank test) and logistics regression models were used to predict NLR association with survival outcomes. Results: Median age was 34 years old (range, 17–68 years old). There were 102 pure seminomas and 58 non-seminomatous germ cell tumours. Median follow-up period was 8 years (range, 2.5–17 years). NLR ≥3.0 was independently associated with lymph node involvement (p=0.031; odds ratio [OR], 2.91; 95% confidence interval [CI], 1.67–5.83; p=0.038; OR, 4.12; 95% CI, 1.26–6.51) and metastatic disease (p=0.041; OR, 2.48; 95% CI, 1.22–3.98; p=0.043; OR, 2.21; 95% CI, 1.17–3.65) in both seminomatous and non-seminomatous germ cell tumours, translating to a more advanced disease. Moreover, NLR ≥3.0 also predicts poorer cancer specific survival in these patients. Conclusions: NLR can be an inexpensive haematological marker in predicting advanced TC staging and poorer survival outcome. NLR complements the traditional cancer staging by identifying a group of high risk patients who may benefit from multimodal treatment and closer surveillance to achieve long term survival.

Enantioselective Synthesis of <i>anti</i>–<i>syn</i>-Trihalides and <i>anti</i>–<i>syn</i>–<i>anti</i>-Tetrahalides via Asymmetric β-Elimination

Tan, Yu,Luo, Shilong,Li, Dongmei,Zhang, Nan,Jia, Shiqi,Liu, Yidong,Qin, Wenling,Song, Choong Eui,Yan, Hailong American Chemical Society 2017 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY - Vol.139 No.18

<P>Structural motifs containing contiguous halide bearing stereocenters are common in natural products as well as bioactive molecules. A few successful examples have been reported in the area of asymmetric vicinal dihalogenation of alkenes for accessing dihalogenated products; in this report, an alternative generation method of contiguous halide-bearing stereocenters alpha,beta,gamma,delta relative to carbonyl group in excellent enantioselectivity is proposed by utilizing a Song's oligoEG catalyst-catalyzed asymmetric beta-elimination. According to this methodology, a wide range of anti-syn-trihalides and anti-syn-anti-tetrahalides with high levels of enantioselectivity were synthesized. The synthetic utility of the contiguous halide-bearing stereocenters was demonstrated by several transformations. The results of high-resolution mass spectrometry indicated that the favorable interaction between catalyst and one of the enantiomers of racemic contiguously multihalogenated ketone contributed to the original enantioselectivity of dehydrohalogenation. A deuterium kinetic isotope effect experiment revealed that this beta-elimination reaction proceeds by the E2 mechanism. This strategy opens a new pathway for the asymmetric synthesis of contiguous halide bearing stereocenters of great complexity.</P>

The MALATANG Survey: The <i>L</i>_GAS-<i>L</i>_IR Correlation on Sub-kiloparsec Scale in Six Nearby Star-forming Galaxies as Traced by HCN <i>J</i> = 4 → 3 and HCO⁺<i>J</i> = 4 → 3

Tan, Qing-Hua,Gao, Yu,Zhang, Zhi-Yu,Greve, Thomas R.,Jiang, Xue-Jian,Wilson, Christine D.,Yang, Chen-Tao,Bemis, Ashley,Chung, Aeree,Matsushita, Satoki,Shi, Yong,Ao, Yi-Ping,Brinks, Elias,Currie, Malco American Astronomical Society 2018 The Astrophysical journal Vol.860 No.2

<P>We present HCN J = 4 -> 3 and HCO+ J = 4 -> 3 maps of six nearby star-forming galaxies, NGC 253, NGC 1068, IC 342, M82, M83, and NGC 6946, obtained with the James Clerk Maxwell Telescope as part of the MALATANG survey. All galaxies were mapped in the central 2' x 2' region at 14 '' (FWHM) resolution (corresponding to linear scales of similar to 0.2-1.0 kpc). The L-IR-L'(dense) relation, where the dense gas is traced by the HCN J = 4 -> 3 and the HCO+ J = 4 -> 3 emission, measured in our sample of spatially resolved galaxies is found to follow the linear correlation established globally in galaxies within the scatter. We find that the luminosity ratio, L-IR/L'(dense), shows systematic variations with L-IR within individual spatially resolved galaxies, whereas the galaxy-integrated ratios vary little. A rising trend is also found between L-IR/L'(dense) ratio and the warm-dust temperature gauged by the 70 mu m/100 mu m flux ratio. We find that the luminosity ratios of IR/HCN (4-3) and IR/HCO+ (4-3), which can be taken as a proxy for the star formation efficiency (SFE) in the dense molecular gas (SFEdense), appear to be nearly independent of the dense gas fraction (f(dense)) for our sample of galaxies. The SFE of the total molecular gas (SFEmol) is found to increase substantially with f(dense) when combining our data with those on local (ultra) luminous infrared galaxies and high-z quasars. The mean L'(HCN(4-3))/L'(HCO+(4-3)) line ratio measured for the six targeted galaxies is 0.9 +/- 0.6. No significant correlation is found for the L'(HCN(4-3)) L'(HCO+(4-3)) ratio with the star formation rate as traced by L-IR, nor with the warm-dust temperature, for the different populations of galaxies.</P>

