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      • 單調增加荷重을 받는 平面 트러스의 複合 非線型 擧動에 關한 硏究

        權寧煥,金和中,金明璇,魯德煥 경북대학교 산업기술연구소 1990 産業技術硏究誌 Vol.18 No.-

        The object of this study is that develop computer program as being derive simple formula considering complex (material and geometric) nonlinear, and select the most useful truss in efficiency with the analysis Howe truss, Fink truss, Pratt truss and Warren truss. The complex nonlinear behavior is considered in this paper, so is acquired following results. 1. We developed program that could analyze complex nonlinear of plane truss. 2. In view of the results analyzied the numerical analysis example of plane truss, When Howe truss, Fink truss, Pratt truss, and Warren truss are equal to weight and span, and the same load is loaded. Among the trusses of same weight, Warren truss is the most useful in efficiency. And When height of warren truss is changed, the lower height of truss, the more useful in efficiency

      • 불소화계면활성제 함유 DPPC/Cholesterol 및 DPPG/Cholesterol 베지클의 BSA(bovine serum albumin)친화성 연구

        권경옥,김명자,김현영 숙명여자대학교 자연과학연구소 1998 자연과학논문집 Vol.- No.9

        본 연구에서는 항원(antigen). 항체(antibody) 등을 삽입시켜 자극반응성 베지클을 제조의 예비실험으로 대표적인 생체 단백질 BSA(bovine serum albumin)와 베지클의 친화도에 관해 알아보았다. DPPC(dipalmitoylphosphatidylcholine)/Chol, DPPG(dipalmitoylphos-Phatidylglycerol)/Chol,DPPC/Chol/FFS(ammonium pentadeca-fluorooctyrate)/FS(sodium bis(1H,1H,2H,2H-heptadecafluorodecyl)-2-sulfosuccinate), DPPG/Chol/ FFS/FS의 4종의 베지클을 제조하고, 제조된 4종의 베지클에 대해 column chromatography 법에 의해 BSA와의 흡착 여부를 확인했다. 실험 결과, 각 계의 베지클 입자크기는 BSA의 흡착으로 인해 감소하는 것으로 나타났고, 감소하는 정도는 DPPC/Chol와 DPPG/Chol에서 큰 것으로 나타났다. 반면, 제조된 계의 제타전위(ξ-Potential)값에는 거의 변화가 없었다. BSA와의 결합친화력의 비교에서는 DPPC/Chol. DPPG/Chol. DPPC/Chol/FFS/FS. DPPG/Chol/FFS/FS 순으로 낮아진다는 결과를 얻었다. 이들 실험결과에 바탕하여, 위의 4종의 베지클과 BSA와의 결합친화력에 대해 베지클의 표면전하와 베지클 막의 밀집성(compactness)이 영향을 미친다는 결론을 얻었다. The purpose of this study is to prepare a functional vesicle for the possible use as a biosensor. In this work, we have performed a preliminary experiment for biosensor, Four different systems of vesicle have been prepared with the composition of DPPC(dipalmitoylphosphatidylcholine)/Chol, DPPG (dipalmitoylphos-phatidylglycerol)/Chol, DPPC/Chol/FFS(ammonium pentadecafluoro-octyrate)/FS(sodium bis(1H,1H,2H,2H-heptadecafluorodecyl)-2-sulfosuccinate) and DPPG/Chol/FFS/FS. By use of column chromatography, it was found that BSA has been adsorbed onto the vesicle structure. The size of vesicle was found to decrease as adsorption occurs between the two species and the extent was greater in the systems of DPPC/Chol and DPPG/Chol. However, the δ-potential of the system remained essentially unchanged. The affinity of vesicle to BSA was found to decrease in the order of DPPC/Chol, DPPG/Chol, DPPC/Chol/FFS/FS and DPPG/Chol/FFS/FS. Based on these findings, it may be concluded that the affinity of vesicles onto BSA was affected by the surface charge and the compactness of vesicle.

