시각장애학교 교사의 학교도서관 이용 및 활용수업 실태 : A Study on Teachers' Use of the School Library and School Library-Assisted Instruction at School for the Visually Impaired

고유진,정은희 이화여자대학교 특수교육연구소 2015 특수교육 Vol.14 No.3

연구목적: 본 연구는 시각장애학교 학교도서관 이용 및 활용수업 실태를 알아보고자 하였다. 연구방법: 시각장애 중·고등학교 교과 담당 교사 86명을 대상으로 한 조사연구를 실시하였다. 연구결과: 과반수정도가 도서관 활용수업을 진행한 적이 있다고 하였다. 국어교사는 대부분 경험이 있는 반면 다수의 수학교사는 경험이 없었으며, 활용수업을 실시하지 않는 이유로는 과목의 특성을 언급하였다. 도서관 활용수업은 교과수업의 질을 높이기 위해 실시한다고 하였고, 대부분의 교사가 시각장애학생에게 도서관 활용수업이 필요하며 교수학습 면에서도 중요하다고 하였다. 또한 학교도서관 활용수업을 통해 자기주도 학습능력, 정보 활용능력, 수업에 대한 관심과 흥미도가 모두 향상된다고 인식하고 있었다. 도서관 활용수업을 활성화시키기 위해서는 대체자료 및 보조공학기기의 보완, 편의시설이 필요하다고 하였다. 결론: 전담 사서교사의 배치를 통해 체계적인 지원 체계와 전문성을 확보하고 지속적인 연수를 통하여 학교도서관 활용수업에 대한 홍보, 교육과정과의 연계 및 다양한 프로그램과 교수매체의 개발이 필요하다. Purpose: This research examines teachers’ use of school library and their implementation of school library-assisted instruction at middle and high schools for the visually impaired. Method: A questionnaire was distributed to 86 middle and high school teachers for the visually impaired. Results: First, more than a half of the teachers had implemented school library-assisted instruction. While most teachers of Korean had taught library-assisted classes, most math teachers responded that they had not used school libraries because of the nature of the subject matter. Regarding the purpose of school library-assisted instruction, a majority of teachers mentioned the improvement of the quality of teaching and learning. Second, most teachers acknowledged the benefits of library-assisted instruction for visually impaired students and its importance in teaching and learning. The teachers expected that, by utilizing school libraries, they could enhance the visually impaired students’ self-initiated learning ability, information utilization ability, attention and interest in class. Lastly, teachers suggested that alternative materials and assistive technology should be made available for more effective utilization of school libraries. Conclusion: The research indicates that support systems are also necessary, including professional librarians, continual education on school library-assisted instruction, development of connected curriculum, and development of instructional media.

동종 조혈모세포이식 후 발생한 크립토콕쿠스 척추염 1예

고윤호,임동준,이성수,조유경,이동건,최정현,김유진,민창기,김동욱,박정미,김춘추,신완식 대한감염학회 2001 감염 Vol.33 No.4

Skeletal cryptococcosis is an uncommon infection. Cryptococcus is a common cause of meningitis and infects 7∼10% of patients with AIDS. As well as AIDS, the infection may be seen in association with leukemia, lymphoma, Hodgkin's disease, sarcoidosis, tuberculosis and diabetes, also in patients on steroid medication. But there is no case report of skeletal cryptococcosis following allogeneic hematopoietic stem cell transplantation. A 40-year-old woman was admitted to the hospital because of low back pain. She had chronic myelogenous leukemia for 2 years and underwent allogeneic hematopoietic stem cell transplantation 8 months ago. She have been treated with steroid and cyclosporine orally because of chronic graft versus host disease. On examination she was afebrile and had posterior lower lumbar tenderness. But, she had no reduced strength of low extremities. Open biopsy was underwent. Histology demonstrated budding, round-to-oval, refractile yeast-like organisms within debris. The results of a lumbar puncture were unremarkable and cerebrospinal fluid culture failed to grow bacteria and yeast. The patient was treated with amphotericin B (1 gram) and AmBisome□ (2.8 gram) over 6 weeks. Three months after cessation of therapy, the patient was doing well.(Korean J Infect Dis 33:298∼301, 2001)

