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Kim, Hong,Jang, Eungyeong,Kim, So-Young,Choi, Ji-Yoon,Lee, Na-Rae,Kim, Dae-Sung,Lee, Kyung-Tae,Inn, Kyung-Soo,Kim, Bum-Joon,Lee, Jang-Hoon Hindawi 2018 Evidence-based Complementary and Alternative Medic Vol.2018 No.-
<P>Hepatitis B virus (HBV) infectious diseases currently remain incurable due to limitations of conventional antivirals such as incapability of eradicating HBV DNA, prolonged use, drug resistance, and virological relapse. KCT-01, a 30% ethanol extract consisting of<I> Artemisia capillaris</I>,<I> Sanguisorba officinalis</I>, and<I> Curcuma longa</I>, was newly developed. The objective of this study was to investigate pharmacological activities of KCT-01 against HBV using HepG2.2.15 cells and a hydrodynamic injection model. KCT-01 significantly lowered antigen secretion, virion production, and pgRNA synthesis in HepG2.2.15 cells without affecting cell viability. KCT-01 administration also resulted in significant decrease of serum virion production, liver covalently closed circular (ccc) DNA levels, and mRNA synthesis of cytokines in the liver of mice injected with HBV DNA hydrodynamically. Interestingly, coadministration of KCT-01 with entecavir enhanced its<I> in vitro</I> and<I> in vivo</I> antiviral activities. Moreover, safety of KCT-01 was assured up to 5000 mg/kg in rats in both single and repeated-dose preclinical studies. Taken together, our findings demonstrate that KCT-01 is capable of suppressing HBV replication and inflammatory cytokine production in<I> in vitro</I> and<I> in vivo</I> models without showing toxicity, suggesting the potential of using KCT-01 alone or in combination with entecavir as antiviral agent.</P>
오영애,하귀현,박인경,김미향,김미정,김미경,정자림,이명숙,김순동 대구효성가톨릭대학교 식품과학연구소 1992 식품과학지 Vol.4 No.-
This paper showed the summarization of the preservative method of wild vegetables in the house and the precessing method of Japanese pickles. The preservative methods of wild vegetables were explained devided into long, short term, fresh state, heat treatment and drying. Salt, soybean fermented sauce, soybean fermented paste, lees of refined rice wine and residue in the preparation of bean curd were used as the materials of Japanese pickles.
Kim, Young-Inn,Choi, Sung-Nak,Ro, Chul-Un Korean Chemical Society 1994 Bulletin of the Korean Chemical Society Vol.15 No.7
The 2-(dimethylaminomethyl)thiophene (dmamt) complexes with copper(II) chloride and bromide were prepared and characterized by optical, EPR, XPS spectroscopies and magnetic susceptibility measurements. The low-energy absorption band above 850 nm and the relatively small EPR hyperfine coupling constant ($A_{//}{\simeq}$125 G) indicate the pseudotetrahedral site symmetry around copper(II) ion both in Cu(dmamt)$Cl_2$ and Cu(dmamt)$Br_2$ complexes. The higher satellite to main peak intensity of Cu $2P_{3/2}$ core electron binding energy in XPS spectra also supports the pseudotetrahedral geometry around the copper(II) ions having $CuNSX_2$ chromophores. The distortion from square-planar to pseudotetrahedral symmetry is likely to arise from the steric hindrance of the bulky dmamt ligand in the complex. Magnetic susceptibility study shows that these compounds follow Curie-Weiss law in the temperature range of 77-300 K with positive Weiss constant exhibiting the ferromagnetic interaction between copper(II) ions in solid state.
Tunicamycin inhibits LPS-induced inflammation through NF-kB pathway in RAW264.7 macrophage cells
Kim Song-Yi,Hwang Ji-sun,Shin Jin-A,Park Seon-young,Han Inn-Oc 한국당과학회 2011 한국당과학회 학술대회 Vol.2011 No.1
Tunicamycin is an antibiotic that blocks the synthesis of all N-linked glycoproteins. It causes endoplasmic reticulum (ER) stress and induce unfolded protein response (UPR). Recent evidence suggests tunicamycin-inducd ER stress is a possible cause of inflammation. In the present study, we have investigated the role of tunicamycin on lipopolysaccharide (LPS)-induced inflammation in RAW264.7 macrophage. Tunicamycin decreaced inducible nitric oxide synthase (iNOS), Cyclooxygenase-2 (COX-2), and pro-inflammatory cytokine such as interleukin 1 beta (IL-1β) and tumor necrosis factor alpa (TNF-α) expression in response to LPS in RAW264.7 macrophage cells. However, other well-known ER stress inducers, A23187 and Thapsigargin increased LPS-induced COX-2 expression and had no effect on LPS-induced iNOS, TNF-α and IL-1β expression. These results suggest that the inhibitory effect of tuncimaycin on LPS-induced inflammation is independent of its effect on ER stress induction. We further demonstrated that tunicamycin inhibited LPS-induced NF-κB activation. in RAW264.7 macrophage cells.