      • SCOPUSSCIEKCI등재
      • 흉통의 양상에 따라 분류한 불안정형 협심증 환자의 임상적 소견의 비교

        김명수,김성구,정호석,온영근,신원용,김철현,최태명,현민수,권영주 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.1

        Background and aims : The clinical syndrome unstable angina pectoris that encompasses a variety of symptoms and clincal presentations of transient episode of myocardial ischemia, was devided to several subgroups. Also, it has variable pathophysiologic factors to cause myocardial ischemia. According to clincal presentation, coronary angiographic finding and prognostic factor, the result of unstable angina pectoris is variable. In fact, there were a few data reported on the prognosis of wide spectrum of patients with unstable angina. However, the precise risk of subgroups according to classitication has not been established because it was difficult to compare between studies. We classified unstable angina pectoris by clinical nature of chest pain, and performed to establish and compare the clinical presentations, coronary angiographic findings, treatement and prognosis of patients with unstable angina within subgroups of classification. Methods : Retrospenctive data for 164 unstable angina pectoris patients admitted to the Internal Cardiology Division of Soon Chun Hyang University Hospital from May 1996 to July 1999 was analyzed. The patients were classified into one of the following categories: Class I, new onset of severe angina; Class II, acceleration of previous chronic stable angina; Class III, angina at rest. Clinical presentations, echocardiographic findings, coronary angiographic findings, treatment and prognosis were compared. Results : From the total 164 patients, the subjects of classes were as follows : Class I, 46 cases (28.1%); Class II, 74 cases (45.1%); Class III, 44 cases (26.8%). In view of age distribution, the 7th decade had the highest incidence, and then, 6th, 8th decades were followed. There was no baseline differences among the 3 classes with respect to gender, number of risk factors. Significantly, class II showed more severe findings in abnormal Q wave 15 cases (20.8%), total occclusive lesion 10 cases (20.8%) and three vessel coronary disease 11 cases (22.9%) than other classes. The change of ST segment was significantly apparent (p<0.02) among class I 28 cases (60.8%), class III 26 cases (59.0%), comparing with class II 30 cases (40.5%). Class III had the higher incidence of one vessel coronary artery disease than class I and III. The heparin treatment was performed in 99 cases (60.1%). The incidence of nonfatal myocardial infarction was much more in class I and III, each 4 cases (8.7%, 9.8%) than in class II 1 cases (1.4%). In-Hospital death was occurred in class I and II, each 1 case. Conclusion : The patients with the acclerated angina from chronic stable angina had more severe coronary artery disease than other classes, but they had better in-hospital prognosis.

      • KCI등재
      • SCOPUSKCI등재

        무갑상선 쥐에서 중식성 반흔의 새로운 실험모델

        김영진,이백권,장도명,조길환,임풍 大韓成形外科學會 1999 Archives of Plastic Surgery Vol.26 No.4

        Proliferative scarring in the form of keloids and hypertrophic scars continues to be a clinical problem for some patients. The lack of an animal model for such scarring has been an obstacle to studying the biology and effective therapy of these entities. Consequently we created an accurate reproductive animal model to systematically study them. Human proliferative scars were explanted into flaps based on isolated vascular pedicles in congenitally rats. We compared the procollagen type Ⅲ peptide levels of proliferative scar tissue before and after explanting. The procollagen type Ⅲ peptide levels of explanted proliferative scar tissue remained increased as before explanting. Histological analysis of the explanted proliferative scar tissue revealed that all explants retained their original histotypic character even after 1 year. We could also retain the volume of implanted proliferative scar for 1 year and studied in vitro cellular proliferation. Fibroblast cultures from explanted scars demonstrated less aggressive growth characteristic than those from original surgical specimens. The advantages of this animal model are as follows: 1. The explants retain their histotypical character for a long period. 2. Placement of the explants outside the dorsum of a nude rat makes serial observation and measurement easier. 3. Agents under test can be injected into the explants through a catheter inserted into a single pedicle of island flap without the possibility of spreading systematically.