Legit Move

Yu-Hsiu Hung,Hsuan-Lin Lu,Han-Yu Tsai,Shi Wei Tan 한국디자인학회 2016 한국디자인학회 국제초대전도록 Vol.2016 No.12

Effect of Light with Different Wavelengths on Nostoc flagelliforme Cells in Liquid Culture

( Yu Jie Dai ),( Jing Li ),( Shu Mei Wei ),( Nan Chen ),( Yu Peng Xiao ),( Zhi Lei Tan ),( Shi Ru Jia ),( Nan Nan Yuan ),( Ning Tan ),( Yi Jie Song ) 한국미생물 · 생명공학회 2013 Journal of microbiology and biotechnology Vol.23 No.4

The effects of lights with different wavelengths on the growth and the yield of extracellular polysaccharides of Nostoc flagelliforme cells were investigated in a liquid cultivation. N. flagelliforme cells were cultured for 16 days in 500 ml conical flasks containing BG11 culture medium under 27 μmol·m-2·s-1 of light intensity and 25oC on a rotary shaker (140 rpm). The chlorophyll a, phycocyanin, allophycocyanin, and phycoerythrin contents in N. flagelliforme cells under the lights of different wavelengths were also measured. It was found that the cell biomass and the yield of polysaccharide changed with different wavelengths of light. The biomass and the yield of extracellular polysaccharides under the red or violet light were higher than those under other light colors. Chlorophyll a, phycocyanin, and allophycocyanin are the main pigments in N. flagelliforme cells. The results showed that N. flagelliforme, like other cyanobacteria, has the ability of adjusting the contents and relative ratio of its pigments with the light quality. As a conclusion, N. flagelliforme cells favor red and violet lights and perform the complementary chromatic adaptation ability to acclimate to the changes of the light quality in the environment.

TET2 Regulates 5-Hydroxymethylcytosine Signature and CD4+ T-Cell Balance in Allergic Rhinitis

Tan Lu,Fu Lisheng,Zheng Li,Fan Wenjun,Tan Hanyu,Tao Zezhang,Xu Yu 대한천식알레르기학회 2022 Allergy, Asthma & Immunology Research Vol.14 No.2

Purpose: Previous studies have shown the role of ten-eleven translocation 2 (TET2) in CD4+ T cells. However, its function in CD4+ T cells under allergic inflammation is unclear. We aimed to investigate the epigenomic distribution of DNA 5-hydroxymethylcytosine (5hmC) and the role of TET2 in CD4+ T cells of allergic rhinitis (AR). Methods: The hMeDIP-seq was performed to identify sequences with 5hmC deposition in CD4+ T cells of AR patients. Tet2-deficient or wild type mice were stimulated with ovalbumin (OVA) to develop an AR mouse model. The histopathology in nasal mucosae, Th1/Th2/Treg/Th17 cell percentage, concentrations of Th-related cytokines, expression of Tet and differential hydroxymethylated genes (DhMG), and the global deposition of 5hmC in sorted CD4+ T cells were detected. Results: Epigenome-wide 5hmC landscape and DhMG in the CD4+ T cells of AR patients were identified. Tet2 depletion did not led to spontaneous inflammation. However, under the stimulation of allergen, OVA, loss of Tet2 resulted in the exacerbation of allergic inflammation, which was characterized by severer allergic symptoms, more inflammatory cells infiltrating the nasal lamina propria, sharper imbalances between Th1/Th2 and Treg/Th17 cells, and excessive secretion of OVA-specific IgE and Th2-related cytokines. Moreover, altered mRNA production of several DhMG and sharp decrease in 5hmC deposition were also observed in Tet2-deficient OVA-exposed mice. Conclusions: TET2 may regulate DNA 5hmC, DhMG expressions, and CD4+ T cell balance in AR.

