18–30세 사이에 발생하는 뇌경색의 특징, 다기관 레지스트리 연구

장윤경,송태진,김용재,허지회,이경열,김영은,장민욱,조수진,강석윤 이화여자대학교 의과학연구소 2017 EMJ (Ewha medical journal) Vol.40 No.3

Objectives: Although there have been several reports that described characteristics for young age stroke, information regarding very young age (18–30 years old) has been limited. We aimed to analyze demographic factors, stroke subtype, and 3-month outcome in acute ischemic stroke patient who have relatively very young age in multicenter stroke registry. Methods: We evaluated all 122 (7.1%) consecutive acute ischemic stroke (within 7 days after symptom onset) patients aged 18 to 30 from 17,144 patients who registered in multicenter prospective stroke registry, 1997 to 2012. Etiology was classified by Trial of Org 10172 in Acute Stroke Treatment criteria. Stroke severity was defined as National Institutes of Health Stroke Scale (NIHSS) and stroke outcome was defined by modified Rankin scale (mRS) at 3 months after index stroke. Results: The mean age of all included patients was 25.1±3.7 years and 76 patients (62.2%) were male. The median NIHSS at admission was 4. Considering stroke subtype, 37 patients (30.3%) had stroke of other determined etiology (SOD), 37 (30.3%) had undetermined negative evaluation (UN) and 31 (25.4%) had cardioembolism (CE) were frequently noted. After adjusting age, sex and variables which had P<0.1 in univariable analysis (NIHSS and stroke subtype), CE stroke subtype (odds ratio, 4.68; 95% confidence interval, 1.42–15.48; P=0.011) were significantly associated with poor functional outcome (mRS≥3). Conclusion: In very young age ischemic stroke patients, SOD and UN stroke subtype were most common and CE stroke subtype was independently associated with poor discharge outcome.

생약추출물 유도형 Nitric Oxide Synthase 저해활성 검색

류재하,이소영,박재현,이화진,장세란,은진희,김남이,정연수,장미경,최영은,이숙현,손행자,안한나,고혜진 숙명여자대학교 약학연구소 2001 약학논문집-숙명여자대학교 Vol.17 No.-

Nitric Oxide (NO), derived from L-arginine, is produced by two types (constitutive and inducible) of nitric oxide synthase (NOS: cNOS and iNOS). The NO produced in large amounts by the iNOS is known to be responsible for the vasodilation and hypotension observed in septic shock and inflammation. The inhibitors of iNOS, thus, may be useful candidate for the treatment of inflammatory diseases accompanied by the overproduction of NO. We prepared alcoholic extracts of herbal drugs which have been used for the treatment of inflammation in oriental medicine. We have screened the inhibitory activity of NO production in lipopolysaccharide (LPS)-activated macrophages after the treatment of these extracts. Among the 81 kinds of extracts of herbal drugs, 34 extracts showed potent inhibitory activity of NO production above 50% at the concentration of 50 (μg/ml. The inhibitory activities of NO production were also evaluated for several solvent fractions at three different concentrations. Especially, hexane soluble fractions of Agrimonia pilosa, Hydrangea serrata, Machilus thunbergii, Prunella vulgaris, Saussurea lappa, Tussilago farfara, and ethyl acetate soluble fractions of Angelica gigas, Ostericum koreanum, Torilis japonica, Perilla frutescence showed moderate activity at 10 and/ or 25 (μg/ml. These fractions are promising candidates for the study of the activity-guided chromatographic purification of active compounds.

영양표시정착화사업(Ⅱ) : 식품참고량설정에 관한 연구 Study on the Establishement of the Reference Amount in Foods

김대병,장영미,김인복,이혜영,장재희,김보영,이정구,김창민,정해랑 식품의약품안전청 2000 식품의약품안전청 연보 Vol.4 No.-

본 연구는 영양표시에서 1회분량 및 영양소함량표시의 기준으로 사용되는 "식픔창고량"에 관한 연구를 수행하므로써 합리적이고 일관성있는 영양표시기준 개선을 위한 기초자료로 활용코자 하였다. 이를 위하여 미국 및 캐나다를 중심으로 제외국의 현황 및 식품참고량 설정방법을 조사 ·연구 하으며 제도도입 및 개선 방안을 강구하였파. 또한, 시판 제품의 영양료시현황 및 음료류 둥의 포장단위 등을 피악하여 식품참고량설정을 위한 기초자료로 활용코자 하였다. 앞으로 국민건강 ·영양조사자료의 체계적인 통계분석, 가공식품의 섭취량조사 등을 통하여 우리나라 국민의 1인 1회 섭취량자료의 축적이 선행되어야 할 것이다. The purpose of this ?roject is to study on the reference amounts customarily consumed per eating occasion to improve the nutrition labelling standards. We Performed to study on the methodology to establish the reference amounts on the basis of the review on the advanced counITy's status. And we investigated the packaged unit ofprocessed foods. Further study is needed to establlsh the customarily consumed amount per eating occasionthrough the statistical analysis of nationwide food consumption data. Our results will be helpful information to improve nutrition labelling system in Korea.