      • 한국인 심부전증 환자 심근에서의 인형 거대 세포 바이러스 감염

        이명용,이무용,김영권,한성식,최성준,김효수,이영우,서정돈 단국대학교 1998 論文集 Vol.33 No.-

        Objectives: In order to evaluated the prevalence and the site of infection of cytomegalovirus in terminally failing heart, cytomegaloviral DNA was detected in the explanted hearts of transplantation recipients. Methods: DNA extractions were performed from explanted failing hearts(N=22) and normal hearts(N=5) and polymerase cain reactions(PCRs) were done for detection of late gene sequence coding pp150 glycoprotein. The products were confirmed by electrophoresis on the 1% agarose gel. n order to improve the detectability of cytomegaloviral genome, nested PCRs were executed with the primers designed for the original 607 bp products. In situ PCRs also were done with the samples which were confirmed as positive for CMV viral genome by nested PCRs. Results: All patients had IgG anti-cytomegalovirus antibody and did not have IgM anti-cytomegalovirus antibody. Cytomegaloviral genomes in myocardium were detected by polymerase chain reaction. The 607bp products by PCRs were found in both explanted failing heart(3 cases/22. 13.5%) and normal hearts( 1 case/5, 20.0%). In nested PCRs, 186bp products were found in both failing hearts(LV 4/22, LA 3/2, RV 4/22, RA 0/17) and normal hearts(LV 2/5, LA 1/4, RV 2/5, RA 2/5). These was no significant change in positivity of cytomegaloviral DNA genome between failing and normal hearts. Total positivity of cytomegaloviral genome in explanted hearts was 44.4% according to the nested PCR results. The positivity of cytomegaloviral DNA by n situ PCR was 33.3%(4/12), and the site of positive reaction was the nuclei of the myocardial cells. Conclusion: Cytomegalovirus was rarely observed in explanted hearts of terminal heart failure and nested PCR could enhance the sensitivity of cytomegaloviral genome detection. The result of the in situ PCR showed the site of the cytomegaloviral infection was nuclei of the myocardial cells. Cytomegalovirus, however, might have no direct causal relationship in the development of terminal heart failure.

      • 운동분류에 따른 체구성 성분 및 BMI의 비교

        최명화,권영우,김진해,민경선,민진아 한국스포츠리서치 2001 한국 스포츠 리서치 Vol.12 No.4

        The purpose of the present was to investigate the body composition and BMI in different sports groups with classification of sports. 121 male collegiate athletes were recruited from varsity team of golf(n=10), field hokey(n=18), tennis(n=8), judo(n=17), weight lifting(n=27), boxing(n=19) and bicycle(n=22). Sports event can be classified as low static/low dynamic such as golf(LSLD), low static/high dynamic such as hokey and tennis(LSHD), high static/low dynamic such as judo and weight lifting(HSLD), high static/high dynamic(HSHD) such as boxing and bicycle. With classification of sports events, percentage of body fat was significantly higher with HSLD group compared to HSHD group, but no measurable difference was LSLD and LSHD groups. LBM was significantly greater with HSLD group compared to LSHD and HSHD groups. Furthermore BMI of the HSLD group was higher than the other groups(p<.05). In conclusion, high static/low dynamic group were greater in %fat, LBM, BMI than other groups. The differences observed between different sports groups and classification of sports are related to metabolic and dynamic properties in different sports events.

      • 특발성 결절성 지방층염

        고명권,조문균,정현,김영근 순천향대학교 1994 논문집 Vol.17 No.2

        Idiopathic nodular panniculitis is an inflammatory disease of subcutaneous fat tissue which is clinically characterized by recurrent crops of nodular panniculitis. Some cases are accompanied by systemic features such as fever, malaise, abdominal pain and arthritis. We report a case of idiopathic nodular panniculitis in 36 year-old woman, who had erythematous subcutaneous nodules on the extremities, trunk and face accompanied by various general symptoms such as fever, malaise, abdominal pain and weight loss.

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