鐵筋콘크리트 보에서 剪斷鐵筋이 휨耐力에 미치는 影響

고유신,기진호,김병호,은희창,서일교 제주대학교 산업기술연구소 2000 尖端技術硏究所論文集 Vol.11 No.2

Shear reinforcement has an important role to strengthen shear capacity of reinforced concrete beam. Although the flexural design corresponding to design code does not consider the effects of the shear reinforcement, its utilization in flexural region leads to the improved ductility and the enhanced strength by confining concrete. It allows to design the over-reinforcement beam. In this study, we considered the effects of the shear reinforcement on the flexural ductility and strength of reinforced concrete beam according to the spacing of shear reinforcement, steel ratio, and shear span ratio. The flexural capacity depends on the amount of longitudinal bars and the ductility the confinement degree by the shear reinforcement. The flexural analysis varies with the stress-strain relation of confined concrete. The analytical results based on the stress-strain relation presented by Chung almost corresponded to the experimental ones. It was observed that the proper design of shear reinforcement leads to utilize the over-reinforcement concrete beam.

항결핵 치료과정에서 호전되었다가 악화된 뇌 결핵종 1예 보고

이대훈,유진홍,강미자,김홍기,김선화,고동훈,천지성,유원종 대한화학요법학회 1997 대한화학요법학회지 Vol.15 No.3

In spite of nationmide tuberculosis control program, tuberculosis is still prevalent in Korea. Accordingly, tuberculous meningitis also poses one of the main trouble some problems. Recently, We experienced a perplexing case of tuberculous menin-gitis and tubercdoma in a 24-year old female patient. She was admitted to our hospital owing to meningeal irritation sign, aphasia, VI nerve palsy, and ,fever. CSF analysis showed a finding consistent with that of presumptive tuberculous meningitis.. Initial MRI of the brain revealed a large mass(tuhercu1oma) on left parieto-temporal area. Antitubeculous regimen(1soniazid (INH), rifampin(RMP), ethambutol(EMB), pyrazinamide(PZA)} of meningeal dose was given immediately, and her symptoms and signs were dramatically disappeared with a few days after treatment. She was discharged with improved condition and under maintenance treatment of tuberculosis. Follow-up one year after treatment. revealed that the previous lesion was nearly diminished. She showed no symptom at all until she recognized a total blindness of sudden onset on her left eye a t the 18th month of treatment. Brain MRI checked at that time showed multiple masses of tuberculoma scattered over the brain base and one of them invaded left optic nerve. In our opinion, the cause of relapse in this patient might he explained by the selection and ultimate replication of a minor population of resistant strain. Although such relapse is an extremely rare event, we think that we should always pay attention to this possible resistance problem every time we meet patients with tuberculous meningitis.

국내산 과일 및 채소 추출물을 이용한 체중 조절 관련 기능성 식품소재 탐색

김인혜;김종배;조강진;황유진;황경아;고정숙;엄애선 한양대학교 2011 韓國 生活 科學 硏究 Vol.31 No.1

Obesity can be defined as a disorder of lipid metabolism and the control of this process is regulated by enzymes involved in lipid metabolic pathway. Obesity is also characterized increases in the number and size of adipocyte differentiated from fibroblastic pre-adipocytes in adipose tissue. The aim of this study was to screen ethanol extracts of 21 fruits and vegetables cultivated in Republic of Korea for identifying natural sources of lipase inhibitor and to investigate the effects of several extracts resulting in suppression of triglyceride (TG) accumulation in 3T3-L1 cells. Among the tested extracts, Diospyros kaki L. showed the highest contents of total sugar and the content of total phenolic compounds was detected 17 species while there was not detected in Ixeris dentate root and Allium fistulosum C. etc. We were screened 26 extracts of fruits and vegetables for pancreatic lipase inhibitory activity compared with orlistat. The strongest lipase inhibitory activities were shown by extract of Allium sativum L. stem, Allium sativum L. bulb, Apteryx australis, Diospyros kaki L. Malus Pumila, Perilla frutescens and Prunus mume regardless of concentrations treated. Eight extracts including Brassica juncea var. integrilolia had no effect on lipase inhibition. During the differentiation of 3T3-L1 preadipocyte to mature adipocyte, the cells were treated with carrier or 7 extracts(1, 5 and 10 ㎍/ml), which was shown to highest lipase inhibitory effects. We were quantified lipid contents secreted mature adipocytes and stained with Oil Red O. All cells treated with the Apteryx australis and Prunus mume significantly decreased TG contents than the control. These findings suggested that the screened fruit and vegetable could be a promising source as the effective and safe lipase inhibitors for isolating bioactive ingredients and developing functional foods.