프랑스 명품 브랜드의 중국시장 PR활동 및 전략 분석: 에르메스, 루이뷔통, 조르지오 아르마니의 PR활동을 중심으로

담우비 ( Yu Fei Tan ),전형연 ( Hyeong Yeon Jeon ) 한국프랑스문화학회 2016 프랑스문화연구 Vol.32 No.-

L``objectif de cet article, est de comprendre des activites et strategies de relations publiques des marques de luxe representatives comme Hermes, Giorgio Armani, et Louis Vuitton. Les relations publiques designent communement l``ensemble des activites de communication et d``information mises en oeuvre a l``exterieur de l``entreprise pour developper de bonnes relations entre l``entreprise et ses differents publics pour creer un capital de sympathie et renforcer son image. En fait, les relations publiques du luxe reposent sur une diffusion de l’Information fondee sur l``identite de la marque qui se reconnait a ses philosophies et ses ethiques. Nous avons donc essaye d’explorer des strategies des relations publiques des grandes marques de luxe au marche chinois. Notre etude a repose sur l’analyse des activites des marques de luxe pour des consommateurs Chinois comme des evenements, ambassadeurs, relations clients, RSE et sponsorisations. Nous avons eventuellement adapte ce critere d’analyse a trois marques de luxe. Nous souhaiterons y montrer leurs contributions specifiques a la coherence globale pour des clients Chinois a travers leurs activites de RP. Nous avons donc verifie que les trois marques ont deja bati des systemes de RP permettant d’integrer les donnees ethiques et attirantes relatives a la connaissance des clients Chinois. Notre analyse souleve quelques remarques : la premiere remarque repose sur la decouverte des differences de strategies RP pour des clients Chinois parmi trois marques. Mais, nous n’avons pas trouve des grandes differences des activites de RP pour des clients Chinois entre les marques Francaises comme Hermes et Louis Vuitton et la marque Italienne comme Giorgio Armani. Nous nous sommes plutot rendu compte que les strategies de RP de chaque marque a des caracteristiques bien particulieres. Il est vrai que les relations publiques sont une sorte d’outil de differenciation et aussi d’identification. Des activites de RP d``Hermes permettent de montrer la coherence de son identite autour de l’esprit de la marque. Giorgio Armani et Louis Vuitton concentrent leurs efforts sur la promotion de leur notoriete plutot que sur leur signification profonde au marche Chinois. Mais ce qui est en quoi reside probablement l’interet majeur des strategies de RP au marche Chinois, ce sont les originalites et coherences qui se trouvent derriere les activites de RP. Enfin notre recherche est de diriger un chemin de l``avenir en analysant des activites de relations publiques des grandes marques de luxe pour les marques coreennes qui veulent toujours trouver des outils de relations publiques efficaces pour etre reconnaitre leur identite et personnage au marche chinois.

Hydrophobic modification of silica/exfoliated graphite nanoplatelets aerogel and its application as supporting material for form-stable phase change materials

Ni Tan,Yang Feng,Ping Hu,QiLin Ding,Chuan-Huang Lin,Yu-Hao Ning,Hao-Nan Zhou,Linping Yu,Zhong Cao,Ju-Lan Zeng 한국공업화학회 2021 Journal of Industrial and Engineering Chemistry Vol.99 No.-

Hydrophobic modified silica/exfoliated graphite nanoplatelets aerogel (M-SiO2/xGnP) were successfullyprepared via surface modification of silica/xGnP alcogel and followed by ambient pressure drying. Afterwards, form-stable PCMs in which capric–palmitic acids eutectic (CA–PA) was confined in theprepared aerogels were obtained by vacuum infiltration. Characterization of the prepared form-stablePCMs revealed that both the hydrophobic modification and the doping of xGnP could effectively improvethe loading of CA–PA in the aerogel. The unmodified silica aerogel could not adsorb CA–PA, while theloading of CA–PA in the surface modified pure silica aerogel supported form-stable PCM and theunmodified silica/xGnP aerogel supported form-stable PCM were 24.2 wt% and 44.4 wt%, respectively. Besides, the hydrophobic modification and the doping of xGnP showed significant synergistic effect. Theloading of CA–PA in the M-SiO2/xGnP supported form-stable PCM (FPCM/xGnP-20-48) could attain78.9 wt% when the M-SiO2/xGnP was obtained by modifying the alcogel with 20 vol% trimethylchlorosilane for 48 h. The FPCM/xGnP-20-48 not only had high latent heat and good thermal reliability,but also exhibited significantly improved thermal conductivity and alleviated supercooling due to theeffective thermal conductive network formed by xGnP and the promoted heterogeneous nucleation ofCA–PA at interfaces with aerogel.

Precipitation of β-NiAl/Laves Eutectics in a Ru-containing Single Crystal Ni-Based Superalloy

Xipeng Tan,Yu Jun Tan,Tao Jin,Jinlai Liu 대한금속·재료학회 2015 METALS AND MATERIALS International Vol.21 No.2

The precipitation of B2 β-NiAl/C14-Laves eutectics with a volume fraction of ~0.5% in the interdendritic /' eutectic regions of a 3 wt% Ru-containing single crystal Ni-based superalloy has been characterized. It is found that the eutectic reaction Liquid→β+Laves (C14) takes place at the end of solidification process. Transmission electron microscopy image shows that numerous fine “butterfly-like” Laves precipitates with a size of ~30 nm are embedded in the coarse blocky β-NiAl, suggesting a coherent or semi-coherent interface between these two phases. The crystallography relationship of (0001)Laves//(110)β and [1120]Laves//[111]β between Laves and β-NiAl phase was obtained in terms of selected area electron diffraction patterns. Electron probe microanalysis results reveal that 3 wt% Ru addition makes more Al, Ta and other refractory elements segregate to the interdendritic regions, which is believed to be the main reason for this undesirable eutectic reaction. In addition, the formation of these eutectics is found to be strongly affected by solidification conditions.