Kim, Young-Inn,Jeong, Chan-Kyou,Lee, Yong-Min,Choi, Sung-Nak Korean Chemical Society 2002 Bulletin of the Korean Chemical Society Vol.23 No.12
Tetrathiafulvalene(TTF) reacts with $PdCl_2,Pd(NO_3)_2$ and $Pd(hfacac)_2$(hexafluoroacetylacetonate) in ethanol to give $(TTF)_{1.5}PdCl_2$ (1a), $(TTF)_3Pd(NO_3)_2$ (1b) and $(TTF)_4Pd(hfacas)_2$ nd (1c), respectively. $PdCl(TCNQ)_{2.5}{\cdot}CH_3OH(2a)$was obtained from the reaction of $PdCl_2$ with LiTCNQ in methanol via the partial replacement of $Cl^-$ in $PdCl_2$ by $TCNQ^-$anion, whereas the total substitution of the labile $NO_3^-$ in $Pd(NO_3)_2$ yielded pd(TCNQ)·$CH_3OH$ (2b). $Pd(hfacac)_2(TCNQ)_2\cdot3CH_3OH$ (2c) was obtained from $Pd(hfacac)_2$ and LiTCNQ in methanol. The prepared compounds were characterized by spectroscopic (IR, UV, XPS) methods and magnetic (EPR, magnetic susceptibility) studies. The powdered electrical conductivities (${\sigma}_{rt}$) of the prepared compounds at room temperature were about~$10^{-7}S{\cdot}cm^{-1}$. The effective magnetic moments were lass than the spin-only value of one unpaired electron and no EPR signals from Pd metal ions were observed in any of the compounds, indicating that the Pd ions were diamagnetic and the magnetic moments arose from$(TTF)_n$ or $(TCNQ)_n$ moieties. The experimental evidences revealed that the charge transfer had occurred form $(TTF)_n$ moiety to the central Pd metal ion in 1a, 1b and 1c. Thus the TTF donors were ions in 2a and 2b were diamagnetic Pd(II) oxidation state. In contrast, the Pd metal ion was oxidized to Pd(IV) state in 2c as a result of an addition of $TCNQ^-$anion to $Pd(hfacac)_2$ in methanol. The oxidation states of the Pd metal ions were confirmed using the x-ray photoelectron spectroscopy.
The Role of Sodium-taurocholate Co-transporting Polypeptide as a Receptor during HBV Infection
Kim, So-Young,Jang, Eungyeong,Inn, Kyung-Soo 대한미생물학회 2016 Journal of Bacteriology and Virology Vol.46 No.4
According to World Health Organization, more than 200 million people suffer with chronic hepatitis caused by Hepatitis B virus (HBV) infection worldwide. Chronic hepatitis B causes various complications including liver cirrhosis and hepatocellular carcinoma and approximately 0.5~4.2 million deaths occur annually due to HBV infection. Current therapies such as antivirals and vaccine are often hampered by drug intolerance, side effects, and long-time medication, therefore, the development of powerful anti-HBV drugs is demanded. Recently, sodium taurocholate co-transporting polypeptide (NTCP) receptor was revealed to play a pivotal role in HBV entry into hepatocytes. Cell lines transfected with NTCP receptor enables to analyze HBV life cycle by inducing HBV infection stably, but in vivo models still have some limitations such as high costs, restrictive differentiation, and unveiled cofactors related to human NTCP. Therefore, it requires well-established in vivo models to develop and evaluate novel therapeutic agents targeting NTCP receptor, and viral entry inhibitors that inhibit the early step of viral infection are potent sufficient to substitute for existing antivirals.