Roles of Aluminum Hydroxide and Monophosphoryl Lipid A Adjuvants in Overcoming CD4⁺ T Cell Deficiency To Induce Isotype-Switched IgG Antibody Responses and Protection by T-Dependent Influenza Vaccine

Ko, Eun-Ju,Lee, Young-Tae,Kim, Ki-Hye,Lee, Youri,Jung, Yu-Jin,Kim, Min-Chul,Lee, Yu-Na,Kang, Taeuk,Kang, Sang-Moo American Association of Immunologists 2017 Journal of Immunology Vol. No.

<P>Vaccine adjuvant effects in the CD4-deficient condition largely remain unknown. We investigated the roles of combined monophosphoryl lipid A (MPL) and aluminum hydroxide (Alum) adjuvant (MPL+Alum) in inducing immunity after immunization of CD4 knockout (CD4KO) and wild-type (WT) mice with T-dependent influenza vaccine. MPL+ Alum adjuvant mediated IgG isotypeswitched Abs, IgG-secreting cell responses, and protection in CD4KO mice, which were comparable to those in WT mice. In contrast, Alum adjuvant effects were dependent on CD4(+) T cells. MPL+ Alum adjuvant was effective in recruiting monocytes and neutrophils as well as in protecting macrophages from Alum-mediated cell loss at the injection site in CD4KO mice. MPL+Alum appeared to attenuate MPL-induced inflammatory responses in WT mice, likely improving the safety. Additional studies in CD4-depleted WT mice and MHC class II KO mice suggest that MHC class II+ APCs contribute to providing alternative B cell help in the CD4-deficient condition in the context of MPL+Alum-adjuvanted vaccination.</P>

The Protective Effects of water Extracts of ZoaGumHwan (ZGH) on the Oxidized LDL-induced Monocyte Adhesion to Human Umbilical Vein Endothelial Cells

( Yu Jin Ko ),( Byung Chul Park ),( Jong Suk Lee ),( Su Young Park ),( Heung Mook Shin ),( Bong Kyu Yoo ),( Jung Ae Kim ) 한국응용약물학회 2007 Biomolecules & Therapeutics(구 응용약물학회지) Vol.15 No.3

It is well known that oxidized low-density lipoprotein (oxLDL) is the most characterized humoral factor that plays an important role in the pathogenesis of atherosclerosis. The water extract of the Korean herbal remedy, ZoaGumHwan (ZGH), which is composed of roots of Coptis chinensis Franch and fruits of Evodia officinalis Dode with the ratio of 6 to 1, reduced the in vitro oxidation of low density lipoproteins (LDL). Also, the ZGH extract and berberine, one of the major components of ZGH, significantly prevented oxLDL-induced adhesion of monocytes to human umbilical vein endothelial cells (HUVEC). Furthermore, the ZGH water extract and berberine decreased oxLDL-induced expression of CC chemokine receptor 2 (CCR2), a dominant monocyte chemo-taxis receptor, in U937 human monocytic cells. The protective effects of the ZGH water extract and berberine were similar to those of simvastatin, an effective lipid-lowering drug. The results suggest that Korean herbal remedy, ZGH, seems to have protective effect against oxLDL-induced monocyte chemoattractant protein (MCP)-1/ CCR2-dependent monocyte recruitment onto endothelial cells.

Articles : Life Science ; The Protective Effects of water Extracts of ZoaGumHwan (ZGH) on the Oxidized LDL-induced Monocyte Adhesion to Human Umbilical Vein Endothelial Cells

( Yu Jin Ko ),( Byung Chul Park ),( Jong Suk Lee ),( Su Young Park ),( Heung Mook Shin ),( Bong Kyu Yoo ),( Jung Ae Kim ) 영남대학교 약품개발연구소 2008 영남대학교 약품개발연구소 연구업적집 Vol.18 No.-

Hyaluronic acid derivative-based self-assembled nanoparticles for the treatment of melanoma.