산업자재용 폴리에스터 섬유의 강도 향상에 관한 연구

박영신,남영식,정상영,최재호,장기혁,박원호,Park, Young-Shin,Nam, Young-Sik,Jung, Sang-Young,Choi, Jae-Ho,Jang, Ki-Hyuk,Park, Won-Ho 한국섬유공학회 2012 한국섬유공학회지 Vol.49 No.1

In this work, effects of total draw ratio change on the mechanical properties of polyester fibers were studied. The process parameter was a total draw ratio and the draw ratios that were used ranged from 6.6 to 7.0. Tensile properties are determined from the tensile tester, and crystallite parameters from the density measurement and X-ray diffraction were discussed with the different total draw ratios. The tenacity, young's modulus and crystallinity were increased to 10.6 g/d, 123.2 g/d and 42.1%, respectively, with increase in the total draw ratio. The relations between total draw ratio and mechanical properties of high tenacity polyester fiber were discussed.

고강도 콘크리트 기둥부재의 횡보강효과 산정에 관한 연구

장일영,박훈규,송재호 金烏工科大學校 1998 論文集 Vol.19 No.-

High-strength concrete represents a rather recent development in concrete materials technology. In recent years, a considerable amount of research work has been carried out on the mechanical and structural properties of high-strength concrete. However, there has been little research on the behavior of hight-strength concrete columns laterally reinforced with square ties and subjected to compressive loading. With the addition of transverse reinforcement which lead to triaxial compressive state, ductility behavior of high-strength column member shall be increased. In this study, rational quality and quantity evaluations were made to investigate the ultimate strength and strain ductility by confinement effect of tie reinforced hight-strength concrete columns subject to uniaxial loads. Concrete failure theory at the triaxial compressive state and statistical results based on conventional experimental data were applied for this propose. Up to 185 columns, tested under monotonically increasing concentric loading, were evaluated in terms of strength and strain ductility. Analytical results show that confinement stress, maximum compressive strength, and increase of strain equations were developed with the consideration of concrete strength, yield strength, spacing, volumetric ratio, and configurations of tie reinforcement.

전단-스팬비가 작은 고강도 철근콘크리트 보의 진단성능

장일영,최광진,송재호 金烏工科大學校 1993 論文集 Vol.14 No.-

This paper is an experimental study on shear capacity of the high strength R/C beams with a shear span-depth ratio between 1.5 and 2.5 A total of 15 beams was tested to determine diagonal cracking and ultimate shear strength. The major variable are shear span-depth ratio(a/d=1.5, 2.0, 2.5), vertical shear reinforcement ratio?? and concrete compressive strength??. Test results indicate that ACI 318-89 Eq(11-31) generally underestimates shear strength carried by vertical shear reinforcements, and the mode of failure may change from shear tension to shear compression for the beams having higher Vs than 75%, thus the effectiveness of r fy on ultimate shear strength(Vu) decreased.

Wigner 분포 함수를 이용한 위상지연 함수에 대한 연구

장남영,은재정,강호정,최평석 國立 昌原大學校 産業技術硏究所 2000 産技硏論文集 Vol.14 No.-

작은 초점 심도를 갖는 원형 대칭 광시스템에 대하여 Wigner 분포 함수(WDF)를 적용해 얻은 위상 지연 함수와 초점 심도와의 관계를 설명한다. 일반적인 광시스템의 이차원의 원형 개구는 잘알려진 변환식에 의해 일차원 동공 함수로 변환되고 변환된 일차원 동공 함수는 다시 Wigner 함수로 표현된다. 일반적으로 일차원 함수를 Wigner 함수로 변환시키면 2차원 함수가 된다. 초점 심도와 위상 지연 함수와의 관계는 2차원 위상 공간(χ, ζ)으로 표현되는 Wigner 함수를 χ축으로 α만큼 기울이므로써 얻을 수 있다. 여기서 초점 거리 f를 1220mm, 구경이 12.5mm, 사용된 광파장 λ가 633nm일 때 α값에 따른 초점 심도의 변화를 수치해석 한다.

