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Youngkyung. Lee(이용경),Ara. Jung(정아라),Bomi. Gweon(권보미),Dohyung Lim(임도형) 대한기계학회 2021 대한기계학회 춘추학술대회 Vol.2021 No.11
This study was to confirm Human osteoblast-like cell responses according to pore shapes and alterations of the surface characteristic caused additive manufacturing technology based on metal powder. Specimens with pore shape of circle, triangle and square were fabricated by powder bed fusion (PBF) method. The specimens were measured dimensions, areas for compared with designed pore shape models. Also, the curvatures of the specimens were analyzed by micro-CT. Cellular proliferation was measured using cell counting kit-8 (CCK-8). The distribution of molecular markers of cell adhesion were evaluated by immunofluorescence staining. As a result, the curvature characteristic was different depending on the pore shape, in particular, the difference was found in the edges and the angular points. The cell proliferation results showed that the square and triangle pore shape had more cells than the circle pore shape (p < 0.05).
Jaeyeon Jang,Youngkyung Jeon,Sun Young Jeong,Sung Hee Lim,Won Ki Kang,Jeeyun Lee,Seung Tae Kim 대한위암학회 2023 Journal of gastric cancer Vol.23 No.3
Purpose: The optimal tumor mutational burden (TMB) value for predicting treatment response to programmed cell death-1 (PD-1) checkpoint inhibitors in advanced gastric cancer (AGC) remains unclear. We aimed to investigate the optimal TMB cutoff value that could predict the efficacy of PD-1 checkpoint inhibitors in AGC. Materials and Methods: Patients with AGC who received pembrolizumab or nivolumab between October 1, 2020, and July 27, 2021, at Samsung Medical Center in Korea were retrospectively analyzed. The TMB levels were measured using a next-generation sequencing assay. Based on receiver operating characteristic curve analysis, the TMB cutoff value was determined. Results: A total 53 patients were analyzed. The TMB cutoff value for predicting the overall response rate (ORR) to PD-1 checkpoint inhibitors was defined as 13.31 mutations per megabase (mt/Mb) with 56% sensitivity and 95% specificity. Based on this definition, 7 (13.2%) patients were TMB-high (TMB-H). The ORR differed between the TMB-low (TMB-L) and TMB-H (8.7% vs. 71.4%, P=0.001). The progression-free survival and overall survival (OS) for 53 patients were 1.93 (95% confidence interval [CI], 1.600–2.268) and 4.26 months (95% CI, 2.992–5.532). The median OS was longer in the TMB-H (20.8 months; 95% CI, 2.292–39.281) than in the TMB-L (3.31 months; 95% CI, 1.604–5.019; P=0.049). Conclusions: The TMB cutoff value for predicting treatment response in AGC patients who received PD-1 checkpoint inhibitor monotherapy as salvage treatment was 13.31 mt/Mb. When applying the programmed death ligand-1 status to TMB-H, patients who would benefit from PD-1 checkpoint inhibitors can be selected.
Feasibility Test of Flat-Type Faraday Cup for Ultrahigh-Dose-Rate Transmission Proton Beam Therapy
Sang-il Pak,Sungkoo Cho,Seohyeon An,Seonghoon Jeong,Dongho Shin,Youngkyung Lim,Jong Hwi Jeong,Haksoo Kim,Se Byeong Lee Korean Society of Medical Physics 2022 의학물리 Vol.33 No.4
Purpose: Proton therapy has been used for optimal cancer treatment by adapting its Bragg-peak characteristics. Recently, a tissue-sparing effect was introduced in ultrahigh-dose-rate (FLASH) radiation; the high-energy transmission proton beam is considered in proton FLASH therapy. In measuring high-energy/ultrahigh-dose-rate proton beam, Faraday Cup is considered as a dose-rate-independent measurement device, which has been widely studied. In this paper, the feasibility of the simply designed Faraday Cup (Poor Man's Faraday Cup, PMFC) for transmission proton FLASH therapy is investigated. Methods: In general, Faraday cups were used in the measurement of charged particles. The simply designed Faraday Cup and Advanced Markus ion chamber were used for high-energy proton beam measurement in this study. Results: The PMFC shows an acceptable performance, including accuracy in general dosimetric tests. The PMFC has a linear response to the dose and dose rate. The proton fluence was decreased with the increase of depth until the depth was near the proton beam range. Regarding secondary particles backscatter from PMFC, the effect was negligible. Conclusions: In this study, we performed an experiment to investigate the feasibility of PMFC for measuring high-energy proton beams. The PMFC can be used as a beam stopper and secondary monitoring system for transmission proton beam FLASH therapy.
Toward a novel dosimetry system using acrylic disk radiation sensor for proton pencil beam scanning
Cho, Shinhaeng,Lee, Nuri,Song, Sanghyeon,Son, Jaeman,Kim, Haksoo,Jeong, Jong Hwi,Lee, Se Byeong,Lim, Youngkyung,Moon, Sunyoung,Yoon, Myonggeun,Shin, Dongho Published for the American Association of Physicis 2018 Medical physics Vol.45 No.11