Jin, Yu-Jin,Termsarasab, Ubonvan,Ko, Seung-Hak,Shim, Jae-Seong,Chong, Saeho,Chung, Suk-Jae,Shim, Chang-Koo,Cho, Hyun-Jong,Kim, Dae-Duk Kluwer Academic/Plenum Publishers 2012 Pharmaceutical research Vol.29 No.12

<P>Hyaluronic acid-ceramide (HACE)-based nanoparticles (NPs) were developed for the targeted delivery of doxorubicin (DOX), and their antitumor efficacy for melanoma was evaluated.</P>

Anti-inflammatory Effect and Antioxidative Activities of Ingredients used in Bibimbab

Yu-Jin Ko(고유진),Hui-Gyeong Seol(설희경),Gyeong-Ran Lee(이경란),Gye-Im Jeong(정계임),Chung-Ho Ryu(류충호) 한국생명과학회 2013 생명과학회지 Vol.23 No.2

본 연구에서는 우리나라 전통 음식인 비빔밥의 우수성을 검증하고자 비빔밥에 들어가는 재료인 애호박, 도라지, 숙주, 속대기, 부추, 고사리의 조리 전과 후의 항염증 및 항산화 효과를 조사하였다. 인간유래 비만세포인 HMC-1 (human mast cell)에 70% ethanol로 추출한 조리 전, 후의 다양한 비빔밥 재료의 추출물을 1.0 mg/ml의 농도로 처리한 후, PMA와 A23187로 자극하여 염증반응을 유도하였다. MTT 분석에 의한 세포 생존율 결과, 모든 구에서 82% 이상의 세포 생존율을 보여 조리 전, 후의 비빔밥 재료 추출물에 의한 세포 독성은 나타나지 않았다. HMC-1 비빔밥 재료의 추출물을 0.01, 0.1, 1.0 mg/ml의 농도로 처리한 후, 자극제로 염증반응을 유도하였을 때 그 효과를 TNF-α, IL-6, IL-8의 분비량으로 알아보았다. 전체적으로 cytokine의 분비가 감소하였는데, 특히 1.0mg/ml 농도에서 조리 후의 부추 추출물이 TNF-α, IL-6 분비량을 각각 90%, 93% 저해하였고, 무 추출물은 IL-8 분비량을 85% 저해하여 다양한 비빔밥 재료 중 가장 높은 저해율을 나타냈다. DPPH 분석에 의한 항산화 활성 결과, 조리 전, 후의 부추 추출물에서 각각 67.50%, 73.65%로 재료 중 가장 높았으며 전반적으로, 조리함으로써 항산화 활성이 향상되었다. 결론적으로 조리 전보다 조리 후의 재료에서 세 가지의 cytokine을 유의성 있게 억제하였고, 항산화 활성 또한 높게 나타나 비빔밥의 우수성을 검증하는 기초자료로 활용이 가능하다고 사료된다. Bibimbab (mixed rice) is a traditional Korean one-dish meal. This study was carried out to investigate the anti-inflammatory and antioxidative effects of raw and seasoned ingredients used in Bibimbab (Cucurbita moschata P., Platycodon grandiflorum A., Vigna radiata L., Porphyra yezonensis udea, Allium ampeloprasum L., Pterdium aguilinum, Raphanus sativus). Human mast cells (HMC-1) were pretreated with 70% ethanol extracts of Bibimbab and further cultured for an appropriate time after the addition of phorbol 12-myristate 13-acetate (PMA) and calcium ionophore A23187. Cell viability was determined by an MTT assay. None of the ingredients showed cytotoxic effects at a concentration of 1.0 μg/ml. Anti-inflammatory effects were analyzed at 0.01, 0.1, and 1.0 mg/ml concentrations of the raw, seasoned ingredients of PMA. A23187 stimulated HMC-1. Among the various ingredients, seasoned A. ampeloprasum L. extract showed the highest inhibition of TNF-α and IL-6 secretion (90% and 93%, respectively) at a concentration of 1.0 mg/ml. The R. sativus extract showed the highest inhibition (85%) of IL-8 secretion. DPPH analysis of the antioxidation properties of the ingredients showed that raw and seasoned A. ampeloprasum extracts exhibited the highest DPPH free radical scavenging activity (67.50 and 73.65%, respectively). These results suggest that seasoned ingredients used in Bibimbab have lower anti-inflammatory effects in relation to TNF-α and IL-6 secretion than raw ingredients in PMA- and A23187-treated HMC-1. In addition, the seasoned ingredients showed a tendency to increase antioxidative activity. Therefore, the ingredients used in Bibimbab have potential as anti-inflammatory and antioxidation agents.