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Terahertz Pulse Imaging of Micro-metastatic Lymph Nodes in Early-stage Cervical Cancer Patients
Euna Jung,Meehyun Lim,Youngwoong Do,Soonsung Lee,Hyuck Jae Choi,한해욱,Kyoung-Sik Cho,Kyu-Rae Kim 한국광학회 2011 Current Optics and Photonics Vol.15 No.2
Lymph node metastasis is an important prognostic factor in cervical cancer patients. We report THz imaging for detecting micro-metastatic foci in the lymph nodes of early-stage uterine cervical cancer patients. Five paraffin-embedded metastatic lymph nodes from two cervical cancer patients were imaged using a THz time-domain spectroscopy system in the reflection mode. The size and shape of the tumor regions were compared with those from histopathologic examinations. The metastatic portions of lymph nodes as small as 3 mm were well delineated by THz imaging. The reflected peak amplitudes were lower in metastatic portions than in the normal portions of lymph nodes, and the difference in their peak-to-peak amplitudes was ~5%.
Quantitative Label-free Terahertz Sensing of Transdermal Nicotine Delivered to Human Skin
Gyuseok Lee,Ho Namkung,Youngwoong Do,Soonsung Lee,강현아,Jin-Woo Kim,한해욱 한국광학회 2020 Current Optics and Photonics Vol.4 No.4
We report the terahertz time-domain spectroscopy (THz-TDS) of transdermal drug delivery in human skin. The time evolution of transdermal nicotine delivery in nicotine patches was assessed by detecting the transmission coefficient of sub-picosecond THz pulses and using a semi-analytic model based on the single-layer effective medium approximation. Using commercial nicotine patches (Nicoderm CQ ® , 7 mg/24 h), THz transmission coefficients were measured to quantitatively analyze the cumulative amounts of nicotine released from the patches in the absence of their detailed specifications, including multilayer structures and optical properties at THz frequencies. The results agreed well with measurements by conventional in vitro and in vivo methods, using a diffusion cell with high-performance liquid chromatography and blood sampling respectively. Our study revealed the ability of the THz-TDS method to be an effective alternative to existing methods for noninvasive and label-free assessments of transdermal drug delivery, showing its high promise for biomedical, pharmaceutical, and cosmetic applications.
Terahertz Near-Field Microscope: Analysis and Measurements of Scattering Signals
Kiwon Moon,Euna Jung,Meehyun Lim,Youngwoong Do,Haewook Han IEEE 2011 IEEE transactions on terahertz science and technol Vol.1 No.1
<P>We present the analysis and measurements of scattering signals of a terahertz pulse scattering-type near-field microscope. We used a self-consistent line dipole image method for the quantitative analysis of the THz near-field interaction. The line scan across a gold film demonstrated that the terahertz microscope has a nanoscale resolution of ~80 nm. The measurements of scattering signals on gold and silicon substrates were in good agreement with calculations.</P>
Subsurface Nanoimaging by Broadband Terahertz Pulse Near-Field Microscopy
Moon, Kiwon,Park, Hongkyu,Kim, Jeonghoi,Do, Youngwoong,Lee, Soonsung,Lee, Gyuseok,Kang, Hyeona,Han, Haewook American Chemical Society 2015 NANO LETTERS Vol.15 No.1
<P>Combined with terahertz (THz) time-domain spectroscopy, THz near-field microscopy based on an atomic force microscope is a technique that, while challenging to implement, is invaluable for probing low-energy light-matter interactions of solid-state and biomolecular nanostructures, which are usually embedded in background media. Here, we experimentally demonstrate a broadband THz pulse near-field microscope that provides subsurface nanoimaging of a metallic grating embedded in a dielectric film. The THz near-field microscope can obtain broadband nanoimaging of the subsurface grating with a nearly frequency-independent lateral resolution of 90 nm, corresponding to ∼λ/3300, at 1 THz, while the AFM only provides a flat surface topography.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/nalefd/2015/nalefd.2015.15.issue-1/nl503998v/production/images/medium/nl-2014-03998v_0005.gif'></P>