위의 유암종과 선종의 병발 1례

장재식,강혁주,이중현,서영범,윤병구,김용섭,이구,서정일,양창헌,이창우,김정란,윤환중 東國大學校醫學硏究所 2000 東國醫學 Vol.7 No.-

유암종은 전신에 퍼져 잇는 장크롬친화성 세포에서 기원하는데 위의 유암종은 비교적 드문 질환으로 모든 유암종의 1.9~2.2%에 해당하며 위에 발생하는 종양의 1% 미만에서 보고되고 있다. 유암종은 일반적으로 증상이 비특이적이고 면역조직화학검사에 의해서 진단되기 때문에 과거에는 드물게 발견되었으나 최근 내시경 기기 및 술기의 발전과 검사 빈도의 증가 및 면역조직화학검사의 발달로 진단율이 증가 추세에 있으며, 드물지만 유암종에서 선암과 공존하는 예들이 보고되고 있다. 저자들은 심와부 동통을 주소로 내원한 70세 남자 환자의 상부위장관내시경 검사에서 위체상부의 대만곡에서 0.4×0.4 cm 크기의 중간 함몰을 가진 Yamada 1형의 용종과 함께 전정부의 전벽에서 0.8×0.5 cm 크기의 융기된 점막 소견을 보여 조직학적으로 각각 위유암종 및 위선종임을 확진한 후 내시경적 용종 절제술로 치료한 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Carcinoid tumors are arisen from enterochromaffin cells, which are scattered throughout the body. These tumors are composed of variable numbers of cells that contain endocrine granules in their cytoplasm, which can be identified by immunohistochemistry and electron microscopy. Gastric carcinoid tumors are relatively rare tumor, the reported incidence being 1.9~2.2% of all carcinoid tumors and less than 1% of all gastric tumors. Sometimes, composite carcinoid tumors and adenocarcinoma is reported. We experienced a case of the coincidence of carcinoid tumor and adenoma at the other site of the stomach in a 70 year old male patient. Gastrofiberscope showed 0.4×0.4 cm sized Yamada type I polyp with central depression on the greater curvature of the proximal body and 0.8×0.5 cm sized focal slightly elevated mucosa on the anterior wall of the antrum. The endoscopic biopsy specimens revealed carcinoid tumor and tubular adenoma with moderate atypism, respectively. The carcinoid tumor and adenoma were removed by endoscopic polypectomy. According to the follow-up gastrofiberoscopy after 7 month later, both lesions were nearly normal mucosa except whitish atrophic change after polypectomy.

LaCrO₃후막 소자의 가스에 대한 감지 특성

장재영,박기철,신정호,김정규 慶尙大學校生産技術硏究所 1998 生産技術硏究所論文集 Vol.14 No.-

LaCrOa₃ thick-film sensors were fabricated on an alumina substrate by the screen printing method. The sensitivities for gases were investigated by varying the heat treatment temperatures of the films. The sensitivities of LaCrO₃ thick-film for ?? and NH₃ gases were better than those for CO and NO gases. The best condition of heat treatment was 450℃ and the optimal operating temperature of LaCrO₃ thick-film for the highest sensitivity was 400℃. Sensitivities of LaCrO₃ thick-film about at 3000ppm for ?? and NH₃gases were 85% and 95%, respectively.

천연염료를 이용한 무늬염법

장영호,이재범 한국공예학회 1999 조형디자인연구 Vol.2 No.2

The natural dye substance largely consists of plant, animal and minerals materials, which we can easily and naturally be obtained all around us. It has been widely used all around the world for numerous years. The natural dye substance appears to have a lot of benefits that enable the dyed material to show natural merits which in turn enables the dyed materials to exhibit their natural colors. It may have a little bit of a damaging effect on the human body itself. , in comparison to the synthetic substances. It also causes hardly any environmental pollution because of the natural chemicals and costs much less to dispose of. on the other hand it also has disadvantages, that is it's difficult to get various kinds of patterns on the cloth. The dyeing process is done by full saturation, which is only available for commercial use because of the low ratio of dyeing success. The product of the dye substance is limited, the reliability of the dyed material is low, and it is easy to make dark and light colors. For the reasons mentioned above, the use of the natural dye is decreasing except for special uses. Nowadays it is very difficult to come across this method because of he appearance of synthetic dye substances. The dyeing process by saturation into the natural dye substance is done by putting the material, ready for dyeing, into the dye-water once or several times repeatedly. It also has several problems, which include, the complexity of the dyeing process, the low reliability of the dyeing substance and the dependence on manual work done by observing with the naked eye. Eventually, these problems caused the slow down of industrialization. Furthermore, the mixed use of dye substances and it's catalyst caused to develop the natural dye substance and to increase the dye's adhesiveness to the material. Those are the disadvantages of it's use. This is the method to study silk screen printing by using natural dye substance to make a specific patterns on the clothing using various methods. The silk screen printing needs to have the material dyed by the saturation method. Then the silk screen is printed by subtracting the colors to make another shade of color without using any additional dye substance. It only uses the natural dye substance mixture and it's catalyst. It will help to print specific patterns on the material. Therefore it's effects are available for using in various kinds of silk screen printing and to make different kinds of patterns equal to the natural dye substance method, which is both saturating and then printing.